Platelets

Foreword A Brief History of Ideas About Platelets in Health and Disease / Barry S. Coller

Part One: Platelet Biology 1. The Evolution of Mammalian Platelets / Jack Levin 2. Megakaryocyte Development and Platelet Formation / Joseph E. Italiano Jr. 3. The regulation of platelet life span / Benjamin T. Kile 4. Platelet Genomics / Willem Ouwehand, Paul F. Bray 5. Platelet MicroRNAs / Patrick Provost 6. The Platelet Proteome / Andrew S. Weyrich 7. Platelet Structure / James G. White 8. The Platelet Cytoskeleton / John H. Hartwig 9. Platelet Receptors / Kenneth J. Clemetson 10. The GPIb-IX-V Complex / Michael C. Berndt 11. GPVI and CLEC-2 / Steve P. Watson, Alice Y. Pollitt, Craig E. Hughes 12. Integrin AlphaIIb Beta3 / Edward F. Plow 13. Protease-activated Receptors / Athan Kuliopulos, Ping Zhang, Lidija Covic 14. The Platelet P2 Receptors / Marco Cattaneo 15. PECAM-1 / Peter J. Newman, Debra Newman 16. Interactions Between Platelets, Leukocytes and the Endothelium / Susan S. Smyth 17. Inhibition of Platelet Function by the Endothelium / Jane E. Freedman 18. Platelet Secretion / Robert Flaumenhaft 19. Signal Transduction During Platelet Plug Formation / Lawrence F. Brass 20. Platelet Thrombus Formation in Flowing Blood / Zaverio M. Ruggeri 21. Interactions Between Platelets and the Coagulation System / Paula B. Tracy 22. Platelet-Derived Microparticles / Rienk Nieuwland 23. The Role of Platelets in Fibrinolysis / Nicola J. Mutch 24. The Role of Platelets in Angiogenesis / Giannoula Lakka Klement, Ela Shai, David Varon 25. Platelet Function in the Newborn / Sara J. Israels

Part Two: Tests of Platelet Function 26. Clinical Tests of Platelet Function / Paul Harrison 27. Platelet Counting / Paul Harrison 28. Platelet Aggregation / Catherine Pauline Hayward, Karen A. Moffat 29. Flow Cytometry / Alan D. Michelson 30. Monitoring of Antiplatelet Therapy / Paul A. Gurbel, Udaya S. Tantry 31. Real Time In Vivo Imaging of Platelets During Thrombus Formation / Bruce Furie, Barbara Furie

Part Three: The Role of Platelets in Disease 32. Atherothrombosis and Coronary Artery Disease / Meinrad Gawaz 33. Central Nervous System Ischemia / Gregory J. del Zoppo 34. Peripheral Vascular Disease / Michael Sobel 35. Diabetes Mellitus / Giovanni Davi 36. Inflammation / Guy Zimmerman 37. Antimicrobial Host Defense / Michael R. Yeaman, Arnold Bayer 38. Tumor Growth and Metastasis / Jerry Ware

Part Four: Disorders of Platelet Number and Function 39. The Clinical Approach to Disorders of Platelet Number and Function / Alan D. Michelson 40. Immune Thrombocytopenia (ITP) / James B. Bussel, Bethan Psaila 41. Drug-induced Thrombocytopenia / Richard H. Aster 42. Heparin-induced Thrombocytopenia / Andreas Greinacher, Theodore Warkentin, Beng H. Chong 43. Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome / Han-Mou Tsai 44. Thrombocytopenia in Pregnancy / Keith R. McCrae 45. Thrombocytopenia in the Newborn / Irene A.G. Roberts 46. Alloimmune Thrombocytopenia / Cecile Kaplan, Heyu Ni, John Freedman 47. Inherited Thrombocytopenias / Mortimer Poncz, Michele P. Lambert and Ravichandran Mohan 48. Pseudothrombocytopenia / Nicola Bizzaro 49. Thrombocytosis and Essential Thrombocythemia / Ayalew Tefferi 50. Congenital Disorders of Platelet Function / Marco Cattaneo 51. Acquired Disorders of Platelet Function / A. Koneti Rao 52. Cardiopulmonary Bypass / Brian Richard Smith, Henry M. Rinder, Christine S. Rinder

Part Five: Antiplatelet Therapy 53. Aspirin / Carlo Patrono 54. ADP Receptor Antagonists / Marco Cattaneo 55. AlphaIIb Beta3 (GPIIb-IIIa) Antagonists / Anthony A. Bavry 56. Dipyridamole / Wolfgang G. Eisert 57. Cilostazol / Yasuo Ikeda, Toshiki Sudo 58. Novel Antiplatelet Therapies / Deepak L. Bhatt

Part Six: Therapy to Increase Platelet Numbers and/or Function 59. Thrombopoietin Mimetics / David J. Kuter 60. Desmopressin / Pier Mannuccio Mannucci 61. Factor VIIa / Man-Chiu Poon 62. Platelet Transfusion Medicine / Peter L. Perrotta, Jeremy Parsons, Henry M. Rinder, Edward L. Snyder 63. Making Platelets Ex Vivo / Mortimer Poncz, Spencer Sullivan, Michele P. Lambert 64. Gene Therapy for Platelet Disorders / David A. Wilcox