Sepsis and Organ Dysfunction : The Challenge Continues

The Challenge Continues

By: A.E. Baue (Editor), G. Berlot (Editor), A. Gullo (Editor)

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Paperback | 1 December 1999

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An experienced physician knows how to recognize a patient suffering from sepsis, but cannot accurately determine whether the patient will survive. Cardinal elements of the treatment for sepsis include specific antibiotic and vasoactive drugs, enteral and parenteral nutrition, artificial respiration, and optimization of the oxygen transport to tissues. Nonetheless, with a certain frequency, these techniques are insufficient to ensure the recovery of a critically ill patient, especially when it is necessary to overcome functional alterations subsequent to organ and vital-system overload. The key elements in the progression of the sepsis-MODS syndrome are tied to numerous factors. These include: the severity and location of the lesion; the patient's age; the remaining functional reserve; the presence of mediatory which may be stimulatory, inhibitory or both.

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Non-Fiction Medicine Nursing & Ancillary Services Nursing Nursing Specialities Intensive Care Nursing Clinical & Internal Medicine Diseases & Disorders Infectious & Contagious Diseases Other Branches of Medicine Accident & Emergency Medicine Intensive Care Medicine

Surgery Anaesthetics Pathology

Introduction	p. 11
Sepsis and Organ Dysfunction. The Challenge Continues	p. 17
Oxygen Transport in Sepsis
Biochemical Regulation of the Microcirculation	p. 37
Oxygen Supply and Consumption in Tissues	p. 43
Ischaemia-Reperfusion in Sepsis	p. 49
Mechanism of Oxygen Extraction Defect in Septic Shock	p. 57
Organ Dysfunction and Biohumoral Mismatch in Sepsis
Gut Perfusion in Sepsis and Shock	p. 67
Pathophysiology of Encephalopathy	p. 77
Lung Dysfunction in the Early Phase of Sepsis	p. 85
The Kidney in Sepsis	p. 91
Pathophysiology of Liver Dysfunction in Sepsis	p. 103
Inflammatory Cells in Septic Shock	p. 107
Sepsis Trial
Revised Terminology on Sepsis	p. 115
The Epidemiology and Outcome of Patients with Sepsis: Clear as Mud	p. 123
Are there Useful New Markers of Sepsis?	p. 137
A Paradigm Shift: The Bidirectional Effect of Inflammation on Bacterial Growth	p. 145
Is the Dosing and Timing of the Intervention Adequate?	p. 155
Clinical Trials of Mediator-Targeted Therapy in Sepsis	p. 161
Index	p. 175
Table of Contents provided by Blackwell. All Rights Reserved.

Sepsis and Organ Dysfunction : The Challenge Continues

The Challenge Continues

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