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Synthetic Multivalent Molecules : Concepts and Biomedical Applications - Seok-Ki Choi

Synthetic Multivalent Molecules

Concepts and Biomedical Applications

Hardcover Published: 3rd September 2004
ISBN: 9780471563471
Number Of Pages: 448

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This book provides basic principles of multivalent interactions found in biological systems as well as an up-to-date and thorough coverage in design concepts, syntheses, and biological activities of multivalent molecules.<br> * Contains practical examples of synthetic multivalent molecules in chemistry, biology, and medicine<br> * Can be used as both a textbook for students and a reference book for libraries and professionals<br> * Includes detailed case studies<br> * Fills a void in current literature through its devotion solely to multivalent molecules

Industry Reviews

??an excellent compilation of multivalent systems and their biological applications.? (ChemBioChem, 2005; Vol. 6; 7)

"This authoritative information reference?will fit into the library collections at research universities, medical schools and (bio) pharmaceutical companies." (E-STREAMS, March 2005)

"?a fine attempt to provide in one volume all of the various aspects of the field, and it presents a wealth of information on topics that are difficult to find elsewhere?" (Journal of Medicinal Chemistry, February 24, 2005)


Notes for Organization and Classification.


1 Introduction.

1.1 Nomenclature and Definitions.

1.2 Mechanistic Aspects of Multivalent Interaction.

1.3 Biological Roles of Multivalent Ligands.

2 Multivalent Molecules Applied to Viral Targets.

2.1 Influenza Virus.

2.2 Human Immunodeficiency Virus.

2.3 Rotavirus.

2.4 Polyoma Virus.

2.5 Picorna Virus.

2.6 Respiratory Syncytial Virus.

2.7 Dengue Virus.

2.8 Nucleic Acids of Viruses.

2.9 Synthetic Multivalent Vaccines.

3 Multivalent Molecules Applied to Bacterial Targets.

3.1 Targets in Bacterial Cell Membranes.

3.2 Bacterial Toxins.

3.3 Bacterial Enzymes.

3.4 Bacterial Nucleic Acids.

3.5 Multivalent Molecules as Synthetic Vaccines.

3.6 Fungal Cells.

4 Multivalent Molecules Applied to Cellular Targets.

4.1 Carbohydrate-Recognition Receptors on Cell Surfaces.

4.2 Peptide and Hormone Recognition Receptors on Cell Surfaces.

4.3 Ligand-Mediated Receptor Dimerization.

4.4 Enzymes.

4.5 G-Protein-Coupled Receptors.

4.6 Ion Channels.

4.7 Nucleic Acids.

4.8 Antibodies.

4.9 Cell Surface Engineering.

5 Chemical Synthesis of Multivalent Molecules.

5.1 Selected Synthetic Methods for Multimerization.

5.2 Combinatorial Chemistry.


Table 1. Divalent Ligands Linked to Enzymes in Human Immunodeficiency Virus (HIV).

Table 2. Multivalent Ligands Linked to gp120 Surface Receptors in Human Immunodeficiency Virus.

Table 3. Multivalent Ligands Linked to Surface Receptors on Viruses.

Table 4. Multivalent Receptors Targeting Multivalent Ligands in Bacterial Cell Walls.

Table 5. Multivalent Ligands Targeting Bacterial Receptors in Membrane Surfaces.

Table 6. Multivalent Ligands Linked to Bacterial Toxins.

Table 7. Multivalent Molecules Targeting Bacterial Enzymes.

Table 8. Multivalent Ligands Targeting Carbohydrate-Recognition Receptors on Cellular Surfaces.

Table 9. Multivalent Ligands Targeting Noncarbohydrate-Recognition Receptors on Cellular Surfaces.

Table 10. Multivalent Ligands Linked to Selectins on Cell Surfaces.

Table 11. Multivalent Ligands Linked to Lectins.

Table 12. Multivalent Ligands Linked to Cellular Enzymes.

Table 13. Multivalent Ligands Linked to G-Protein-Coupled Receptors (GPCRs).

Table 14. Multivalent Ion Channel?Binding Molecules.

Table 15. Homo- and Heterodivalent Chemical Inducers of Dimerization (CIDs).

Table 16. Multivalent Ligands Linked to Nucleic Acids.

Table 17. Synthetic Multivalent Antigens.

Table 18. Multivalent Ligands Displayed on Self-Assembled Monolayer (SAM) Made of Alkanethiolate on Gold.

Table 19. (Bio)chemical Modification of Cell Surface Antigens.

Table 20. Multivalent Targets.



ISBN: 9780471563471
ISBN-10: 0471563471
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 448
Published: 3rd September 2004
Publisher: John Wiley & Sons Inc
Country of Publication: US
Dimensions (cm): 24.13 x 16.23  x 2.57
Weight (kg): 0.73
Edition Number: 1

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