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Histocompatibility Testing

By: Jeffrey L Bidwell (Editor), Cristina Navarrete (Editor)

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Hardcover | 10 March 2000

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Hardcover
492 Pages

Dimensions(cm)
26.04 x 17.78 x 3.18

Hardcover

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This invaluable book provides comprehensive coverage of contemporary serological, cellular and molecular methodologies in histocompatibility testing, and their application to human organ transplantation and transfusion. The contributors are internationally respected authorities in histocompatibility and immunogenetics, and are closely involved in the development or application of state-of-the-art technologies. The first three sections of the book are primarily intended for use as a bench manual for histocompatibility testers, immunologists and immunogeneticists; the fourth and fifth sections, on selection of donors and statistical methods, will further assist medical practitioners involved in clinical transplantation and its outcome. The final section of the book reviews the genetics and clinical relevance of minor histocompatibility antigens.

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You Can Find This Book In

Non-Fiction Medicine Clinical & Internal Medicine Diseases & Disorders Immunology Pre-Clinical Medicine & Basic Sciences Anatomy Histology Other Branches of Medicine Pathology Histopathology Medicine in General

Medical Equipment & Techniques Medical Laboratory Testing & Techniques Science Biology, Life Sciences Booktopia Publisher Services World Scientific Publishing

Foreword: HLA Polymorphism: Origin and Maintenance	p. 1
Introduction: Immune Recognition and the Mhc	p. 11
Antibody-Based Histocompatibility Testing
Overviews	p. 40
HLA Typing by Alloantibodies and Monoclonal Antibodies	p. 49
Screening for HLA-Specific Antibodies	p. 65
Detection of Soluble HLA	p. 99
Crossmatching by Lymphocytotoxicity and Flow Cytometry	p. 125
DNA-Based Histocompatibility Testing
Overview	p. 146
PCR-SSP Typing	p. 149
PCR-SSOP Typing	p. 187
Sequencing-Based Typing	p. 213
DNA Conformational Analysis	p. 247
Microsatellite Typing	p. 267
On-Line HLA Sequence Alignments	p. 293
Cell-Based Histocompatibility Testing
Overview	p. 304
Cell-Based Histocompatibility Testing	p. 307
Donor Selection
Overview	p. 346
Allocation of Solid Organs for Transplantation	p. 349
Selection of Haemopoietic Stem Cell Donors for Transplantation	p. 363
Selection of Platelet Donors and Provision of Hla-Matched Platelets	p. 379
Statistical Methods
Overview	p. 392
Population Genetics of the Human Major Histocompatibility Complex	p. 395
Appendix
Survival Analysis in Solid Organ Transplantation	p. 417
Survival Analysis in Bone Marrow Transplantation	p. 427
Hla and Disease Association: Statistical Considerations	p. 439
Minor Histocompatibility Antigens
Minor Histocompatibility Antigens	p. 454
Index	p. 469
Table of Contents provided by Syndetics. All Rights Reserved.

Histocompatibility Testing

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Hardcover

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