Progress in Inflammation Research

From Laboratory to Clinical Practice

By: Slobodan Vukicevic (Editor), Kuber Sampath (Editor)

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Hardcover | 1 May 2002

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344 Pages

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23.39 x 15.6 x 2.06

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From the basic science to potential and approved clinical applications the most recent data in the rapidly growing field of bone morphogenetic proteins (BMPs) are summarized in this topical volume. Distinguished scientists present reviews on a range of scientific topics, including biochemistry, biology, molecular biology and preclinical animal studies on spinal fusion, cartilage repair, craniofacial and dental reconstruction using BMPs, as well as approved clinical applications in human bone non-unions.

This book provides a resource not only for experts in the field, but also for undergraduate students, newcomers and clinicians worldwide, given that the use of BMPs in orthopedic reconstruction has been already approved in Europe, Australia, Canada and the USA.

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Published: 23rd October 2012

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List of contributors	p. vii
Preface	p. xi
Biochemistry of bone morphogenetic proteins	p. 1
Prostate-derived factor and growth and differentiation factor-8: newly discovered members of the TGF-[beta] superfamily	p. 19
Bone morphogenetic protein receptors and their nuclear effectors in bone formation	p. 31
Deciphering the binding code of BMP-receptor interaction	p. 61
Biology of bone morphogenetic proteins	p. 87
Preclinical models of recombinant BMP induced healing of orthopedic defects	p. 121
Osteogenic protein-1 (OP-1, BMP-7) for stimulation of healing of closed fractures: evidence based medicine and pre-clinical experience	p. 145
Maxillofacial reconstruction	p. 157
Bone morphogenetic proteins in periodontal regeneration	p. 183
Osteogenic protein-1 (OP-1) in the repair of bone defects and fractures of long bones: clinical experience	p. 193
Evaluation of OP-1 in a rabbit model of lumbar fusions	p. 207
Bone morphogenetic proteins and the synovial joints	p. 223
BMPs in articular cartilage repair	p. 249
The role of bone morphogenetic proteins in kidney development and repair	p. 263
Effects of bone morphogenetic proteins on neural tissues	p. 289
Index	p. 321
Table of Contents provided by Syndetics. All Rights Reserved.

Progress in Inflammation Research

From Laboratory to Clinical Practice

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Hardcover

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