Advances in Experimental Medicine and Biology

- Part A.- Tissue Kallikreins and Kinins: Roles in Human Disease and Target for New Drug Development.- Control of Kininogen Gene Expression.- Angiotensin I Converting Enzyme Inhibitors, Kinin and Prostaglandin Systems.- Biochemistry of Renin.- Angiotensin I Converting Enzyme.- Pharmocokinetics of Angiotensin Converting Enzyme Inhibitors in Plasma and Tissue Using Radioinhibitor Binding and Displacement Assays.- Role of the Endogenous Angiotensin II in the Antihypertensive Effect of MK 421 in Rats Made Hypertensive by Norepinephrine or Vasopressin.- Significance of Kallikrein-Kinin and Renin-Angiotensin Systems in the Hypotensive Mechanism of Angiotensin-I Converting Enzyme Inhibitors in Essential Hypertensives.- Clinical Usefulness of Low-Dose Captopril on Mild to Moderate Essential Hypertension.- Therapeutic Regime of Enalapril Maleate in Japan.- Beneficial and Adverse Effects of Angiotensin Converting Enzyme Inhibitors.- Tissue Kallikrein and its Functional Roles - Kidney and Other Organs -.- Structural Analysis of a Rat Renal Kallikrein Gene.- Development of Competitive Antagonists of Bradykinin.- Physiological Role of Renal Kallikrein-Kinin System in Human.- Effects of Kinin on Electrolytes Transport and Regulation of Kininase Activity in Distal Nephron Segments of the Rat.- Diversity of Kinin Effects on Transporting Epithelia.- Patho-Physiology of Kallikrein-Kinin System - Inflammation, Allergy and Others -.- The Role of T-Kininogen and H and L Kininogens in Health and Disease.- Recent Studies on the Role of Kinins in Inflammatory Diseases of Human Airways.- The Kallikrein-Kinin System in Inflammation.- A Significant Role of Plasma Kallikrein-Kinin System in Plasma Exudation of Rat Carrageenin-Induced Pleurisy.- Role of High Molecular Weight (HMW)-Kininogen in Inflammatory Exudation: Evidence with the Studies of the HMW-Kininogen Deficient Rat.- Kallikrein-Kinin System in Infectious Diseases.- Kininogen in Tumor-Bearing Mice.- Angiotensin Converting Enzyme and Inhibitors.- Regional Distribution of Angiotensin Converting Enzyme in the Rat Kidney.- Immunohistologic Characterization of Angiotensin Converting Enzyme in the Human Kidney Using Monoclonal and Polyclonal Antibodies.- Effects of Mineralocorticoid on Kininase Activity Along the Distal Nephron Segments of the Rat.- Selective Expression of Des-Arg9-BK Sensitive (B1) Receptors In Vivo and In Vitro by Angiotensin Converting Enzyme Inhibitors.- Demonstration of In Vivo Effects of Ace Inhibitors by the Use of Autoregressive Modelling.- Contribution of Kinin System to the Antihypertensive Action of Angiotensin Converting Enzyme Inhibitors.- Increased Insulin-Responsiveness by Ace-Inhibition in Non-Insulin Dependent Diabetes Mellitus.- Kinins, Related Peptides and Arachidonic Acid Metabolites.- A New Structural Class of Biologically Active Peptide in Non-Mammals.- Vasoactive Peptides from the VESPA Orientalis Hornet Venom.- Bradykinin Analogs Induce Histamine Release from Human Skin Mast Cells.- Role of Cardiovascular Phospholipase A2 and C in the Development of DOCA-Salt Hypertensive Rats.- Neutrophil Producing Capacity of 5-Lipoxygenase Metabolites of Arachidonic Acid After Major Surgery.- The Mechanism of the Stimulatory Effect of Kallikrein on Prostacyclin Production in Vascular Endothelial Cells.- The Effect of Bradykinin and its Fragments on the Arachidonate Cascade of Brain Microvessels.- Mechanism of Bradykinin-Induced Nociceptive Response.- Antagonism of the Algesic Action of Bradykinin on the Human Blister Base.- Kallikrein-Kinin in Renal Function.- Effects of Sodium Intake on Urinary Excretion and Renal Content of Bradykinin and its Metabolites in Rats.- Kallikrein Release by Rat Kidney Slices: Effect of Norepinephrine.- Relationship Between ANP, Cyclic GMP and Tissue Kallikrein Following Saline Infusion in Healthy Volunteers.- Bradykinin (BK) Enhances Diuresis and Natriuresis in Saline Volume-Expanded Dogs.- Kininases.- Kininase Activities in the Human Pituitary Gland.- Purification of Human Seminal Plasma Kininase II Using Affinity Chromatography.- Dipeptidyl(Amino)Peptidase IV and Post Proline Cleaving Enzyme in Cultured Endothelial and Smooth Muscle Cells.- Isolation and Study of the Properties of Kininase from the Venom of Spider Latrodectus Tredecimguttatus.- Post Synthetic Modification of CK-MM by Kininase I.- Structure of Human Carboxypeptidase in (Kininase I).- The Mechanism of Degradation of Bradykinin (LYSYL-Bradykinin) in Human Serum.- Kininogens.- Rocket Immunoassay of High and Low Molecular Weight Kininogens in Human Plasma.- High Molecular Weight Kininogen Binds to Neutrophils.- Inhibition of Thrombin-Induced Platelet Aggregation by High Molecular Weight Kininogen.- Characterization of Kinins Released from Human Kininogens by Human Urinary Kallikrein.- Ornitho-kininogen and Ornitho-kinin: Isolation, Characterization, and Chemical Structure.- Inflammation and Kallikrein-Kinin.- The Kallikrein-Kininogen System in Myocardial Infarction.- The Pathophysiological Role of Kinin and Chemical Mediators on Experimental Allergic Rhinitis.- Release of Kinin and Other Chemical Mediators After Antigenic Stimulation in Allergic Rhinitis Patients.- Akikatsu Kataura, Kazuaki Shimamoto, and Osamu Iimura Kallikrein Activity in Saliva of Patients with Inflammatory and Hyperplastic Diseases of the Oral Mucous Membrane.- The Effect of Cyclosporine on Urinary Kallikrein Excretion in Patients with Rheumatoid Arthritis.- The Influence of Oxindanac on Kallikrein Metabolism.- Kinin Receptors and Antagonists.- Basic Pharmacology of Kinis: Pharmacologic Receptors and Other Mechanisms.- An Iodinatable Photoaffinity Probe Based on the Structure of Kallidin.- Specific Binding Sites for Bradykinin and its Degradation Process in Cultured Rat Vascular Smooth Muscle Cells.- Kinin Receptors on Epithelial Cells and Smooth Muscle of the Trachea.- Different Involvement of Endothelium-Derived Relaxing Factor and Prostacyclin in Vasodilator Response to Bradykinin in Isolated Dog Blood Vessels.- The Effect of a Bradykinin Antagonist on Vasodilatation in the Cat and Rabbit.- Effects on Blood Pressure of Intracerebroventricular Administration of a Kinin Antagonist.- Plasma Kallikrein-Kinin and Related Systems.- Hageman Factor Dependent Kinin Generation System in Guinea Pig Skin: Extravascular Localization of the Components, and Prolonged Vascular Reaction in Inhibitor-Depleted Animal of This System.- Hageman Factor Activation by Polysaccharides: Effect of Molecular Weight.- Some Cardiovascular and Hematological Changes Induced in the Rat by Activation of Hageman Factor with Ellagic Acid.- Isolation and Characterization of Plant Inhibitors Directed Against Plasma Kallikrein and Factor XII.- A Monoclonal Antibody Recognizing an Iscosapeptide Sequence in the Heavy Chain of Human Factor XII Inhibits Surface-Catalyzed Activation.- Effects of INtravascular Ionic and Non-Ionic Radiographic Contrast Agents on Parameters of the Kallikrein-Kinin-System.- Changes in Components of the KK-System After Recirculation and the Addition of Plasma Kallikrein.- Degradation of Hageman Factor by Chymotrypsin-Like Protease Released from Rat Mast Cells During Degranulation.- Kinin Release from Human LMW-Kininogen by the Cooperative Action of Human Plasma Kallikrein and Leukocyte Elastase.- Binding of a Monoclonal Anti-Human Plasma Prekalliprein Antibody to the Complexes of Kallikrein with Cl-Inhibitor and ?2-Macroglobulin Analyzed by Immunoblot and "Sandwich" Assays.- Tissue Kallikreins.- Human Urinary Kallikreins A, B, and D: Isolation, Purification, and Properties.- Human Urinary Prokallikrein - Structural Analysis on Activation Mechanism.- Human Urinary Kallikrein: Amino Acid Sequence and Carbohydrate Attachment Sites.- Structural Analysis of ASN-Linked Oligosaccharides of Porcine Pancreatic Kallikrein.- Fast Atom Bombardment Mass Spectrometry (FAB-MS): Analysis of Complex Carbohydrate Chains of Tissue Kallikreins.- Isolation of [Hydroxyproline3]Lysyl-Bradykinin Formed I by Kallikrein From Human Plasma Protein.- Tissue Kallikrein Effectively Activates Latent Matrix Degrading Metalloenzymes.- A Micro-Kininogenase Assay for Studies of Kallikrein in Renal Micropuncture/Microperfusion.- Exercise-Induced Increase in Glandular Kallikrein Activity In Human Plasma and Its Significance in Peripheral Glucose Metabolism.- Kallikrein-Induced Rat Uterus Contraction is Dependent On I Kinin Release.- Relationship Between Human Seminal Kallikrein-Kinin System and Spermatogenesis.- Tonin and Kallikrein-Kinin System.- Kallikrein-Kinin in Health and Diseases.- Bradykinin Infusion in Long Term Postoperative Parenteral Nutrition Improves Nitrogen Balance and Protein Synthesis.- Quantification, Isolation, and Structural Determination of Bradykinin and Hydroxyprolyl-Bradykinin in Tumor Ascites.- Studies on Kallikrein-Kinin System and Enzymes Activity in Organs and Urine from Diabetic Mice Models.- Serum Kininases I and II in Patients with Extrinsic and Intrinsic Asthma.- Dose-Dependent Effects of Bradykinin Infusion in Post-Operative Patients.- Evidence for Multiple Functions of T-Lymphocytes Associated Serine Proteinases.- Components of the Plasma Defense Systems in Intensive Care Patients With and Without ARDS.- Interrelationship Between Urinary Kallikrein and Arginine-Vasopressin in Man.- Natriuresis and Kallikrein-Kinin.- Attenuation of Atrial Natriuretic Peptide by Kallikrein in Taurine Administered Rats.- Mechanism of Taurine Natriuresis in Rats.- Interaction of Atrial Natriuretic Peptide and Amiloride on the Renal Kallikrein-Kinin System.- Opposite Effects on Kallikrein Excretion of Natriuretic Doses of Angiotensin Infused into the Dog and the Rat: Reversal of the Effect in the Rat by Atrial Natriuretic Peptide.