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New Developments in NMR : New Developments in NMR - Koichi  Kato

New Developments in NMR

By: Koichi Kato (Editor), Thomas Peters (Editor)

Hardcover | 17 May 2017

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This volume focuses on solution and solid-state NMR of carbohydrates, glycoproteins, glyco-technologies, biomass and related topics. It is estimated that at least 80% of all proteins are glycoproteins. Because of the complexity, heterogeneity and flexibility of the sugar chains, the structural biology approaches for glycoconjugates have been generally avoided. NMR techniques although well established for structural analyses of proteins and nucleic acids, cannot be simply applied to this complex class of biomolecules. Nonetheless, recently developed NMR techniques for carbohydrates open the door to conformational studies of a variety of sugar chains of biological interest. NMR studies on glycans will have significant impact on the development of vaccines, adjuvants, therapeutics, biomarkers and on biomass regeneration.

In this volume, the Editors have collected the most up-to-date NMR applications from experts in the field of carbohydrate NMR spectroscopy. Timely and useful, not only for NMR specialists, it will appeal to researchers in the general field of structural biology, biochemistry and biophysics, molecular and cellular biology and material science.

Focusing on solution and solid-state NMR of carbohydrates, glycoproteins, glyco-technologies, biomass and related topics which will have significant impact on the development of therapeutic agents eg vaccines, this volume is timely and useful not only for NMR specialists but also for a broader scientific community. The precise analysis of glycosylation patterns in humans can be used in therapies of utmost importance. However, the complexity and heterogeneity of dynamic glycan structures often discouraged researchers from actively challenging and addressing this important issue. Written by leading experts in the field, this book is an important contribution to the literature in this area for a wide spectrum of readers.

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