Preface ix
Acknowledgments xi
Contributors xiii
PART I BASICS OF MOLECULAR IMAGING AND NANOBIOTECHNOLOGY
1. Basic Principles of Molecular Imaging 3
Sven H. Hausner
2. Synthesis of Nanomaterials as a Platform for Molecular Imaging 25
Jinhao Gao, Jin Xie, Bing Xu, and Xiaoyuan Chen
3. Nanoparticle Surface Modification and Bioconjugation 47
Jin Xie, Jinhao Gao, Mark Michalski, and Xiaoyuan Chen
4. Biodistribution and Pharmacokinetics of Nanoprobes 75
Nagesh Kolishetti, Frank Alexis, Eric M. Pridgen, and Omid C. Farokhzad
PART II NANOPARTICLES FOR SINGLE MODALITY MOLECULAR IMAGING
5. Computed Tomography as a Tool for Anatomical and Molecular Imaging 107
Pingyu Liu, Hu Zhou, and Lei Xing
6. Carbon Nanotube X-Ray for Dynamic Micro-CT Imaging of Small Animal Models 139
Otto Zhou, Guohua Cao, Yueh Z. Lee, and Jianping Lu
7. Quantum Dots for In Vivo Molecular Imaging 159
Yun Xing
8. Biopolymer, Dendrimer, and Liposome Nanoplatforms for Optical Molecular Imaging 183
David Pham, Ling Zhang, Bo Chen, and Ella Fung Jones
9. Nanoplatforms for Raman Molecular Imaging in Biological Systems 197
Zhuang Liu
10. Single-Walled Carbon Nanotube Near-Infrared Fluorescent Sensors for Biological Systems 217
Jingqing Zhang and Michael S. Strano
11. Microparticle- and Nanoparticle-Based Contrast-Enhanced Ultrasound Imaging 233
Nirupama Deshpande and J¨urgen K. Willmann
12. Ultrasound-Based Molecular Imaging Using Nanoagents 263
Srivalleesha Mallidi, Mohammad Mehrmohammadi, Kimberly Homan, Bo Wang, Min Qu, Timothy Larson, Konstantin Sokolov, and Stanislav Emelianov
13. MRI Contrast Agents Based on Inorganic Nanoparticles 279
Hyon Bin Na and Taeghwan Hyeon
14. Cellular Magnetic Labeling with Iron Oxide Nanoparticles 309
Sebastien Boutry, Sophie Laurent, Luce Vander Elst, and Robert N. Muller
15. Nanoparticles Containing Rare Earth Ions: A Tunable Tool for MRI 333
C. Rivi`ere, S. Roux, R. Bazzi, J.-L. Bridot, C. Billotey, P. Perriat, and O. Tillement
16. Microfabricated Multispectral MRI Contrast Agents 375
Gary Zabow and Alan Koretsky
17. Radiolabeled Nanoplatforms: Imaging Hot Bullets Hitting Their Target 399
Raffaella Rossin
PART III NANOPARTICLE PLATFORMS AS MULTIMODALITY IMAGING AND THERAPY AGENTS
18. Lipoprotein-Based Nanoplatforms for Cancer Molecular Imaging 433
Ian R. Corbin, Kenneth Ng, and Gang Zheng
19. Protein Cages as Multimode Imaging Agents 463
Masaki Uchida, Lars Liepold, Mark Young, and Trevor Douglas
20. Biomedical Applications of Single-Walled Carbon Nanotubes 481
Weibo Cai, Ting Gao, and Hao Hong
21. Multifunctional Nanoparticles for Multimodal Molecular Imaging 529
Yanglong Hou and Rui Hao
22. Multifunctional Nanoparticles for Cancer Theragnosis 541
Seulki Lee, Ick Chan Kwon, and Kwangmeyung Kim
23. Nanoparticles for Combined Cancer Imaging and Therapy 565
Vaishali Bagalkot, Mi Kyung Yu, and Sangyong Jon
24. Multimodal Imaging and Therapy with Magnetofluorescent Nanoparticles 593
Jason R. McCarthy and Ralph Weissleder
25. Gold Nanocages: A Multifunctional Platform for Molecular Optical Imaging and Photothermal Treatment 615
Leslie Au, Claire M. Cobley, Jingyi Chen, and Younan Xia
26. Theranostic Applications of Gold Nanoparticles in Cancer 639
Parmeswaran Diagaradjane, Pranshu Mohindra, and Sunil Krishnan
27. Gold Nanorods as Theranostic Agents 659
Alexander Wei, Qingshan Wei, and Alexei P. Leonov
28. Theranostic Applications of Gold Core–Shell Structured Nanoparticles 683
Wei Lu, Marites P. Melancon, and Chun Li
29. Magnetic Nanoparticle Carrier for Targeted Drug Delivery: Perspective, Outlook, and Design 709
R. D. K. Misra
30. Perfluorocarbon Nanoparticles: A Multidimensional Platform for Targeted Image-Guided Drug Delivery 725
Gregory M. Lanza, Shelton D. Caruthers, Anne H. Schmieder, Patrick M. Winter, Tillmann Cyrus, and Samuel A. Wickline
31. Radioimmunonanoparticles for Cancer Imaging and Therapy 755
Arutselvan Natarajan
PART IV TRANSLATIONAL NANOMEDICINE
32. Current Status and Future Prospects for Nanoparticle-Based Technology in Human Medicine 783
Nuria Sanvicens, Fatima Fernandez, J.-Pablo Salvador, and M.-Pilar Marco
Index 815
