Apoptosome

An Up-And-Coming Therapeutical Tool

By: Francesco Cecconi (Editor), Marcello D'Amelio (Editor)

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Hardcover | 18 December 2009

At a Glance

Hardcover
336 Pages

Dimensions(cm)
23.5 x 15.88 x 1.91

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"Apoptosome" is the first book that presents a concise synthesis of recent developments in the understanding of how the activation of the cell death cascade is handled by a cytosolic signalling platform known as the apoptosome.

The book also discusses how insights into the regulation of apoptosome may be exploited for designing new drugs aimed at interfere with a plethora of pathogenetic processes involved in human diseases.

The authors emphasize novel translational approaches that are rapidly moving from the laboratory bench top to the patient's bedside for the future treatment of diseases associated with apoptosis.

This book will be a valuable resource for researchers investigating the role of apoptosome-dependent cell death in cancer and other diseases, for researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance and for physicians using chemotherapeutic agents. Additionally, this book will be an important educational source for PhD students and MD students specializing in molecular and cell biology, and to anybody interested in science, medicine, as well as in recent developments of the ideas and concepts of the molecular biology of programmed cell death.

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Non-Fiction Science Biology, Life Sciences Cellular Biology Medicine Clinical & Internal Medicine Diseases & Disorders Oncology Other Branches of Medicine Pharmacology Pre-Clinical Medicine & Basic Sciences Nursing & Ancillary Services

Nursing Molecular Biology

Physiological and Pathological Role of Apoptosis	p. 1
Apoptosome Structure and Regulation	p. 27
Chemical Regulation of the Apoptosome: New Alternative Treatments for Cancer	p. 41
Molecules That Bind a Central Protein Component of the Apoptosome, Apaf-1, and Modulate Its Activity	p. 75
Regulation of Cell Death and Survival by RNA Interference - The Roles of miRNA and siRNA	p. 95
Beneficial Role of Taurine Against Myocardial Apoptosis During Ischemic Injury	p. 119
BAG3 Protein: Role in Some Neoplastic Cell Types and Identification as a Candidate Target for Therapy	p. 137
Targeting Survivin in Cancer Therapy: Pre-clinical Studies	p. 147
Hsp 70 and Hsp 27: Emerging Targets in Cancer Therapy	p. 169
Role of the RNA-Binding Protein HuR in Apoptosis and Apoptosome Function	p. 203
Acetylcholinesterase as a Pharmacological Target in Cancer Research	p. 221
Putative Role of HCA66, A New Apaf-1 Interacting Protein, in the Physiopathology of NF1 Microdeletion Syndrome Patients	p. 237
Cristae Remodeling and Mitochondrial Fragmentation: A Checkpoint for Cytochrome c Release and Apoptosis?	p. 253
Apoptosome Pharmacological Manipulation: From Current Developments in the Laboratory to Clinical Implications	p. 271
The Therapeutic Role of Taurine in Ischaemia-Reperfusion Injury	p. 283
Targeting Survivin in Cancer Therapy: Clinical Considerations	p. 305
Index	p. 321
Table of Contents provided by Ingram. All Rights Reserved.

Apoptosome

An Up-And-Coming Therapeutical Tool

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

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