IGFs

Local Repair and Survival Factors Throughout Life Span

By: David Clemmons (Editor), Iain C.A.F. Robinson (Editor)

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Hardcover | 3 December 2009

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172 Pages

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23.5 x 15.24 x 0.64

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Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.

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GH & IGFI: Aspects of Global and Local Release and Actions	p. 1
Hyperglycemia Regulates the Sensitivity of Vascular Cells to IGF-I Stimulation	p. 11
IGFBP2 Supports ex Vivo Expension of Hematopoietic Stem Cells	p. 21
The Role of Insulin-like Growth Factor-I in Central Nervous System Development	p. 43
Stimulation of Proliferative Pathways by IGF-binding Proteins	p. 59
Signaling Pathways that Regulate C. elegans Life Span	p. 69
IGFI Regulation of Skeletal Muscle Hypertrophy and Atrophy	p. 85
Growth Hormone, Insulin-like Growth Factor I and Insulin: their Relationship to Aging and Cancer	p. 97
The Functions of Insulin-like Peptides in Insects	p. 105
IGF Receptors in the Adult Brain	p. 125
The Role of the IGF-1 and Partners in Central and Peripheral Metabolism: Considerations for Extending Healthy Life Span	p. 143
Index	p. 155
Table of Contents provided by Ingram. All Rights Reserved.

IGFs

Local Repair and Survival Factors Throughout Life Span

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

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