Farming Human Pathogens

Ecological Resilience and Evolutionary Process

By: Rodrick Wallace, Deborah Wallace, Robert G. Wallace

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Hardcover | 18 May 2009

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228 Pages

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24.13 x 16.51 x 1.27

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Farming Human Pathogens: Ecological Resilience and Evolutionary Process introduces a cutting-edge mathematical formalism based on the asymptotic limit theorems of information theory to describe how punctuated shifts in mesoscale ecosystems can entrain patterns of gene expression and organismal evolution. The authors apply the new formalism toward characterizing a number of infectious diseases that have evolved in response to the world as humans have made it. Many of the human pathogens that are emerging out from underneath epidemiological control are 'farmed' in the metaphorical sense, as the evolution of drug-resistant HIV makes clear, but also quite literally, as demonstrated by avian influenza's emergence from poultry farms in southern China. The most successful pathogens appear able to integrate selection pressures humans have imposed upon them from a variety of socioecological scales. The book also presents a related treatment of Eigen's Paradox and the RNA 'error catastrophe' that bedevils models of the origins of viruses and of biological life itself.

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Introduction	p. 1
Ecosystems as information sources	p. 3
Coarse-graining a simple model	p. 3
Ecosystems and information	p. 5
Cognition as an information source	p. 8
Immune cognition	p. 12
Tumor control	p. 14
A cognitive paradigm for gene expression	p. 14
Darwinian genetic inheritance as an information source	p. 18
Formal theory I	p. 21
The cognitive modular network symmetry groupoid	p. 21
Global and local symmetry groupoids	p. 23
Internal forces breaking the symmetry groupoid	p. 25
External forces breaking the symmetry groupoid	p. 27
Emergence in information systems as a phase transition	p. 28
Multiple workspaces: topological tuning	p. 29
Phenomenological Landau theory	p. 32
The dynamical groupoid: Phenomenological Onsager theory	p. 34
Tuning the network of dynamic manifolds	p. 41
The rate distortion manifold	p. 41
No free lunch	p. 48
Mesoscale resonance: Many Baldwin effects	p. 50
Directed homotopy	p. 51
Pathologies of gene expression	p. 54
Traveling waves on cognitive modular networks	p. 57
Formal theory II	p. 63
The mean field model	p. 63
Biological renormalization	p. 66
Universality class distribution	p. 71
Punctuated universality class tuning	p. 72
Another network of dynamic manifolds and its tuning	p. 75
Evolutionary implications of multiple models	p. 75
Coevolution	p. 77
The basic idea	p. 77
Fragmentation and coalescence	p. 77
Recursive interaction	p. 83
Extending the model	p. 86
The large deviations formalism	p. 89
Farming a coevolutionary system	p. 94
Eigen's paradox	p. 97
Introduction	p. 97
Reconsidering the Eigen model	p. 99
Capacity of a parallel channel	p. 102
Rate distortion dynamics	p. 102
Rate distortion coevolution	p. 105
Farming human pathogens	p. 109
Culture and the infection phenotype: a modeling exercise	p. 109
Introduction	p. 110
Universality class tuning	p. 112
The adaptive mutator	p. 114
Population stress and pathogen response	p. 115
The phenotype coevolution ratchet	p. 117
Implications of the model	p. 118
Culture and the infection phenotype: case histories	p. 121
Introduction	p. 121
Genes, cognition, and culture	p. 122
Immune cognition and culture	p. 123
Malaria and the Fulani	p. 124
'Heterosexual AIDS' in Northern New Jersey	p. 127
Conclusions and speculations	p. 129
Multiple Drug Resistant HIV in New York	p. 131
Introduction	p. 131
Evolutionary biology of HIV	p. 135
Hierarchical diffusion	p. 137
Avian influenza	p. 141
Panic in the city	p. 141
Farming deadly influenza	p. 143
The political virology of offshore farming	p. 145
Why Guangdong? Why 1997?	p. 149
700 million chickens	p. 151
Asian financial flu	p. 155
Layers of complication	p. 157
The political will for an epidemiological way?	p. 159
Final Remarks	p. 163
Mathematical Appendix I	p. 169
The Shannon-McMillan Theorem	p. 169
The Rate Distortion Theorem	p. 171
Morse Theory	p. 174
Geodesic flows	p. 176
Mathematical Appendix II	p. 181
Martingales	p. 181
Nested Martingales	p. 183
The Martingale Transform	p. 184
Stochastic Differential Equations	p. 185
References	p. 191
Index	p. 215
Table of Contents provided by Ingram. All Rights Reserved.

Farming Human Pathogens

Ecological Resilience and Evolutionary Process

At a Glance

Hardcover

Shipping

How to return your order

Defective items

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