Genome-Scale Algorithm Design

Bioinformatics in the Era of High-Throughput Sequencing

By: Veli MÃ¤kinen, Djamal Belazzougui, Fabio Cunial, Alexandru I. Tomescu

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Hardcover | 12 October 2023 | Edition Number 2

At a Glance

Hardcover
487 Pages

Edition Type
Revised

Dimensions(cm)
17.7 x 25.3 x 3.3

Hardcover

RRP $109.95

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Presenting the fundamental algorithms and data structures that power bioinformatics workflows, this book covers a range of topics from the foundations of sequence analysis (alignments and hidden Markov models) to classical index structures (k-mer indexes, suffix arrays, and suffix trees), Burrowsâ"Wheeler indexes, graph algorithms, network flows, and a number of advanced omics applications. The chapters feature numerous examples, algorithm visualizations, and exercises, providing graduate students, researchers, and practitioners with a powerful algorithmic toolkit for the applications of high-throughput sequencing. An accompanying website (www.genome-scale.info) offers supporting teaching material. The second edition strengthens the toolkit by covering minimizers and other advanced data structures and their use in emerging pangenomics approaches.

Industry Reviews

'This book is very effective in addressing its intended target of graduate students in bioinformatics or computer science with a well-structured but highly accessible description of the fundamental algorithms and data structures that power standard sequence analysis workflows.' Romeo Rizzi, University of Verona

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