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Molecular Biology Intelligence Unit

By: Jesus Paramio (Editor)

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Hardcover | 9 June 2006

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Hardcover
164 Pages

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23.39 x 15.6 x 1.12

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Intermediate Filaments focuses on desmin and other intermediate filaments in disease and health. This new volume will serve as a resource for graduate students and researchers in the field.

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Non-Fiction Science Biology, Life Sciences Life Sciences in General Genetics excluding Medical Medicine Other Branches of Medicine Pathology Medical Microbiology & Virology Cellular Biology Pre-Clinical Medicine & Basic Sciences Anatomy

Molecular Biology

Preface	p. ix
Desmin and Other Intermediate Filaments in Normal and Diseased Muscle	p. 1
Desmin in Mature Skeletal and Heart Muscle Cells	p. 1
Desmin and Other IF Proteins in Different Muscles	p. 2
Functions of Desmin in Striated Muscles	p. 4
Function of Desmin in Smooth Muscles	p. 5
Gene Regulation	p. 5
Desmin-Related Myopathies (DRM)	p. 6
Intermediate Filaments in Astrocytes in Health and Disease	p. 10
IFs in Astroglial Cells during Development	p. 10
GFAP and Its Regulation	p. 11
Vimentin and Nestin and Their Regulation	p. 13
Formation of IFs in Astroglial Cells	p. 13
Astrocyte IFs, CNS Trauma and Regeneration	p. 16
Astrocyte IFs and Resistance to Mechanical Stress	p. 22
Astrocyte IFs, Osmotic Stress and Ischemia/Hypoxia	p. 25
Astrocyte IFs, Cell Proliferation and Tumorigenesis	p. 25
GFAP Mutations and Alexander Disease	p. 26
Neuronal Intermediate Filaments and Neurodegenerative Diseases	p. 35
Neuronal Intermediate Filament Proteins	p. 36
Neuronal IFs in Neurodegenerative Diseases	p. 38
Neurofilaments: Phosphorylation and Signal Transduction	p. 52
Neurofilaments Are Members of the Intermediate Filament Family	p. 53
Neurofilaments and Axonal Caliber	p. 55
Phosphorylation of Neurofilaments	p. 55
Neurofilaments and Their Associated Kinases	p. 56
Neurofilament Tail Domain Phosphorylation	p. 57
Axonal Transport of Neurofilaments	p. 58
Phosphorylation of NFs and Disease	p. 59
Neurofilaments and Signal Transduction Pathways	p. 60
Keratin Intermediate Filaments and Diseases of the Skin	p. 74
Epidermal Blistering Caused by Keratin Mutations	p. 74
Candidate Genes in Other Epithelia	p. 75
From Candidate Genes to "Candidate Diseases"	p. 77
Supramolecular Stability versus Molecular Flux	p. 77
Keratin Filaments as Tensile Structures	p. 78
Significance of Keratin Role in Skin Fragility Disorders	p. 79
The Keratin K6 Minifamily of Genes	p. 83
Conservation of Sequence in the K6 Polypeptides	p. 84
Expression of the K6 Genes	p. 87
Expression and Partners	p. 89
Functional Considerations	p. 89
Transcriptional Regulation of Keratin Gene Expression	p. 93
Transcriptional Regulation of Keratin K5 Expression	p. 93
Regulation of K14	p. 95
Regulation of K15	p. 96
Regulation of K1 and K10	p. 96
Regulation of K4 and K13	p. 97
Regulation of K3 and K12	p. 98
Regulation of Hair Keratins	p. 99
Regulation of Keratin Gene Expression by Hormones and Vitamins	p. 99
Regulation of Keratin Gene Expression by Growth Factors and Cytokines	p. 101
Regulation of Small Keratins, K7, K8, K18 and K19	p. 101
Specific Transcription Factors Implicated in Regulation of Transcription of Keratin Genes	p. 103
Conclusions and Future Directions	p. 105
Simple Epithelial Keratins: Expression, Function and Disease	p. 110
Suggested Functions of Simple Epithelial Keratins	p. 111
Simple Epithelial Keratin Proteins and Disease	p. 114
Altered Simple Epithelial Keratin Expression and Cancer	p. 115
Keratins as Targets in and Modulators of Liver Diseases	p. 120
The Keratin Cytoskeleton of Hepatocytes and Bile Duct Epithelial Cells	p. 120
Alterations of the Keratin Cytoskeleton in Human Liver Diseases	p. 121
Animal Models to Study Hepatocytic Keratin Alterations	p. 122
Mallory Bodies as a Product of the Cellular Response to Misfolded Keratin	p. 124
How Can Keratins Influence Toxic Cell Injury?	p. 125
Mutations of Keratin Genes and Liver Diseases	p. 127
The Search for Specific Keratin Functions: The Case of Keratin K10	p. 131
Keratin K10 Assembly and Dynamics	p. 132
Keratin K10 Inhibits Cell Proliferation	p. 134
Transgenic Mice Models to Study K10 Functions	p. 138
The Paradigms of K10 Knock Out Model	p. 139
Reconciling Hypotheses	p. 141
Index	p. 147
Table of Contents provided by Ingram. All Rights Reserved.

Molecular Biology Intelligence Unit

At a Glance

Hardcover

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