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The GnRH Neuron and its Control

By: Allan E. Herbison (Editor), Tony M. Plant (Editor)

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Hardcover | 27 April 2018 | Edition Number 1

At a Glance

Hardcover
536 Pages

Dimensions(cm)
24.38 x 16.51 x 2.79

Hardcover

$391.75

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GnRH has been recognized as a key molecule in the central control of reproduction for a long period. During the last decade, the appearance of new, and critical, regulators of GnRH release, e.g. kisspeptin and NKB, together with the boom in new and potent techniques in neuroscience to explore the function and development of neuronal circuits, has led to an tremendous wealth of new data that has significantly advanced our understanding of the physiology of the central regulation of GnRH release.

The GnRH Neuron and its Control will examine the developmental biology of GnRH neurons including their birth in the nasal placode of the early embryo, perinatal programming and sexual differentiation, in addition to the hypothalamic mechanisms that control GnRH neurons in adulthood to generate pulsatile and surge modes of GnRH secretion throughout the major life stages including ageing. The morphology, electrophysiology, signal transduction pathways, transcriptional regulators and genomics underlying function of the adult GnRH neuron will be discussed in detail, as will the neuroendocrinology and cell biology governing the generation of both modes of GnRH release. The neurobiological mechanisms and circuitry responsible for the modulation of the activity of GnRH neurons by season, stress, nutrition and metabolism will also be critically reviewed, as will current and potential therapeutic approaches to regulating GnRH secretion and action.

Integrating newly identified research and classical fundamental knowledge to GnRH biology, this book will provide students, researchers and practitioners with an in-depth understanding of reproductive neuroendocrinology.

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