CONTENTS
Contributors vii
Preface to the Eleventh Edition xv
Preface to the First Edition xvii
section I
The Normal Thyroid 1
A. History, Development, Anatomy 1
chapter 1 The heritage of the thyroid: A brief history 1
Peter A. Kopp
chapter 2 Development and anatomy of the hypothalamic–pituitary–thyroid axis 9
Pilar Santisteban and Sabine Costagliola
B. Thyroid Hormone Synthesis and Secretion 39
chapter 3 Thyroid hormone synthesis: Thyroid iodide transport 39
Nancy Carrasco
chapter 4 Thyroid hormone synthesis 59
Peter A. Kopp
C. Peripheral Thyroid Hormone Binding and Metabolism 86
chapter 5 Thyroid hormone transport proteins 86
David Halsall and Carla Moran
chapter 6 Intracellular pathways of iodothyronine metabolism/implications of deiodination
for thyroid hormone action 97
Antonio C. Bianco and Brian W. Kim
D. Thyroid Hormone Action 128
chapter 7 Intracellular actions by thyroid hormones 128
Paul M. Yen, Gregory A. Brent, and Anthony N. Hollenberg
chapter 8 Thyroid hormone structure–function relationships 143
Riccardo Zucchi
E. Factors That Control Thyroid Function 157
chapter 9 Chemistry and biosynthesis of thyrotropin 157
Ronald N. Cohen, Anthony N. Hollenberg, and Fredric E. Wondisford
chapter 10 The thyrotropin receptor 174
Gilbert Vassart and Patrice Rodien
chapter 11 Aging and the thyroid 183
Anne R. Cappola
chapter 12 Effects of drugs on TSH secretion, thyroid hormones’ absorption, synthesis,
metabolism, and action 187
David H. Sarne
chapter 13 Thyroid disruptors 203
Angela M. Leung
chapter 14 Nonthyroidal illness syndrome 214
Anita Boelen, Lies Langouche, Wilmar Wiersinga, and Greet Van den Berghe
chapter 15 Iodine deficiency and excess, endemic cretinism 230
Michael B. Zimmermann and Weiping Tengxx Contents
section II
Assessment of Thyroid Structure and Function 259
chapter 16 Physical examination of the thyroid gland 259
James V. Hennessey and Jeffrey R. Garber
chapter 17 Laboratory measurement of thyroid-related hormones, proteins, and autoantibodies in serum 267
Ulla Feldt-Rasmussen
chapter 18 Nonisotopic thyroid imaging 300
Gilles Russ and Jung Hwan Baek
chapter 19 Thyroid radionuclide uptake and imaging studies 310
Daniel A. Pryma
chapter 20 Cytopathology of the thyroid gland 321
Zubair W. Baloch and Virginia A. Livolsi
chapter 21 Histopathology of the thyroid gland 332
Zubair W. Baloch and Virginia A. Livolsi
section III
Thyroid Diseases: Thyrotoxicosis 353
A. Causes of Thyrotoxicosis 353
chapter 22 Pathogenesis of Graves disease 353
Terry F . Davies and Yaron Tomer
chapter 23 Thyrotropin-induced thyrotoxicosis 370
Paolo Beck-Peccoz, Andrea Lania, and Luca Persani
chapter 24 Toxic adenoma and toxic multinodular goiter 378
Ralf Paschke
chapter 25 Trophoblastic tumors 389
Jerome M. Hershman
chapter 26 Sporadic painless, painful subacute and acute infectious thyroiditis 395
Alan P . Farwell and Elizabeth N. Pearce
chapter 27 Thyrotoxicosis of extrathyroidal origin 414
Angela M. Leung
B. Organ System Manifestations 419
chapter 28 Overview of the clinical manifestations of thyrotoxicosis 419
Henry B. Burch
chapter 29 Ophthalmopathy 427
Luigi Bartalena
chapter 30 The cardiovascular system in thyrotoxicosis 438
Salman Razvi
chapter 31 Thyroid hormones in intermediary metabolism, thermogenesis, and obesity 446
Francesco S. Celi
chapter 32 The skeletal system in thyrotoxicosis 454
Bernard Freudenthal, Laura Watts, Graham R. Williams, and J. H. Duncan Bassett
chapter 33 Thyroid dermopathy and thyroid acropachy 463
Vahab Fatourechi
chapter 34 Psychiatric and cognitive effects of thyrotoxicosis 476
Mary H. Samuels and Kathryn G. Schuff
chapter 35 Thyrotoxic storm 482
Leonard Wartofsky and Kenneth D. Burman
C. Diagnosis and Management of Thyrotoxicosis 489
chapter 36 Diagnosis of thyrotoxicosis 489
Paul W. Ladenson
chapter 37 Treatment of thyrotoxicosis 495
David S. Cooper
chapter 38 Subclinical thyrotoxicosis 524
Kristien BoelaertContents xxi
section IV
Thyroid Diseases: Hypothyroidism 531
A. Causes of Hypothyroidism 531
chapter 39 Chronic autoimmune thyroiditis 531
Anthony P . Weetman
chapter 40 Genetic defects causing hypothyroidism 543
N. Schoenmakers
chapter 41 Primary hypothyroidism due to other causes 555
Caroline T. Nguyen and Peter A. Singer
chapter 42 Central hypothyroidism 566
Luca Persani and Paolo Beck-Peccoz
B. Organ System Manifestations of Hypothyroidism 575
chapter 43 Overview of the clinical manifestations of hypothyroidism 575
Michael T. McDermott
chapter 44 Hypothyroidism and the heart 584
Salman Razvi
chapter 45 The skeletal system in hypothyroidism 592
Laura Watts, Bernard Freudenthal, J.H. Duncan Bassett, and Graham R. Williams
chapter 46 Psychiatric and cognitive effects of hypothyroidism 599
Kathryn G. Schuff and Mary H. Samuels
chapter 47 Myxedema Coma 605
Kenneth D. Burman and Leonard Wartofsky
C. Management of Hypothyroidism 612
chapter 48 Diagnosis of hypothyroidism 612
Paul W. Ladenson
chapter 49 Treatment of hypothyroidism 618
Jacqueline Jonklaas
chapter 50 Subclinical hypothyroidism 635
Robin P . Peeters
section V
Thyroid Diseases: Nontoxic Diffuse and Multinodular Goiter 641
chapter 51 Multinodular goiter: pathogenesis and management 641
Steen Joop Bonnema and Laszlo Hegedüs
chapter 52 Clinical evaluation and management of thyroid nodules 660
Susan J. Mandel and Jill E. Langer
section VI
Thyroid Cancers 683
chapter 53 Carcinomas of follicular epithelium: epidemiology and pathogenesis 683
Arthur B. Schneider, Cari M. Kitahara, and Alina Brenner
chapter 54 Genomic landscapes of thyroid cancers of follicular cell derivation 709
David G. McFadden, Thomas Giordano, James A. Fagin, and Yuri Nikiforov
chapter 55 Carcinoma of the follicular epithelium: surgical therapy 723
David L. Steward and Julie A. Sosa
chapter 56 Staging and prognosis of differentiated thyroid cancer 733
Donald S.A. McLeod
chapter 57 Medical management of differentiated epithelial cell thyroid cancer 751
Sebastiano Filetti, R. Michael Tuttle, and Steven I. Sherman
chapter 58 Papillary microcarcinomas 776
Akira Miyauchi and Yasuhiro Ito
chapter 59 Medullary thyroid cancer 784
Andreas Machens, Dagmar Führer, and Henning Drallexxii Contents
chapter 60 Poorly differentiated thyroid cancer, anaplastic thyroid cancer, and miscellaneous tumors of the
thyroid 796
Bryan R. Haugen, Keith C. Bible, and Robert C. Smallridge
chapter 61 Thyroid cancer in children 813
Catherine A. Dinauer, Emily R. Christison-Lagay, and Gary L. Francis
section VII
The Thyroid in Infancy and Childhood 839
chapter 62 The maturation of thyroid function in the fetus, in the perinatal period and during childhood 839
Gabor Szinnai and Michel Polak
chapter 63 Hypothyroidism in infants and children 855
Johnny Deladoëy, Julia von Oettingen, and Guy Van Vliet
chapter 64 Impaired sensitivity to thyroid hormone: defects of transport, metabolism, and action 868
Alexandra M. Dumitrescu, Manassawee Korwutthikulrangsri, and Samuel Refetoff
chapter 65 Hyperthyroidism in the neonate, child, and adolescent 908
Scott A. Rivkees
section VIII
Thyroid Disorders in Pregnancy and Postpartum 923
chapter 66 Thyroid disorders during preconception, pregnancy, and the postpartum period 923
Tim I.M. Korevaar and Elizabeth N. Pearce
Index 943
