Nonlinear Models for Repeated Measurement Data

Hardcover | 1 June 1995 | Edition Number 1

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Nonlinear measurement data arise in a wide variety of biological and biomedical applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the analysis of assay and laboratory data.
Nonlinear Models for Repeated Measurement Data provides the first unified development of methods and models for data of this type, with a detailed treatment of inference for the nonlinear mixed effects model and its extensions.
A particular strength of the book is the inclusion of several detailed case studies from the areas of population pharmacokinetics and pharmacodynamics, immunoassay and bioassay development and the analysis of growth curves.

Industry Reviews

"gives a very well-written account of the field over the past few decades, focussing mainly on US work and including much of the author's own, plus a glimpse of the future. It fairly reflects that literature over the years in dwelling at length on certain compuational methods for maximum likelihood estimation. There is aleaning toward biopharmaceutical applications, this being a field in which the authors are acknowledged authorities. There are no exercises, but enough detail of the methodology is given, together with helpful guidance on available software, to enable the keen novice to try his hand. Lastly, I hope I'll be forgiven for just adding a couple of citations to those given in the book: a slightly different perspective on nonlinear regression models for repeated measures is described briefly in Crowder and Hand (1990, Section 9.4) and at greater length in Hand and Crowder (1995, chapter 8). --M. J. Crowder, Biometrics, September 1997

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