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Actin Polymerization in Apicomplexan

A Structural, Functional and Evolutionary Analysis

By: Avinash Kale (Editor)

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Paperback | 26 November 2019

At a Glance

Paperback
116 Pages

Dimensions(cm)
23.5 x 15.49 x 0.79

Paperback

$169.00

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This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements.

The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPÎ± and CPÎ²), cyclase-associated protein (CAP) and coronin 13-24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design.

Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.

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