Human Experimentation : Methodologic Issues Fundamental to Clinical Trials - Ton J. Cleophas

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Human Experimentation

Methodologic Issues Fundamental to Clinical Trials

By: Ton J. Cleophas

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Paperback | 31 July 1999

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120 Pages

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Despite their effectiveness in the evaluation of new pharmacological compounds, controlled clinical trials are sometimes inadequate. Using data from the literature as well as from the author's own experience with clinical trials, Human Experimentation: Methodologic Issues Fundamental to Clinical Trials addresses such inadequacies and tries to provide solutions. This work is the first to thoroughly examine these unsolved inadequacies and problems with the design and the execution of clinical trials and, more importantly, to provide solutions for these problems. It is important for anyone who is involved in clinical research: clinicians, pharmacists, biochemists, statisticians, nurses, sponsors, etc., and anyone who is involved in applying results of research to patients, i.e. physicians.

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You Can Find This Book In

Non-Fiction Medicine Clinical & Internal Medicine Medicine in General Medical Profession Medical Ethics & Professional Conduct Society & Culture Ethical Issues & Debates Ethical Issues of Scientific & Technological Developments Other Branches of Medicine Pharmacology Medical Equipment & Techniques

Medical Research Nursing & Ancillary Services Pharmacy & Dispensing Public Health & Preventive Medicine Epidemiology & Medical Statistics Mathematics Probability & Statistics

Foreword
Preface
Placebos	p. 1
Fundamental Issues of Choosing the Right Type of Trial	p. 7
Lack of Real Science of Symptom-Based Care	p. 15
Carryover Effects in Clinical Research	p. 25
Criticism of Negative Studies Due to Negative Correlations	p. 37
Between-Group Disparities in Drug Response	p. 48
Specific Problems with Trials of Chronic Diseases	p. 57
Clinical Trials with New Endpoints	p. 66
Linear Scale Assessment of Relevant Domains of Quality of Life - an example	p. 73
Item Response Modeling and Quality of Life	p. 81
Is Selective Reporting of Well-Designed Research Unethical as Well as Unscientific?	p. 90
Informed Consent Under Scrutiny, Suggestions for Improvement	p. 99
Table of Contents provided by Blackwell. All Rights Reserved.

Human Experimentation

Methodologic Issues Fundamental to Clinical Trials

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Paperback

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