Foreword.
Preface.
Contributors.
Chapter 1. Barriers to Oral Bioavailability-An Overview (Ming
Hu and Xiaoling Li).
Chapter 2. Physicochemical Characterization of Pharmaceutical
Solids (Smita Debnath).
Chapter 3. Solubility of Pharmaceutical Solids (Lauren Wiser,
Xiaoling Gao, Bhaskara Jasti, and Xiaoling Li).
Chapter 4. In Vitro Dissolution of Pharmaceutical Solids
(Josephine L. P. Soh and Paul W. S. Heng).
Chapter 5. Biological and Physiological Features of the
Gastrointestinal Tract Relevant to Oral Drug Absorption (Paul C.
Ho).
Chapter 6. Absorption of Drugs via Passive Diffusion and
Carrier-Mediated Pathways (Miki Susanto Park and Jae H.
Chang).
Chapter 7. In vitro-In vivo Correlation of Pharmaceutical
Dosage Forms (Deliang Zhou and Yihong Qiu).
Chapter 8. Drug Metabolism in Gastroinestinal Tract (Rashim
Singh and Ming Hu).
Chapter 9. Efflux of Drugs via Transporters: The
?Anti-absorption? Pathways (Jae H. Chang, James A.
Uchizono and Miki Susanto Park).
Chapter 10. Liver Drug Metabolism (Leslie M. Tompkins, and
Hongbing Wang).
Chapter 11. Protein Binding of Drugs (Antonia Kotsiou and
Christine Tesseromatis).
Chapter 12. Urinary Excretion of Drugs and Drug Reabsorption
(Pankaj Gupta, Bo Feng and Jack Cook).
Chapter 13. Pharmacokinetic Behaviors of Orally Administered
Drugs (Jaime A. Yanez, Dion R. Brocks, M. Laird
Forrest, and Neal M. Davies).
Chapter 14. Effects of Food on Drug Absorption (Venugopal P.
Marasanapalle, Xiaoling Li, and Bhaskara R. Jasti).
Chapter 15. Drug-Drug Interactions and Drug-Dietary Chemical
Interactions (Ge Lin, Zhong Zuo, Na Li, and Li Zhang).
Chapter 16. Anatomical and Physiological Factors Affecting Oral
Drug Bioavailability in Rates, Dogs, and Humans (Ayman
El-Kattan, Susan Hurst, Joanne Brodfuehrer, Cho-Ming Loi).
Chapter 17. Amino Acid Drug Transporters (Zhong Qiu Liu, and
Ming Hu).
Chapter 18. Drug Transporters and Their Role in Absorption and
Disposition of Peptides and Peptide Based Pharmaceuticals (David
J. Lindley, Stephen M. Carl, Dea Herrera-Ruiz, Li F. Pan, Lori B.
Ward, Jonathan M. E. Goole, Olafur S. Gudmundsson, and Gregory T.
Knipp).
Chapter 19. Organic Anion and Cation Drug Transporters
(Takashi Sekine and Hiroshi Kusuhara).
Chapter 20. Gastroretentive Drug Delivery Systems (John R.
Cardinal and Avinash Nangia).
Chapter 21. Lipid Based and self-emulsifying Oral Drug Delivery
Systems (Sravan Penchala, Anh-Nhan Pham, Ying Huang and Jeffrey
Wang).
Chapter 22. Prodrug Strategies to Enhance Oral Drug Absorption
(Sai H.S. Boddu, Deep Kwatra, and Ashim K. Mitra).
Chapter 23. Oral Delivery of Protein/Peptide Therapeutics
(Puchun Liu and Steven Dinh).
Chapter 24. ABC Transporters in Intestinal and Liver Efflux
(Marilyn E. Morris and Yash A. Gandhi).
Chapter 25. Interplay between Efflux Transporter and Metabolic
Enzymes (Stephen Wang).
Chapter 26. Regulatory Considerations in Metabolism- and
Transporter-Based Drug Interactions (Yuanchao (Derek) Zhang, Lei
Zhang, John M. Strong, Shiew-Mei Huang).
Chapter 27. Caco-2 Cell Culture Model for Oral Drug Absorption
(Kaustubh Kulkarni and Ming Hu).
Chapter 28. MDCK Cells and Other Cell Culture Models of Oral
Drug Absorption (Deep Kwatra, Sai H. S. Boddu, Ashim K.
Mitra).
Chapter 29. Intestinal Perfusion Methods for Oral Drug
Absorption (Wei Zhu and Eun-Jung (Zenobia) Jeong).
Chapter 30. Liver Perfusion and Primary Hepatocytes for Studying
Drug Metabolism and Metabolite Excretion (Cindy Q. Xia, Chuang
Lu, and Suresh K. Balani).
Chapter 31. In vivo Methods for Oral Bioavailability Studies
(Ana Ruiz-Garcia and Marival Bermejo).
Chapter 32. Determination of Regulation of Drug Metabolizing
Enzymes and Transporters (Bin Zhang and Wen Xie).
Chapter 33. Computational and Pharmacoinformatic Approaches to
Oral Bioavailability Prediction (Miguel Angel
Cabrera-Perez, and Isabel Gonzalez-Alvarez).
Index.
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