Brain Norepinephrine

Neurobiology and Therapeutics

By: Alan Frazer (Editor), Gregory A. Ordway (Editor), Michael A. Schwartz (Editor)

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Hardcover | 15 February 2007

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662 Pages

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Norepinephrine is a chemical neurotransmitter. Drugs that directly manipulate central nervous system (CNS) norepinephrine are being developed targeting noradrenergic neurons to deliver therapeutic effects. Noradrenergic drugs have been proven effective for depression and ADHD, and new disease indications are being identified. Recent discoveries about norepinephrine's contribution to health, disease, and therapy make this synthesis of evidence, practice and research very timely. A team of experts provides the reader with a thorough understanding of the anatomy, physiology, molecular biology, pharmacology, and therapeutics of norepinephrine in the brain, including an extensive review of the role of norepinephrine in brain diseases. The book is divided into four sections: the basic biology of norepinephrine; the role that norepinephrine plays in behavior; evidence of norepinephrine's role in CNS diseases, and the pharmacology and therapeutics of noradrenergic drugs in the treatment of psychiatric and neurological disorders.

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Non-Fiction Science Biology, Life Sciences Life Sciences in General Neurosciences Medicine Other Branches of Medicine Pharmacology

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Published: 13th September 2012

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List of contributors	p. viii
Acknowledgements	p. xii
Introduction: revision of an old transmitter	p. 1
The neurobiology of norepinephrine
Neuroanatomical and chemical organization of the locus coeruleus	p. 9
Interactions of norepinephrine with other neurotransmitter systems: anatomical basis and pharmacology	p. 53
Receptors for norepinephrine and signal transduction pathways	p. 68
Regulation of gene transcription in the central nervous system by norepinephrine	p. 95
The norepinephrine transporter and regulation of synaptic transmission	p. 119
Norepinephrine and behavior
Role of the locus coeruleus-norepinephrine system in arousal and circadian regulation of the sleep-wake cycle	p. 157
The locus coeruleus and regulation of behavioral flexibility and attention: clinical implications	p. 196
Norepinephrine and long-term memory function	p. 236
Norepinephrine and stress	p. 275
The biology of norepinephrine in CNS pathology
Animal models of psychopathology: focus on norepinephrine	p. 299
Neuropathology of central norepinephrine in psychiatric disorders: postmortem research	p. 341
Norepinephrine in mood disorders	p. 363
Noradrenergic pathology and pain	p. 385
Norepinephrine and cognitive disorders	p. 408
Norepinephrine in neurological disorders	p. 436
Genetics of noradrenergic neurobiology	p. 472
Psychopharmacology of norepinephrine
Actions of antidepressant and other drugs on norepinephrine systems	p. 515
The clinical role of norepinephrine antidepressants in depression and anxiety disorders	p. 535
Norepinephrine in attention-deficit/Hyperactivity disorder	p. 557
Psychopharmacology of norepinephrine in eating disorders	p. 595
Role of norepinephrine in substance abuse	p. 610
Index	p. 628
Table of Contents provided by Ingram. All Rights Reserved.

Brain Norepinephrine

Neurobiology and Therapeutics

At a Glance

Hardcover

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How to return your order

Defective items

You Can Find This Book In

Other Editions and Formats

Paperback

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