Toxicogenomics

A Powerful Tool for Toxicity Assessment

By: Saura C. Sahu

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eText | 20 November 2008 | Edition Number 1

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Toxicogenomics is the integration of genomics to toxicology. This technology is a powerful tool for collecting information from a large number of biological samples simultaneously and thus it is very useful for large-scale screening of potential toxicants.

Toxicogenomics: A Powerful Tool For Toxicity Assessment provides up-to-date state-of-the-art information presented by the recognized experts, and is therefore an authoritative source of current knowledge in this field of research. The potential link between toxicology, genetics and human diseases makes this book very useful to investigators in many and varied disciplines of science and toxicology. Topics covered include:

mechanistic toxicogenomics
analysis and interpretation of toxicogenomic data
principles of data mining in toxicogenomics
design issues in toxicogenomics studies
sources of variability in toxicogenomic assays
Escherichia coli stress response as a tool for detection of toxicity
toxicogenomics as a tool to assess immunotoxicity
toxicogenomics and ecogenomics for studying endocrine disruption and basic biology
use of toxicogenomics as an early predictive tool for hepatotoxicity
nutrigenomics: the application of genomic signatures in nutrition-related research
application of toxicogenomics in drug discovery
potential uses of toxicogenomic biomarkers in occupational health and risk assessment
usefulness of toxicogenomics in the regulatory environment
perspectives on toxicogenomics at the US Environmental Protection Agency

Toxicogenomics: A Powerful Tool For Toxicity Assessment ?? is an essential resource for research scientists currently engaged in toxicogenomics, and will also be of interest to researchers working in toxicology, genetics, medicine, pharmacology, and food sciences, and to regulators and risk assessors of drug, food, environmental and agricultural products.