| Glycosyltransferase Genes | |
| Glycosyltransferases | |
| Convenient Synthesis of Glycan-Related Oligosaccharides and Their Transformation into Neoglycoconjugates Using Enzymatic Methods | p. 5 |
| Comparison of Glycosyltransferase Families Using the Profile Hidden Markov Model | p. 9 |
| N-Acetylglucosaminyltransferases Involved in N-Glycan Biosynthesis | p. 13 |
| UDP-N-Acetyl-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferases (ppGaNTases, pp-GalNAc-Ts, EC 2.4.1.41) | p. 16 |
| Glycosyltransferase Family with [beta]4GT Motif ([beta]4Gal-T and [beta]4GalNAc-T Family) | p. 19 |
| [beta]1,3-glycosyltransferase Gene Family and IGnT Gene Family | p. 24 |
| O-Mannosyltransferase and POMGnT1 | p. 30 |
| Glycosyltransferases Involved in O-fucose Glycan Synthesis | p. 33 |
| Fucosyltransferase ([alpha]1,2/ [alpha]1,3/ [alpha]1,4-fucosyltransferases) | p. 36 |
| FUT8 Assay | p. 39 |
| Sialyltransferases | p. 42 |
| Glucuronyltransferases Involved in the HNK-1 Biosynthesis | p. 47 |
| [alpha]1,4-Linkage Glycosyltransferases | p. 50 |
| Glycosyltransferases Involved in the Biosynthesis of Glycolipids | p. 53 |
| Sialyltransferases and Other Enzymes Involved in the Biosynthesis of Gangliosides | p. 56 |
| Heparan Sulfate Synthases and Related Genes | p. 59 |
| Chondroitin Sulfate Biosynthesis and Related Genes | p. 64 |
| Biosynthesis of Keratan Sulfate | p. 67 |
| Hyaluronan Synthase Assay | p. 70 |
| Glycosylphosphatidylinositol-Anchored Protein Biosynthesis and Related Genes in Mammalian Cells | p. 72 |
| Cloning of Genes for N-linked Oligosaccharide Synthesis in Endoplasmic Reticulum | p. 76 |
| Sugar-Modified Enzymes | |
| N-acetylglucosamine-6-O-sulfotransferases | p. 83 |
| Sulfotransferases Involved in Sulfation of Glycosaminoglycans | p. 87 |
| Sulfatide Synthase | p. 94 |
| CMP-N-acetylneuraminic Acid Hydroxylase | p. 97 |
| Transporters | |
| Nucleotide Sugar Transporter Genes and Their Functional Analysis | p. 103 |
| Glycosidases | |
| Processing Enzymes Involved in N-glycan Biosynthesis and Related Genes: the Golgi N-glycan Processing [alpha]-mannosidase II and [alpha]-mannosidase IIx | p. 111 |
| Sialidase Genes | p. 115 |
| Release of Sugar Chains from Glycosphingolipids | p. 119 |
| Heparan Sulfate Endosulfatase Assay | p. 123 |
| Sphingolipid Activator Proteins | p. 125 |
| Animal Lectins | |
| Affinity Purification of Recombinant Galectins | p. 133 |
| Siglec Family | p. 136 |
| Functional Analyses of Sugar Chains | |
| Immunology | |
| NKT Cells and Their Recognition of Glycolipids | p. 145 |
| Carbohydrate Ligands for Selectins in Immune Cell Trafficking | p. 148 |
| Carbohydrate Recognition by Cytokines and Its Relevance to Their Physiological Activities | p. 154 |
| Detection of Mouse MGL1/CD301a by a Specific Monoclonal Antibody | p. 158 |
| Roles of Serum Lectins in Host Defense | p. 162 |
| Siglec-2 Is a Key Molecule for Immune Response | p. 167 |
| Galectin and Immune System: Toward Clinical Applications | p. 171 |
| Brains and Nerves | |
| Novel Glycolipids in Developing Brain: Determination by Nano-LC/MS/MS | p. 177 |
| Functional Roles of the HNK-1 Carbohydrate and Polysialic Acid in the Nervous System | p. 180 |
| Neuronal Function of Sulfatide | p. 182 |
| Accumulation of Alzheimer [beta]-amyloid via Ganglioside Clusters | p. 185 |
| Chondroitin Sulfate Proteoglycans and Neuronal Network Formation | p. 188 |
| Processing of Glycosyltransferases by Alzheimer's [beta]-secretase (BACE1) | p. 192 |
| Chondroitin Sulfate Proteoglycans: A Key Substance for Central Nervous System Injury Repair | p. 195 |
| Quality Control of Proteins | |
| A Cytoplasmic Peptide: N-Glycanase and ER-Associated Degradation | p. 201 |
| Ubiquitination of Glycoproteins in the Cytosol | p. 204 |
| Degradation of Misfolded Glycoproteins in the Endoplasmic Reticulum | p. 207 |
| Golgi and Lysosomal Diseases | |
| Retrograde Transport of Glycolipid-Bound Toxins | p. 213 |
| Degradation of Hyaluronan and Its Disorder | p. 216 |
| Recent Advances in Enzyme Replacement Therapy for Lysosomal Diseases | p. 219 |
| Infections | |
| Developing an Assay System for the Hemagglutinin Mutations Responsible for the Binding of Highly Pathogenic Avian Influenza A Viruses to Human-Type Receptors | p. 225 |
| Helicobacter pylori Growth Assay for Glycans | p. 227 |
| Binding Properties of Clostridium botulinum Type C Progenitor Toxin | p. 230 |
| Cancer | |
| Fucosylation and Cancer | p. 235 |
| Biological Significance of Mucins Produced by Epithelial Cancer Cells | p. 238 |
| Regulation of Glycosyltransferases for O-Glycan Core Structure in Cancer and Their Relations to Metastasis | p. 243 |
| Roles of Carbohydrate-Mediated Cell Adhesion in Cancer Progression | p. 246 |
| Conditional Transgenic Mouse of Hyaluronan Synthase: A Potential Model of Advanced Breast Cancer | p. 252 |
| Regeneration Medicine and Transplantation | |
| Proteoglycans in Tissue Regeneration | p. 257 |
| Stem Cell Glycobiology | p. 262 |
| Human Embryonic Stem (ES) Cells and Induced Pluripotent Stem (iPS) Cells Are Defined by Carbohydrate Markers | p. 265 |
| Glycoantigens in Xenotransplantation | p. 267 |
| Fertilization | |
| Glycoconjugates in Spermatogenesis | p. 275 |
| Recognition Mechanism of Egg and Sperm Based on Sugar Chains | p. 278 |
| Development, Differentiation, and Morphogenesis | |
| Functional Analysis of Sugar Chains Using a Genome-Wide RNAi System in Drosophila | p. 285 |
| Functional Glycomics at the Level of Single Cells: Studying Roles of Sugars in Cell Division, Differentiation, and Morphogenesis with 4D Microscopy | p. 290 |
| Studies on Functions of Notch O-Fucosylation in Drosophila | p. 295 |
| Membrane Microdomain as a Platform of Carbohydrate-Mediated Interactions During Early Development of Medaka Fish | p. 299 |
| Functions of Heparan Sulfate Proteoglycans in Morphogenesis | p. 303 |
| Fukutin and Fukuyama Congenital Muscular Dystrophy | p. 309 |
| Muscle Dystrophy and Carbohydrate Disorders of Glycosylation | |
| Congenital Muscular Dystrophies Due to the Glycosylation Defect | p. 315 |
| Molecular Diagnosis of Congenital Disorders of Glycosylation | p. 319 |
| Research in Japan Has Contributed to the Understanding of GPI Anchor Deficiency | p. 323 |
| Lifestyle-Related Diseases | |
| Aberrant Expression of Sialidase in Cancer and Diabetes | p. 329 |
| Insulin Resistance and Type 2 Diabetes as Microdomain Disease: Implication of Ganglioside GM3 | p. 333 |
| IgA Nephropathy | |
| Incompleteness of O-glycans at the Hinge Region of IgA1 and IgA Nephropathy | p. 339 |
| [beta]4-Galactosyltransferase Deficiency and IgA Nephropathy | p. 343 |
| Glycosyltransferases Involved in the Biosynthesis of IgA O-Glycans | p. 346 |
| Growth Factor Receptors | |
| Importance of Sugar Chains in the Function of Growth Factor Receptors | p. 349 |
| Analysis of N-glycan of Growth Factor Receptors | p. 351 |
| The Midkine Family and Its Receptors | p. 355 |
| V-glycans Regulate Integrin [alpha]5[beta]1 Functions | p. 358 |
| Blood Groups and Blood Cells | |
| Blood Group Antigens: Blood Group Carbohydrate Antigens | p. 363 |
| Bombay, Lewis and Ii Blood Group Antigens on Human Erythrocytes | p. 366 |
| Blood Cells in Glycobiology | p. 369 |
| Glycosyltransferase Gene KO Mice | |
| Glycosyltransferase Gene KO Mice | |
| Fucosyltransferase-9 Knockout Mouse | p. 377 |
| Knockout Mice of [alpha]1,6 Fucosyltransferase (Fut 8) | p. 379 |
| Glucuronyltransferase (GlcAT-P) Gene-Deficient Mice | p. 381 |
| KO Mice of [beta]1,4-galactosyltransferase-I | p. 383 |
| Sulfotransferases | p. 386 |
| KO Mice of Cerebroside Sulfotransferase | p. 389 |
| KO Mice of [beta]1,4-N-acetylgalactosaminyltransferase (GM2/GD2 Synthase) | p. 391 |
| KO Mice of [alpha]-2,8-sialyltransferase (GD3 Synthase) | p. 394 |
| Double KO Mice of [beta]1,4-N-acetylgalactosaminyltransferase (GM2/GD2 Synthase) and [alpha]-2,8-sialyltransferase (GD3 Synthase) | p. 396 |
| Infrastructures and Research Resources | |
| Glycosyltransferases and Related Genes, and Useful Cell Lines | |
| Cell Lines for Glycobiology | p. 403 |
| Sugar Chain-Related Genes: Glycosyltransferases Expression System | p. 407 |
| Sugar Library | |
| GALAXY Database and Pyridylaminated Oligosaccharide Library | p. 413 |
| Mass Production of Sugar Intermediates for the Synthesis of Functional Oligosaccharides | p. 417 |
| Database | |
| A Database System for Glycogenes (GGDB) | p. 423 |
| CabosDB: Carbohydrate Sequencing Database | p. 426 |
| GlycoEpitope: A Database of Carbohydrate Epitopes and Antibodies | p. 429 |
| A Novel Lectin-Affinity Database for Structural Glycomics | p. 432 |
| Glycocon, jugate Data Bank | p. 435 |
| KEGG GLYCAN for Integrated Analysis of Pathways, Genes, and Structures | p. 441 |
| Microarray | |
| DNA Microarray in Glycobiology | p. 447 |
| Lectin Microarray | p. 451 |
| Carbohydrate Microarray for Deciphering the Information Embedded in Oligosaccharide Structures | p. 455 |
| Glossary | p. 459 |
| Index | p. 491 |
| Table of Contents provided by Blackwell. All Rights Reserved. |
