
Mathematics in Science and Engineering
Volume 206
By: Viktor V. Ivanov, Natalya V. Ivanova
Hardcover | 1 June 2006
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354 Pages
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List of abbreviations
List of notation s
Introduction: Evolutionary Systems and Development Modeli ng
Part 1: SURVE Y OF MM OF CAO
Chapter 1: General Methods of Inlet and Analysis of MM
Chapter 2: MM of Enzyme Reactions
Ch apter 3: MM of Kinetic Cellular Theory
Chapter 4: Some Othe r MM
Part 2: MM OF DEVELOPMENTSTRON G>
Chapter 5: Base MM
Chapter 6: Examples of CAO and Their MM
Ch apter 7: MM of the Cell
Chapter 8: MM of the Immune Netw ork
Chapter 9: MM of Some Other CAO
P art 3: INTRODUCTION TO APPLICATIONS
Chapte r 10: AIDS
Chapter 11: Cancers
Chapter 12 : On Life Longevity Problems
Chapter 13: On MM of a Disease
Appendix: MATHEMATICS OF DEVELOPMENT
| Preface | p. xv |
| List of abbreviations | p. xviii |
| List of notations | p. xix |
| Introduction: Evolutionary Systems and Development Modeling | p. 1 |
| Evolutionary Systems (ES) | p. 1 |
| Artificial ES | p. 1 |
| Natural ES | p. 4 |
| Joined ES | p. 6 |
| Generalized Structure of ES | p. 7 |
| Generalized Structure of Two ES Interactions | p. 8 |
| Generalized Structure of CAO | p. 10 |
| On Development Modeling | p. 12 |
| Base simplest MM of development | p. 12 |
| Comparison with classical MM | p. 14 |
| A history, in short | p. 16 |
| Survey of MM of Cao | p. 17 |
| General Methods of Inlet and Analysis of MM | p. 19 |
| Methods of Simplification of the Systems of Kinetic Equations | p. 19 |
| On the Qualitative Theory for the Systems of the Second Order | p. 21 |
| MM of cell cycles, I | p. 24 |
| MM of hyper-cycle | p. 27 |
| MM of cell excitable membranes | p. 28 |
| MM of Spatial Systems | p. 30 |
| MM of tumor angiogenesis | p. 33 |
| Mechanical models for mesenchymal morphogenesis | p. 35 |
| Possibility for Description of Biological Events on Molecular Level | p. 36 |
| MM of traffic through cell membranes | p. 39 |
| Passive transport | p. 39 |
| Active transport | p. 40 |
| On the problem of structure and protein folding | p. 41 |
| Simple kinetic MM in protein folding | p. 42 |
| Theories of reaction rates | p. 42 |
| Application to the protein folding without barriers | p. 43 |
| Physical model of DNA | p. 44 |
| MM of Enzyme Reactions | p. 47 |
| Method of Graphs | p. 47 |
| MM of Open Reactions with Substratum Inhibition | p. 49 |
| MM of Two-Substratum Reactions with Inhibition | p. 50 |
| On Multi-enzyme Systems | p. 52 |
| General notions | p. 52 |
| Simple MM of energetic metabolism | p. 53 |
| Effects of pH and T on the Reaction Rates | p. 56 |
| MM of Cell-to-Cell Interactions | p. 58 |
| MM of Kinetic Cellular Theory | p. 61 |
| Assumption 1 | p. 61 |
| Assumption 2 | p. 61 |
| Assumption 3 | p. 61 |
| Assumption 4 | p. 63 |
| Assumption 5 | p. 63 |
| Assumption 6 | p. 63 |
| Assumption 7 | p. 64 |
| Assumption 8 | p. 66 |
| Assumption 9 | p. 66 |
| Assumption 10 | p. 67 |
| Assumption 11 | p. 67 |
| On Generalized Kinetic Models in Applied Sciences | p. 68 |
| Some Other MM | p. 69 |
| Delay Differential Equations | p. 69 |
| Mathematics in Population Biology | p. 69 |
| Some Problems and MM in Computational Biology and Bioinformatics | p. 72 |
| On the Theory Catastrophes | p. 75 |
| On the Respective Software | p. 78 |
| MM of Development | p. 79 |
| Base MM | p. 81 |
| Base Minimal MM | p. 81 |
| More General MM | p. 85 |
| Additional MM | p. 88 |
| On Comparison with Well-Known MM | p. 89 |
| Methods for Estimation of MM Input Data | p. 89 |
| On the Problem of MM Completeness | p. 91 |
| Methods of CAO de- and aggregation | p. 92 |
| Detailing the CAO structure | p. 92 |
| Case of self-development of the indices [alpha]- and [beta]-types | p. 92 |
| Case of the additional "executive" subsystem (E) | p. 94 |
| Case of the additional "recreation" subsystem (R) | p. 95 |
| Further factorization of the indices [alpha]- and [beta]-types | p. 96 |
| On introduction of dimensionless relations | p. 96 |
| On using extreme concepts | p. 96 |
| Statement of the Modeling Problems | p. 98 |
| Examples of CAO and Their MM | p. 101 |
| On Hyper-Cycle, Origin of Life and DNA Code | p. 101 |
| Dehydration Synthesis and Hydrolysis | p. 103 |
| ATP Synthesis | p. 104 |
| Biosynthesis | p. 109 |
| On Pattern Formation | p. 111 |
| MM of Regulatory Processes in Cells | p. 113 |
| Biological background | p. 113 |
| Proteins turn genes on or off | p. 113 |
| Differentiated cells has a particular pattern of genes | p. 114 |
| Complex protein control transcription | p. 116 |
| RNA adds a cap and poly-A tail and removes non-coding segments | p. 116 |
| Multiple mechanisms control gene expression | p. 117 |
| Gene expression and cell-to-cell signaling | p. 119 |
| Signal-transduction pathways | p. 119 |
| MM of turning genes on or off | p. 120 |
| MM of DNA transcription and mRNA translation | p. 122 |
| MM of signal-transduction pathways | p. 122 |
| MM of molecular pumps | p. 123 |
| MM of the Cell | p. 125 |
| On Cell Biology | p. 125 |
| Molecular constituents of cells | p. 125 |
| Structure and functions of cells | p. 127 |
| On cell metabolism | p. 131 |
| On control of gene expression | p. 132 |
| Summing up | p. 133 |
| Base MM of a Cell | p. 134 |
| MM of cell structure and functions | p. 135 |
| MM of a cell with regard to its given spatial structure | p. 136 |
| MM of developing cell | p. 137 |
| MM of cell bio-field | p. 139 |
| On the Protein Folding Problem | p. 140 |
| MM of Cell Cycle, II | p. 142 |
| Biological background | p. 142 |
| The respective MM | p. 145 |
| MM of Morphogenesis | p. 146 |
| Biological background | p. 146 |
| The respective MM | p. 149 |
| MM of the Immune Network | p. 151 |
| Introduction | p. 151 |
| Cells of the Immune System | p. 152 |
| On the immune system | p. 152 |
| Properties of the immune network cells | p. 154 |
| Continuous MM | p. 157 |
| On the Classical and the New Approach | p. 163 |
| Some Results of Investigation | p. 166 |
| Conclusion | p. 167 |
| MM of Some Other CAO | p. 169 |
| Function of Special Cells | p. 169 |
| MM of Stem Cells | p. 170 |
| MM of Thymus and Spleen | p. 172 |
| MM of the Immune and Blood System Cells | p. 173 |
| MM of Endothelial Cells | p. 175 |
| Conclusion | p. 175 |
| Introduction to Applications | p. 177 |
| AIDS | p. 179 |
| Introduction | p. 179 |
| Immune Status of an Organism | p. 179 |
| Viruses | p. 181 |
| Main properties of viruses | p. 181 |
| On retroviruses and HIV | p. 181 |
| Pattern of HIV infection | p. 183 |
| MM of Viruses | p. 183 |
| Base MM | p. 183 |
| MM of HIV | p. 184 |
| Qualitative investigation of MM of HIV | p. 185 |
| More complicated MM of HIV and its qualitative investigation | p. 188 |
| MM of HIV population | p. 189 |
| MM of HIV population inside of the host cell | p. 189 |
| MM of HIV free population | p. 190 |
| MM of AIDS | p. 192 |
| Qualitative investigation of MM of AIDS | p. 196 |
| On AIDS immune therapy | p. 198 |
| Conclusion | p. 200 |
| Cancers | p. 201 |
| On Study of a Cancer at the Molecular Level | p. 201 |
| MM of a Cancer Cell | p. 203 |
| Base MM of a cell at the start of proliferation | p. 203 |
| More complicated MM | p. 204 |
| MM of developing daughter cell | p. 206 |
| MM of a cancer cell bio-field | p. 207 |
| Qualitative Investigation of MM of a Cancer Cell | p. 208 |
| Investigation of MM (1)-(5) | p. 208 |
| Investigation of MM (6)-(8) | p. 210 |
| Investigation of MM (9), (10) | p. 212 |
| MM of a Cancer | p. 213 |
| Base MM of interaction of a cancer with host organism | p. 216 |
| Qualitative investigation of MM of a cancer | p. 217 |
| Investigation of MM (37)-(43) | p. 217 |
| Investigation of MM (44), (45) | p. 221 |
| On Immune Therapy of Cancers | p. 224 |
| On Gene Therapy of Cancers | p. 225 |
| Conclusion | p. 227 |
| On Life Longevity Problems | p. 229 |
| Clock of Cellular Aging | p. 229 |
| Error accumulation theory | p. 229 |
| Programmed dearth theory | p. 229 |
| Winding back the clock | p. 230 |
| Modeling of Cell Longevity Problems | p. 231 |
| Modeling of error accumulation | p. 231 |
| Modeling of programmed death | p. 232 |
| Modeling of winding back the clock | p. 233 |
| On Modeling of Organism Longevity Problems | p. 234 |
| Certain Perspectives | p. 235 |
| On MM of a Disease | p. 237 |
| Introduction | p. 237 |
| Conception of the Norm and Pathology | p. 238 |
| Norm Restoration Problems | p. 239 |
| On Optimization Problems | p. 240 |
| On the Problems of Individualization of MM | p. 241 |
| On MM of Doctor's Business | p. 242 |
| Mathematics of Development | p. 245 |
| Investigation of Equations | p. 247 |
| Examples of Analytic Solutions | p. 247 |
| Existence and Uniqueness of Solutions | p. 249 |
| Cases of Non-Uniqueness of Solutions | p. 259 |
| On Stability of Solutions | p. 260 |
| Cases of Oscillating, Wave, and Some Other Solutions | p. 262 |
| Asymptotic Properties of Solutions | p. 266 |
| Some Additions and Remarks | p. 267 |
| Investigation of Optimization Problems | p. 269 |
| Preliminary Concepts and Results | p. 269 |
| Examples of Analytical Solutions | p. 274 |
| Existence and Uniqueness of Solutions | p. 276 |
| On Stability of Solutions | p. 280 |
| On Investigation of Solution Structure | p. 283 |
| Case of Non-Uniqueness of Solutions | p. 286 |
| Asymptotic Properties of Solutions | p. 288 |
| Additions and Remarks | p. 290 |
| Numerical Methods and Software | p. 293 |
| On the Solution with the Pre-Assigned Accuracy | p. 293 |
| Second kind of Volterra equations | p. 293 |
| Inherent errors | p. 293 |
| Method errors | p. 297 |
| Round-off errors | p. 302 |
| Analysis of the total errors | p. 303 |
| First kind of Volterra equations | p. 304 |
| Two main approaches | p. 304 |
| Quasi-solution method | p. 305 |
| Estimate of continuity modules for reciprocal operators | p. 306 |
| On regularization for linear equations | p. 307 |
| Reduction to Volterra-Type Equations | p. 309 |
| Mathematical programming problems | p. 309 |
| Some other problems | p. 312 |
| On Optimal Numerical Methods | p. 313 |
| Approximation of functions | p. 313 |
| On the solution of other applied problems | p. 314 |
| On Algorithms and Software | p. 317 |
| Summary | p. 319 |
| Bibliography | p. 321 |
| Index | p. 329 |
| About the Authors | p. 333 |
| Table of Contents provided by Ingram. All Rights Reserved. |
ISBN: 9780444527141
ISBN-10: 0444527141
Series: Mathematics in Science and Engineering
Published: 1st June 2006
Format: Hardcover
Language: English
Number of Pages: 354
Audience: General Adult
Publisher: ELSEVIER SCIENCE & TECHNOLOGY
Country of Publication: GB
Dimensions (cm): 22.86 x 1.27 x 3.86
Weight (kg): 0.68
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