Metallointercalators

Synthesis and Techniques to Probe Their Interactions with Biomolecules

By: Janice Aldrich-Wright (Editor)

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Hardcover | 7 April 2011

At a Glance

Hardcover
456 Pages

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23.5 x 15.88 x 3.18

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A comprehensive treatment of the characterisation techniques used in investigating inorganic and organic molecules that interact with biomolecules is presented to the reader in a clear fashion. The work consists of two parts: (i) synthetic aspects of metallointercalators along with targeting and improving transport and (ii) the various techniques that are used for probing their interactions, such as; DNA-NMR, PGSE-NMR, DNA ESI-MS, Linear and Circular Dichroism, Fluorescence Spectroscopy, Confocal Microscopy, Viscosity, TGA and dialysis, Microarrays, biological analysis. Chapters are devoted to the synthesis and the techniques used to study the interactions of inorganic complexes with biomolecules. Considerably detailed examples are used to help illustrate the application of these techniques. This book is a useful resource for an array of inorganic and organic advanced undergraduate and graduate courses and for researchers in drug discovery.

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Target Biological Structures: The Cell, Organelles, DNA and RNA	p. 1
Ruthenium Polypyridyl Metallointercalators	p. 27
The Synthesis of Platinum(n) Intercalators	p. 69
Platinum(II) Intercalating Complexes Based on 2,2':6',2"-Terpyridine	p. 101
Introduction to Nuclear Magnetic Resonance	p. 129
NMR Studies of Metallointercalator-DNA Interactions	p. 143
Pulsed Gradient Spin-Echo NMR	p. 159
Mass Spectrometric Studies of Non-Covalent Binding Interactions Between Metallointercalators and DNA	p. 187
Investigating Binding Interactions Using Linear Dichroism and Circular Dichroism	p. 215
Applications of Fluorescence Spectroscopy and Confocal Microscopy	p. 235
Synchrotron Radiation X-Ray Spectroscopy for Investigations of Intracellular Metallointercalators: X-Ray Fluorescence Imaging and X-Ray Absorption Spectroscopy	p. 273
The Use of Calorimetry to Study Ligand-DNA Interactions	p. 299
Investigating the Biological Significance of Metallointercalators with cDNA Microarrays	p. 325
Cytotoxicity Testing: Cell Experiments	p. 361
Development of Metal Complexes as Potential Antimicrobials	p. 373
Animal Testing	p. 389
Index	p. 417
Table of Contents provided by Ingram. All Rights Reserved.

Metallointercalators

Synthesis and Techniques to Probe Their Interactions with Biomolecules

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

More in Spectrum Analysis

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Chemistry for Archaeology

Heritage Sciences

Physical Chemistry Problems and Solutions

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Molecular Luminescence in Cultural Heritage

Springer Series on Fluorescence

Near Infrared Spectroscopy in Petroleum Refinery and Chemical Industry

Photoelectron Spectroscopy in Inorganic Materials Science

Inorganic Materials Series

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Inorganic Materials Series

Laser-Induced Breakdown Spectroscopy

Fundamentals and Applications

Optical and X-Ray Polarized Scattering for Porous Nanoparticles and Aggregates such as Combustion Soot

Complementary Tools for in-situ sizing and morphology evaluation of nanoclusters and fractal nanoparticles aggregates

Molecular Orientation Analysis Using Polarized Vibrational Spectroscopy

A Programmatic Approach

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Sources, Techniques, and Applications

The Nature of X-Rays and Their Interactions with Matterâ"Volume I

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Distributions, Reactions and Structures

Biological and Medical Physics, Biomedical Engineering

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