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Ocular Oncology - Daniel M. Albert

Ocular Oncology

By: Daniel M. Albert (Editor), Arthur Polans (Editor)

Hardcover Published: 26th August 2003
ISBN: 9780824740160
Number Of Pages: 492

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Survival rates in cases of uveal melanoma and retinoblastoma - the leading intraocular malignancies in adults and children - may be high, but means of earlier diagnosis and improved treatment options are needed to preserve vision and prevent metastasis. This reference deals principally with the molecular biology and genetic factors which trigger and promote the two most common ocular tumours.

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The editors have accomplished an important goal by presenting state-of-the-art clinical ocular oncology alongside voluminous amounts of information on the pathobiology of uveal melanoma and retinoblastoma.This book should be available to every person who cares for patients with uveal melanoma or retinoblastoma, or who works in a laboratory trying to understand why healthy cells become cancerous.

Prefacep. v
Contributorsp. xi
Clinical Overview of Uveal Melanoma: Introduction to Tumors of the Eyep. 1
Clinical Overview: Retinoblastomap. 19
Epidemiology of Uveal Melanoma: Patient Characteristics, Risk Factors, and Predisposing Elementsp. 35
Epidemiology of Retinoblastomap. 47
Genetics of Uveal Melanoma: Chromosomal Rearrangements and the Identification of Genes Involved in Tumorigenesisp. 63
Structural Alterations and Gene Expression in the Pathogenesis of Uveal Melanomap. 81
A Cascade of Genomic Changes Leads to Retinoblastomap. 103
The Role of the Retinoblastoma Protein in Health, Malignancy, and the Pathogenesis of Retinoblastomap. 129
Biochemical Pathways: Differential Gene Expression and Cellular Pathways Determining Tumor Phenotype Comparison of Uveal Melanocytes and Uveal Melanoma Cells In Vitrop. 189
p53 and the Molecular Regulation of Cell Fate in Retinoblastomap. 211
Immunology of Uveal Melanoma: Adaptive Antitumor Immunity and the Basis for Immunotherapyp. 231
Immunology of Uveal Melanoma: Immunosuppressive Factors and the Basis for Immunotherapyp. 255
Models of Uveal Melanoma: Characterization of Transgenic Mice and Other Animal Models for Melanomap. 269
Using Retinoblastoma Models to Develop New Treatment: Vitamin D Analoguesp. 297
Therapy of Uveal Melanoma: Methods and Risk Factors Associated with Treatmentp. 321
The Treatment of Retinoblastomap. 353
Clinical Trials in Uveal Melanoma: Patient Characteristics and the Treatment of Intraocular Tumorsp. 377
Clinical Trials in Retinoblastomap. 401
Pathology of Uveal Melanoma: Histological Parameters and Patient Prognosisp. 407
Retinoblastoma: Pathology and Prognosisp. 427
Molecular Genetics of Retinoblastomap. 449
Genetically Engineered Mouse Models of Retinoblastomap. 465
Treatment of Extraocular Retinoblastomap. 489
Indexp. 499
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9780824740160
ISBN-10: 0824740165
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 492
Published: 26th August 2003
Publisher: Taylor & Francis Inc
Country of Publication: US
Dimensions (cm): 24.5 x 17.0  x 3.18
Weight (kg): 1.13
Edition Number: 1

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