Hypocretins

Integrators of Physiological Signals

By: Luis De Lecea, Luis de Lecea (Editor), J. Gregor Sutcliffe (Editor)

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Hardcover | 29 September 2005

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Hardcover
468 Pages

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23.39 x 15.6 x 2.54

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The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with "wide awake" EEG patterns and EMG suppression. The first report linking REM sleep to a pathology occurred in 1961 and a clear association of sleep onset REM periods, cataplexy, hypnagogic hallucinations and sleep paralysis was fully established by 1966. When a naïve individual happens to observe a full-blown cataplexy attack, it is both dramatic and unnerving. Usually the observer assumes that the loss of muscle tone represents syncope or seizure. In order to educate health professionals and the general public, Christian Guilleminault and I made movies of full-blown cataplectic episodes (not an easy task). We showed these movies of cataplexy attacks to a number of professional audiences, and were eventually rewarded with the report of a similar abrupt loss of muscle tone in a dog. We were able to bring the dog to Stanford University and with this as the trigger, we were able to develop the Stanford Canine Narcolepsy Colony. Breeding studies revealed the genetic determinants of canine narcolepsy, an autosomal recessive gene we termed canarc1. Emmanuel Mignot took over the colony in 1986 and began sequencing DNA, finally isolating canarc1 in 1999.

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You Can Find This Book In

Non-Fiction Science Chemistry Organic Chemistry Medicine Clinical & Internal Medicine Neurology & Clinical Neurophysiology Pre-Clinical Medicine & Basic Sciences Physiology Metabolism Biology, Life Sciences Life Sciences in General

Neurosciences

Foreword
Preface
The Discovery Of The Hypocretins
Orexin And Orexin Receptors
Rodent Models Of Human Narcolepsy-Cataplexy
The Canine Model Of Narcolepsy
Anatomy Of The Hypocretin System
The Anatomy Of Hypocretin Neurons
Transmitter-Identified Neurons And Afferent Innervation Of The Lateral Hypothalamic Area
Physiological Characteristics Of Hypocretin/Orexin Neurons
The Ne System As A Target For Hypocretin Neurons: Implications For Regulation Of Arousal
Hypocretin/Orexin Actions On Mesopontine Cholinergic Systems Controling Behavioral State
The Aminergic Systems And The Hypocretins
Effects Of Hypocretin/Orexin On The Thalamocortical Activating
In Vivo Pharmacology Of Orexin (Hypocretin) Receptors
Intracellular Signal Pathways Utilized By The Hypocretin/Orexin Receptors
The Hypocretins And Narcolepsy
An Approach To Determining The Functions Of Hypocretin (Orexin)
Hypocretin In Neuropsychiatric Disorders
Hypocretin/Orexin And Sleep
Modulation Of Cortical Activity And Sleep-Wake States By Hypocretin/Orexin
Regulation Of Hypocretin By Metabolic Signals
Hypocretin And Brain Reward Function
Orexin/Hypocretin And Opioid Dependence
Dopamine
Hypocretin/Orexin Interactions
Hypocretin/Orexin In Stress And Arousal
The Hypocretins/Orexins And The Hypothalamo-Pituitary-Adrenal Axis
Orexins (Hypocretins) In The Gut
Hypocretins In Endocrine Regulation
The Hypocretins In Cardiovascular Regulation
Index
Table of Contents provided by Publisher. All Rights Reserved.

Hypocretins

Integrators of Physiological Signals

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

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