The GnRH Neuron and its Control

List of Contributors vii

Series Preface xi

Preface xiii

About the Companion Website xv

Part I Historical Introduction to the GnRH Neuron

1 The Framework Upon Which Current Research on the GnRH Neuron and its Control is Built 3
Tony M. Plant and Allan E. Herbison

Part II GnRH Neuron Development

2 Prenatal Development of GnRH Neurons 15
Yufei Shan and Susan Wray

3 Fetal/perinatal Programming Causing Sexual Dimorphism of the Kisspeptin¢"GnRH NeuronalNetwork 43
Hiroko Tsukamura, Kei¢ichiro Maeda and Yoshihisa Uenoyama

4 Postnatal Development of GnRH Neuronal Function 61
Ei Terasawa

Part III GnRH Neuron Biology

5 Regulation of GnRH Gene Expression 95
Hanne M. Hoffmann and Pamela L. Mellon

6 Morphology of the Adult GnRH Neuron 121
Rebecca E. Campbell

7 The Anatomy of the GnRH Neuron Network in the Human 149
Katalin Skrapits and Erik Hrabovszky

8 Electrophysiology of Rodent GnRH Neurons 177
Richard Piet and Allan E. Herbison

9 Anatomy and Physiology of GnRH Neurons and Their Control of Pituitary Function in Fish 203
Yoshitaka Oka

Part IV Regulation of GnRH Neuron Function

10 Unveiling the Importance of Glia and Vascular Endothelial Cells in the Control of GnRH NeuronalFunction 227
Vincent Prevot and Ariane Sharif

11 Genetic Strategies Examining Kisspeptin Regulation of GnRH Neurons 259
Michael Candlish, Philipp Wartenberg and Ulrich Boehm

12 KNDy Hypothesis for Generation of GnRH Pulses: Evidence from Sheep and Goats 289
Robert L. Goodman, Satoshi Okhura, Hiroaki Okamura,  Lique M. Coolen and Michael N. Lehman

13 Generation of the GnRH Surge and LH Surge by the Positive Feedback Effect of Estrogen 325
Iain Clarke

14 Influence of Stress on the GnRH Neuronal Network 357
Pasha Grachev and Kevin T. O¢Byrne

15 Metabolic Regulation of GnRH Neurons 383
Maggie C. Evans and Greg M. Anderson

16 Seasonal Control of the GnRH Neuronal Network as a Means of Uncovering Novel CentralMechanisms Governing Mammalian Reproduction 411
S©bastien Milesi, Paul Klosen and Valerie Simonneaux

Part V GnRH in the Clinic

17 Human Genetics of GnRH Neuron Function 445
A. Kemal Topaloglu and L. Damla Kotan

18 Modulators of GnRH Secretion and Therapeutic Applications 469
Claire L. Newton, Ross C. Anderson and Robert P. Millar

Index 499