My Wish Lists Login / Join

Molecular Biology Intelligence Unit

By: Jesus Paramio (Editor)

Write A Review

Hardcover | 9 June 2006

At a Glance

Hardcover
164 Pages

Dimensions(cm)
23.39 x 15.6 x 1.12

Hardcover

$249.00

or 4 interest-free payments of $62.25 with

Ships in 5 to 7 business days

Intermediate Filaments focuses on desmin and other intermediate filaments in disease and health. This new volume will serve as a resource for graduate students and researchers in the field.

Shipping

	Standard Shipping	Express Shipping
Metro postcodes:	$9.99	$14.95
Regional postcodes:	$9.99	$14.95
Rural postcodes:	$9.99	$14.95

Orders over $89.00 qualify for free shipping.

How to return your order

At Booktopia, we offer hassle-free returns in accordance with our returns policy. If you wish to return an item, please get in touch with Booktopia Customer Care.

Additional postage charges may be applicable.

Defective items

If there is a problem with any of the items received for your order then the Booktopia Customer Care team is ready to assist you.

For more info please visit our Help Centre.

You Can Find This Book In

Non-Fiction Science Biology, Life Sciences Life Sciences in General Genetics excluding Medical Medicine Other Branches of Medicine Pathology Medical Microbiology & Virology Cellular Biology Pre-Clinical Medicine & Basic Sciences Anatomy

Molecular Biology

Preface	p. ix
Desmin and Other Intermediate Filaments in Normal and Diseased Muscle	p. 1
Desmin in Mature Skeletal and Heart Muscle Cells	p. 1
Desmin and Other IF Proteins in Different Muscles	p. 2
Functions of Desmin in Striated Muscles	p. 4
Function of Desmin in Smooth Muscles	p. 5
Gene Regulation	p. 5
Desmin-Related Myopathies (DRM)	p. 6
Intermediate Filaments in Astrocytes in Health and Disease	p. 10
IFs in Astroglial Cells during Development	p. 10
GFAP and Its Regulation	p. 11
Vimentin and Nestin and Their Regulation	p. 13
Formation of IFs in Astroglial Cells	p. 13
Astrocyte IFs, CNS Trauma and Regeneration	p. 16
Astrocyte IFs and Resistance to Mechanical Stress	p. 22
Astrocyte IFs, Osmotic Stress and Ischemia/Hypoxia	p. 25
Astrocyte IFs, Cell Proliferation and Tumorigenesis	p. 25
GFAP Mutations and Alexander Disease	p. 26
Neuronal Intermediate Filaments and Neurodegenerative Diseases	p. 35
Neuronal Intermediate Filament Proteins	p. 36
Neuronal IFs in Neurodegenerative Diseases	p. 38
Neurofilaments: Phosphorylation and Signal Transduction	p. 52
Neurofilaments Are Members of the Intermediate Filament Family	p. 53
Neurofilaments and Axonal Caliber	p. 55
Phosphorylation of Neurofilaments	p. 55
Neurofilaments and Their Associated Kinases	p. 56
Neurofilament Tail Domain Phosphorylation	p. 57
Axonal Transport of Neurofilaments	p. 58
Phosphorylation of NFs and Disease	p. 59
Neurofilaments and Signal Transduction Pathways	p. 60
Keratin Intermediate Filaments and Diseases of the Skin	p. 74
Epidermal Blistering Caused by Keratin Mutations	p. 74
Candidate Genes in Other Epithelia	p. 75
From Candidate Genes to "Candidate Diseases"	p. 77
Supramolecular Stability versus Molecular Flux	p. 77
Keratin Filaments as Tensile Structures	p. 78
Significance of Keratin Role in Skin Fragility Disorders	p. 79
The Keratin K6 Minifamily of Genes	p. 83
Conservation of Sequence in the K6 Polypeptides	p. 84
Expression of the K6 Genes	p. 87
Expression and Partners	p. 89
Functional Considerations	p. 89
Transcriptional Regulation of Keratin Gene Expression	p. 93
Transcriptional Regulation of Keratin K5 Expression	p. 93
Regulation of K14	p. 95
Regulation of K15	p. 96
Regulation of K1 and K10	p. 96
Regulation of K4 and K13	p. 97
Regulation of K3 and K12	p. 98
Regulation of Hair Keratins	p. 99
Regulation of Keratin Gene Expression by Hormones and Vitamins	p. 99
Regulation of Keratin Gene Expression by Growth Factors and Cytokines	p. 101
Regulation of Small Keratins, K7, K8, K18 and K19	p. 101
Specific Transcription Factors Implicated in Regulation of Transcription of Keratin Genes	p. 103
Conclusions and Future Directions	p. 105
Simple Epithelial Keratins: Expression, Function and Disease	p. 110
Suggested Functions of Simple Epithelial Keratins	p. 111
Simple Epithelial Keratin Proteins and Disease	p. 114
Altered Simple Epithelial Keratin Expression and Cancer	p. 115
Keratins as Targets in and Modulators of Liver Diseases	p. 120
The Keratin Cytoskeleton of Hepatocytes and Bile Duct Epithelial Cells	p. 120
Alterations of the Keratin Cytoskeleton in Human Liver Diseases	p. 121
Animal Models to Study Hepatocytic Keratin Alterations	p. 122
Mallory Bodies as a Product of the Cellular Response to Misfolded Keratin	p. 124
How Can Keratins Influence Toxic Cell Injury?	p. 125
Mutations of Keratin Genes and Liver Diseases	p. 127
The Search for Specific Keratin Functions: The Case of Keratin K10	p. 131
Keratin K10 Assembly and Dynamics	p. 132
Keratin K10 Inhibits Cell Proliferation	p. 134
Transgenic Mice Models to Study K10 Functions	p. 138
The Paradigms of K10 Knock Out Model	p. 139
Reconciling Hypotheses	p. 141
Index	p. 147
Table of Contents provided by Ingram. All Rights Reserved.

Molecular Biology Intelligence Unit

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

More in Pathology

Understanding Pathophysiology ANZ + Elsevier Adaptive Quizzing

4th Edition - Includes Elsevier Adaptive Quizzing for Understanding Pathophysiology

Integrative Approach to Fungal Infections and Bioprospecting for Drug Discovery

Volume 2

Robbins & Kumar Basic Pathology

11th Edition

Acute and Chronic Hemolytic Diseases

Mechanisms and Pathology

Pathophysiology of Heart Disease

8th Edition - An Introduction to Cardiovascular Medicine

Robbins, Cotran & Kumar Pathologic Basis of Disease

Robbins Pathology

Pocket Companion to Robbins & Cotran Pathologic Basis of Disease

10th edition

Identity Unknown

The gripping new Kay Scarpetta thriller for 2024

Porth's Pathophysiology

11th Edition - Concepts of Altered Health States

Robbins and Cotran Review of Pathology

5th Edition

The Washington Manual of Surgical Pathology

3rd edition

Pathophysiology Made Incredibly Easy!

Incredibly Easy! Series®

Mims' Medical Microbiology and Immunology

7th Edition

Unnatural Causes

When the Dust Settles

THE SUNDAY TIMES BESTSELLER. 'A marvellous book' - Rev Richard Coles

Mills and Sternberg's Diagnostic Surgical Pathology

7th Edition

Atlas of Lymph Node Pathology

A Pattern Based Approach

Medical Microbiology

9th Edition

Pathophysiology

7th Edition

Agrios' Plant Pathology

6th Edition

Microbiology with Diseases by Body System, Global Edition

4th edition

Costanzo Physiology

7th edition

Gould's Pathophysiology for the Health Professions

7th Edition

Parasitology

2nd Edition - A Conceptual Approach

This product is categorised by