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Progress in Inflammation Research

By: Giancarlo Folco (Editor), Bengt Samuelsson (Editor), Robert C. Murphy (Editor)

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Hardcover | 1 September 1999

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Hardcover
364 Pages

Dimensions(cm)
23.39 x 15.6 x 2.06

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Many new antileukotriene drugs are now marketed as antiasthma drugs and represent the first new drugs in this field since the 1970s. This book covers the steps that have led to the discovery and development of these new drugs and offers detailed descriptions of their clinical applications. The review chapters on the main aspects of basic and applied leukotriene research are written by leading specialists in the field, and the volume takes a new approach in presenting information of particular interest to both scientists and clinicians in the fields of asthma, inflammation and allergic diseases.

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You Can Find This Book In

Non-Fiction Medicine Other Branches of Medicine Pharmacology Family & Health Clinical & Internal Medicine Diseases & Disorders Immunology Pre-Clinical Medicine & Basic Sciences Respiratory Medicine Science Biology, Life Sciences

Human Biology Pathology Histopathology Medicine in General

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Paperback

Published: 23rd October 2012

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List of contributors
5-Lipoxygenase	p. 1
LTC[subscript 4] synthase: A key enzyme in cysteinyl leukotriene formation	p. 23
Leukotriene A[subscript 4] hydrolase: A key enzyme in chemotactic leukotriene formation	p. 45
Metabolism of leukotrienes and formation of new leukotriene structures	p. 63
Receptors for cysteinyl-leukotrienes: Targets for new drugs	p. 83
Targeted disruption of 5-lipoxygenase	p. 101
Transcellular biosynthesis of leukotrienes: A unique mode of cell communication	p. 113
Physiological and pathophysiological activities of leukotrienes	p. 125
Entry rate and metabolic handling of LTC[subscript 4] in the human circulation	p. 139
Genetic polymorphisms of 5-LO	p. 147
Leukotrienes and aspirin-intolerant asthma	p. 165
Leukotrienes in nocturnal asthma	p. 177
Leukotrienes and allergic asthma	p. 185
Inhibitors of leukotrienes: An overview	p. 205
The development of zafirlukast (Accolate) and the Zeneca series of peptidyl-leukotriene receptor antagonists	p. 215
The development of zileuton (ZYFLO) and the N-hydroxyurea class of 5-lipoxygenase inhibitors	p. 235
The development of BAY X 1005 and the Bayer series of leukotriene biosythesis inhibitors	p. 251
The development of iralukast: A member of the Novartis series of cysteinyl leukotriene antagonists	p. 269
LTB[subscript 4] receptor antagonists	p. 299
SmithKline Beecham pharmaceuticals' cysteinyl leukotriene receptor antagonists: Pranlukast (SB 205312; Ono-1078; Onon), Pobilukast (SKandF 104353) and SKandF 106203	p. 317
Index	p. 343
Table of Contents provided by Blackwell. All Rights Reserved.

Progress in Inflammation Research

At a Glance

Hardcover

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How to return your order

Defective items

You Can Find This Book In

Other Editions and Formats

Paperback

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