Tamoxifen

Beyond the Antiestrogen

By: John A. Kellen

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Hardcover | 1 April 1996

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Hardcover
392 Pages

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24.77 x 16.51 x 2.54

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Tamoxifen has persisted as a widely accepted and administered drug for almost 25 years. Following the many scientific papers and books on the subject, it has remained a very intriguing substance. This, perhaps, is the reason for another monograph on Tamoxifen. It is regrettably true that overviews, even when up to date after exhaustive research - the shibboleth of our cultures -, rapidly lose relevance with the passage of time. Scientists can sometimes be pictured as deep sea divers, who plunge into the unknown in search of a hitherto unknown world. Their descent is exciting, but eventually they must come up for air and integrate their experiences with others who also had to resurface. This book intends to collect and, where possible, to collate recent, but sometimes seemingly unrelated information. To quote Stephane Mallarme: "Everything in the world exists to end up in a book". Even if this is a tad cynical, it might not be far from the truth. If a little knowledge is a dangerous commodity, one can also add - tongue in cheek - that a vast amount of knowledge can be truly hazardous. It is likely that what might seem as entangled data is confusing, especially for those satisfied with the comfortable interpretation of Tamoxifen as an antiestrogen which has long been found insufficient. The complexity of its mechanisms and effects defies simple explanations and may even seem capricious, but only because of our ignorance.

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You Can Find This Book In

Non-Fiction Medicine Clinical & Internal Medicine Diseases & Disorders Oncology Chemotherapy Other Branches of Medicine Pharmacology Endocrinology Pre-Clinical Medicine & Basic Sciences Physiology Metabolism

Gynaecology & Obstetrics Medicine in General

Other Editions and Formats

Paperback

Published: 26th September 2011

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Preface
List of Contributors
Introduction: the enigma of Tamoxifen	p. 1
Assessing Neoplasia	p. 25
Interactions of Tamoxifen with lipid signal transduction cascades	p. 43
Carcinogenicity of Tamoxifen	p. 59
Mechanisms of resistance to antiestrogens and their implications for crossresistance	p. 93
Tamoxifen and multidrug resistance in cancer	p. 123
The effect of Tamoxifen on the immune response	p. 137
Cellular effects of early exposure to Tamoxifen	p. 179
The covalent binding of Tamoxifen to proteins and DNA	p. 201
Tamoxifen metabolism and receptor function - implications for mechanisms of resistance in breast cancer	p. 231
Tamoxifen and E-cadherin/catenin complex	p. 267
Regulation of growth factor gene expression by Tamoxifen	p. 285
Tamoxifen and drug-metabolising enzymes	p. 303
Membrane antioxidant-mediated cardioprotective actions of amoxifen	p. 321
Antiestrogen regulation of erbB2 expression in human breast cancer cells	p. 343
Enhancement of the antineoplastic effects of Tamoxifen by somatostatin analogues	p. 359
Conclusions	p. 369
Index	p. 375
Table of Contents provided by Blackwell. All Rights Reserved.

Tamoxifen

Beyond the Antiestrogen

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

Other Editions and Formats

Paperback

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