Losing the Weight Loss Meds

A 10-Week Playbook for Stopping GLP-1 Medications Without Regaining the Weight

By: Holly R. Wyatt, James O. Hill

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Paperback | 16 December 2025

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240 Pages

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22.9 x 15.3 x 2.4

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Innovative weight loss medications are transforming how doctors treat obesity, diabetes, high cholesterol, and more—but while these drugs can help you lose weight, the hardest part is keeping the weight off when you stop taking them.

That’s why, when you’re shifting away from GLP-1 meds, you need a game plan.

Research shows that most people on weight loss drugs like Ozempic, Wegovy, and Zepbound quickly regain their weight when they stop taking medication. Whether you end treatment due to not feeling great, undesirable side effects, loss of insurance coverage, or you just want to keep your weight off without medication, without a plan in place when your body’s natural hunger returns, you risk regaining it all.

Leading weight loss maintenance researchers Holly Wyatt, MD, and James Hill, PhD, share key strategies for using food, movement, and mindset to replace the medication and support long-term weight loss maintenance through an adaptable 10-week transition plan.

Chock-full of specific, actionable strategies for sustainable, lasting success, Losing the Weight Loss Meds offers everything you need to:

Develop an eating plan that maximizes satiety and minimizes “food noise”
Use movement to restore your metabolism to one that is more flexible and that burns more calories
Adjust your mindstate to become more resilient to better overcome obstacles and find joy in the weight loss maintenance process
Effectively troubleshoot weight fluctuations before they result in significant regain
Create and maintain a life you love

By embracing the journey and having a strategic plan, you can maintain your new healthier weight with ease—so you never have to worry about weight loss again.

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