Phycotoxins

List of contributors vii

Preface xiii

1 Analysis of marine toxins: gaps on food safety control of marine toxins 1
Paz Otero and Carmen Alfonso

2 Pharmacology of ciguatoxins 23
Carmen Vale, Alvaro Antelo and Victor Martin

3 Chemistry of pinnatoxins 49
Phillip Mabe and Armen Zakarian

4 Chemistry and analysis of PSP toxins 69
Ana Botana and Veronica Rey Lopez

5 Chemistry of palytoxin and its analogues 85
Patrizia Ciminiello, Carmela Dell'Aversano and Martino Forino

6 Pharmacology of palytoxins and ostreocins 113
M. Carmen Louzao, Maria Fraga and Natalia Vilarin? o

7 Recent insights into anatoxin-a chemical synthesis, biomolecular targets, mechanisms of action and LC-MS detection 137
Custodia Fonseca, Manuel Aureliano, Feras Abbas and Ambrose Furey

8 Therapeutics of marine toxins 181
Eva Alonso and Juan A. Rubiolo

9 Marine toxins as modulators of apoptosis 203
Amparo Alfonso, Andrea Fernandez-Araujo and Mercedes R. Vieytes

10 Cyanobacterial toxins 225
Vitor Vasconcelos, Pedro Leão and Alexandre Campos

11 Marine toxins and climate change: the case of PSP from cyanobacteria in coastal lagoons 239
Antonella Luglie, Silvia Pulina, Milena Bruno, Bachisio Mario Padedda, Cecilia Teodora Satta, and Nicola Sechi

12 Microalgae as a source of nutraceuticals 255
Sushanta Kumar Saha, Edward McHugh, Patrick Murray and Daniel J. Walsh

13 The marine origin of drugs 293
Andre Horta, Celso Alves, Susete Pinteus and Rui Pedrosa

14 Pharmacology of cylindrospermopsin 317
Juan A. Rubiolo, Diego Alberto Fernandez, Henar Lopez and M. Carmen Louzao

15 Pharmacology of the cyclic imines 343

Natalia Vilarinõ, Sara F. Ferreiro, Andres Crespo and Jose Gil

16 Diversity of organic structures of marine microbial origin with drug potential 361
Marcel Jaspars, Rainer Ebel and Hai Deng

17 Polyketides as a source of chemical diversity 381
Tanya Beletskaya, Catherine Collins and Patrick Murray

18 Ichthyotoxins 407
John W. La Claire II and Schonna R. Manning

19 Pathological clues of phycotoxin ingestion 463
Manuel Cifuentes, Andres Crespo and Roberto Bermudez

Index 513