Fundamental Problems

I. The natural history and clinical significance of breast cancer detected by imaging techniques.- 1. Pathology of breast cancer detected by imaging techniques.- 2. Screening for breast cancer: an overview.- 3. Research in new imaging methods for detection of breast cancer.- 4. The Canadian national breast screening study: current status.- 5. Natural history of mammary tumors seen in a breast center.- 6. An educational and diagnostic breast center in edmonton: a preliminary report of the first year.- 7. The Breast Center-a multidisciplinary model.- 8. Multimodality breast imaging: the value of diaphanography.- 9. Comparative value of diaphanoscopy, mammography, and thermography for breast cancer screening.- 10. Finding earlier nonpalpable breast cancers using hooked wire directed biopsy and a modified overpenetrated mammographic technique.- 11. The significance of tumor size in stage I invasive breast cancer.- 12. The impact of breast cancer screening on surgical treatment policies.- 13. Survival of patients with breast cancer detected between mammographic screenings.- 14. Intraductal breast carcinoma-what constitutes adequate treatment?.- II. Aspects of the growth and mechanism of response of endocrine sensitive breast cancer.- 15. Endocrine and other influences in the normal development of the breast.- 16. Endocrine prevention of breast cancer by tamoxifen.- 17. Mechanisms of regression and revised approaches to endocrine therapy.- 18. Growth factors, oncogenes, and breast cancer.- 19. Estrogenic recruitment followed by chemotherapy in breast cancer: experimental and clinical results.- 20. Relationship of breast cancer hormone receptors, menopausal status, and adjuvant therapy to site(s) of recurrence and survival.- 21. Cyclical use of tamoxifen and high-dose medroxyprogesterone acetate in advanced breast cancer.- 22. An inverse relationship between intracellular prolactin and growth hormone and estrogen receptor status in human breast cancers.- 23. Steroid receptors in breast cancer: Kuwait experience.- III. Adjuvant systemic therapy: current clinical trials and aspects of statistical evaluation of adjuvant chemotherapy.- 24. Breast cancer trials of the Ludwig and International Breast Cancer Study Group.- 25. The validity of summing results of clinical trials in breast cancer.- 26. Cost-benefit analysis of chemotherapy trials.- 27. Adjuvant therapy in postmenopausal patients with operable breast cancer.- IV. Research on life quality and the effect of local and systemic therapy on quality of life.- 28. Autonomic insufficiency in patients with advanced breast cancer.- 29. Brachial plexopathy in patients with breast cancer.- 30. Lymphedema-its treatment.- 31. Competing causes of death in breast cancer patients.- 32. Breast cancer profile in India: experiences at the Tata Memorial Hospital, Bombay.- V. Laboratory research relevant to the management of patients with breast cancer over the next decade.- 33. Tumor metastasis: biology and experimental therapeutic approaches.- 34. The detection and evaluation of bone marrow micrometastases in primary breast cancer.- 35. Physiology of bone and metabolic approaches to the treatment of skeletal metastases.- 36. Expression of the ras oncogene p21 protein in human breast tumors and in several benign conditions using the y13 259 monoclonal antibody.- 37. Synergistic effect of cell kinetics-directed chemo-endocrine therapy on experimental mammary tumors.- VI. Future directions in the assessment, management, and treatment of the patient with breast cancer.- 38. The natural history of human breast cancer: implications for patient management.- 39. Assessment of treatment in the clinic.- 40. Treatment of metastatic breast cancer as a guide to design of adjuvant therapy trials.- 41. Problems associated with the assessment of patients with metastatic breast cancer: can past experience teach us to do better clinical trials?.- 42. Preoperative combined modality (neoadjuvant) therapy for locally advanced inoperable breast cancer (LAIBC).- 43. Priorities in cancer control strategies in India.- 44. The epidemiology of breast cancer from an African perspective.- Summary: breast cancer in the eighties.