| Introduction to Compartmental Analysis | p. 1 |
| Concept of Compartments | p. 1 |
| Living Systems | p. 1 |
| Thermodynamics and Entropy | p. 3 |
| Fundamental Solution | p. 6 |
| Limitations of Compartmental Analysis | p. 6 |
| Single Tissue Compartment Analysis | p. 7 |
| Two Tissue Compartment Analysis | p. 9 |
| Compartmental Assumptions | p. 9 |
| Combined Compartments | p. 12 |
| Arteries and Veins | p. 13 |
| Three Tissue Compartment Analysis | p. 14 |
| Compartmental Assumptions | p. 15 |
| Combined Compartments | p. 20 |
| Fundamentals of Compartmental Kinetics | p. 23 |
| Definition of Relaxation Constants | p. 23 |
| Single Compartment | p. 24 |
| Two Compartments | p. 25 |
| Two Compartments with Sink | p. 28 |
| Three Compartments | p. 30 |
| Three Compartments with Sink | p. 34 |
| Four or More Compartments | p. 36 |
| Multiple Compartments in Series and in Parallel | p. 39 |
| Interpretation of Relaxation Constants | p. 42 |
| Flow | p. 42 |
| Passive Diffusion | p. 43 |
| Properties of Delivery Compartment | p. 49 |
| Protein-Ligand Interaction | p. 56 |
| Receptor Binding | p. 61 |
| Facilitated Diffusion | p. 63 |
| Enzymatic Reactions | p. 67 |
| Determination of Relaxation Constants | p. 70 |
| Stimulus-Response Relations | p. 70 |
| Regression Analysis | p. 71 |
| Deconvolution of Response Function by Differentiation | p. 73 |
| Deconvolution by Temporal Transformation | p. 75 |
| Deconvolution of Response Function by Linearization | p. 86 |
| Application of Relaxation Constants | p. 91 |
| Peroxidation | p. 91 |
| Dopaminergic Neurotransmission | p. 91 |
| Analysis of Neuroreceptor Binding In Vivo | p. 103 |
| The Receptor Concept | p. 103 |
| The Compartment Concept | p. 105 |
| Compartmental Analysis | p. 105 |
| The Basic Equation | p. 106 |
| The Basic Solution | p. 107 |
| Two-Compartment (Permeability) Analysis | p. 108 |
| Analysis of K1 and k2 | p. 108 |
| Physiological Definitions of K1 and k2 | p. 110 |
| Three-Compartment (Binding) Analysis | p. 111 |
| Analysis of k3 and k4 | p. 111 |
| Molecular Definitions of k3 and k4 | p. 115 |
| Inhibition | p. 118 |
| The Problem of Solubility and Nonspecific Binding | p. 120 |
| The Problem of Labeled Metabolites | p. 122 |
| In Vivo Analysis of Binding | p. 122 |
| Irreversible Binding: Determination of k3 | p. 122 |
| Reversible Binding: Determination of Binding Potential (pB) | p. 124 |
| Equilibrium Analysis: Determination of Bmax and KD | p. 126 |
| Neuroreceptor Mapping In Vivo: Monoamines | p. 131 |
| Introduction | p. 131 |
| Monoaminergic Neurotransmission | p. 131 |
| Methods of Neuroreceptor Mapping | p. 133 |
| Tracers of Monoaminergic Neurotransmission | p. 136 |
| Pharmacokinetics of Monoaminergic Neurotransmission | p. 140 |
| Altered Monoaminergic Neurotransmission | p. 145 |
| Dopamine | p. 146 |
| Serotonin | p. 149 |
| Design of Monoaminergic Drugs | p. 151 |
| Conclusions | p. 151 |
| Blood-Brain Transfer and Metabolism of Oxygen | p. 153 |
| Introduction | p. 153 |
| Blood-Brain Transfer of Oxygen | p. 154 |
| Capillary Model of Oxygen Transfer | p. 154 |
| Compartment Model of Oxygen Transfer | p. 157 |
| Oxygen in Brain Tissue | p. 159 |
| Cytochrome Oxidation | p. 159 |
| Mitochondrial Oxygen Tension | p. 161 |
| Flow-Metabolism Coupling of Oxygen | p. 165 |
| Limits to Oxygen Supply | p. 167 |
| Distributed Model of Insufficient Oxygen Delivery | p. 168 |
| Compartment Model of Insufficient Oxygen Delivery | p. 171 |
| Experimental Results | p. 172 |
| Brain Tissue and Mitochondrial Oxygen Tensions | p. 172 |
| Flow-Metabolism Coupling | p. 173 |
| Ischemic Limits of Oxygen Diffusibility | p. 176 |
| Blood-Brain Glucose Transfer | p. 177 |
| Brief History | p. 177 |
| Brain Endothelial Glucose Transporter | p. 178 |
| Molecular Biology | p. 178 |
| Molecular Kinetics | p. 180 |
| Structural Requirements of Glucose Transport | p. 181 |
| Theory of Blood-Brain Glucose Transfer | p. 182 |
| Apparent Permeability and Flux | p. 183 |
| Facilitated Diffusion | p. 186 |
| Multiple Membranes | p. 189 |
| Evidence of Blood-Brain Glucose Transfer | p. 191 |
| Methods | p. 192 |
| Normal Values in Awake Subjects | p. 196 |
| Acute Changes of Glucose Transport | p. 201 |
| Chronic Changes | p. 206 |
| Metabolism of Glucose | p. 211 |
| Basic Principles of Metabolism | p. 211 |
| Glycolysis | p. 212 |
| Oxidative Phosphorylation | p. 214 |
| Gluconeogenesis | p. 214 |
| Glycogenesis and Glycogenolysis | p. 215 |
| Pentose-Phosphate Pathway | p. 215 |
| Kinetics of Steady-State Glucose Metabolism | p. 215 |
| Kinetics of Deoxyglucose Metabolism | p. 217 |
| Irreversible Metabolism | p. 219 |
| Lumped Constant | p. 220 |
| Reversible Metabolism | p. 221 |
| Operational Equations | p. 224 |
| Irreversible Metabolism of Deoxyglucose | p. 224 |
| Reversible Metabolism of Fluorodeoxyglucose | p. 229 |
| Metabolism of Tracer Glucose | p. 231 |
| Glucose Metabolic Rates | p. 233 |
| Lumped Constant Variability | p. 235 |
| Whole-Brain Glucose Consumption | p. 237 |
| Regional Brain Glucose Consumption | p. 238 |
| Neuroenergetics | p. 241 |
| Brain Work | p. 241 |
| Ion Homeostasis | p. 242 |
| Brain Energy Metabolism | p. 244 |
| Definition of Brain Activity Levels | p. 244 |
| Stages of Brain Metabolic Activity | p. 246 |
| Substrate Transport in Brain | p. 248 |
| Glucose Transport | p. 248 |
| Monocarboxylate Transport | p. 249 |
| Oxygen Transport | p. 250 |
| ATP Homeostasis | p. 252 |
| Hydrolysis of Phosphocreatine | p. 253 |
| Glycolysis | p. 253 |
| Oxidative Phosphorylation | p. 256 |
| Metabolic Compartmentation | p. 259 |
| Functional Properties of Neurons and Astrocytes | p. 259 |
| Metabolic Properties of Neurons and Astrocytes | p. 260 |
| Activation | p. 265 |
| Ion Homeostasis During Activation | p. 266 |
| Brain Energy Metabolism During Activation | p. 267 |
| Substrate Delivery During Activation | p. 273 |
| ATP Homeostasis During Activation | p. 281 |
| Metabolic Compartmentation During Activation | p. 286 |
| Conclusions | p. 288 |
| Glossary | p. 291 |
| References | p. 301 |
| Index | p. 335 |
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