Epigenetics

Development and Disease

By: Tapas K. Kundu (Editor)

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Hardcover | 13 November 2012

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716 Pages

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Epigenetics is the phenomenon which fine tunes the processes associated with life, beyond that which is specified by the sequence of the genetic material; DNA. The covalent modification of DNA, DNA associated histones, several non histone proteins as well as non coding RNA coherently operate to establish the epigenetic regulation of gene expression in physiological and pathophysiological conditions. This volume presents contributions from worldwide experts presenting their research and findings, including: the evolution of epigenetic machineries from archaea to higher eukaryotes; role of epigenetics in development and transcription regulation; epigenetic landscape of human disease; a chemical biology approach to understanding epigenetic phenomena; exploration of different small molecules as epigenetic therapies. This volume is aimed at students and researchers of chromatin biology and epigenetics and will also be of interest to a broader pharmaceutical audience.

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Epigenetics and Evolution
Chromatin Organization, Epigenetics and Differentiation: An Evolutionary Perspective	p. 3
Secondary Structures of the Core Histone N-tenninal Tails: Their Role in Regulating Chromatin Structure	p. 37
Megabase Replication Domains Along the Human Genome: Relation to Chromatin Structure and Genome Organisation	p. 57
Role of DNA Methyltransferases in Epigenetic Regulation in Bacteria	p. 81
Developmental Epigenetics
Metabolic Aspects of Epigenome: Coupling of S-Adenosylmethionine Synthesis and Gene Regulation on Chromatin by SAMIT Module	p. 105
Epigenetic Regulation of Male Germ Cell Differentiation	p. 119
Epigenetic Regulation of Skeletal Muscle Development and Differentiation	p. 139
Small Changes, Big Effects: Chromatin Goes Aging	p. 151
Homeotic Gene Regulation: A Paradigm for Epigenetic Mechanisms Underlying Organismal Development	p. 177
Epigenetics and Transcription Regulation
Basic Mechanisms in RNA Polymerase I Transcription of the Ribosomal RNA 0Genes	p. 211
The RNA Polymerase II Transcriptional Machinery and Its Epigenetic Context	p. 237
RNA Polymerase III Transcription - Regulated by Chromatin Structure and Regulator of Nuclear Chromatin Organization	p. 261
The Role of DNA Methylation and Histone Modifications in Transcriptional Regulation in Humans	p. 289
Histone Variants and Transcription Regulation	p. 319
Noncoding RNAs in Chromatin Organization and Transcription Regulation: An Epigenetic View	p. 343
Chromatin Structure and Organization: The Relation with Gene Expression During Development and Disease	p. 373
Epigenetics and Disease
Cancer: An Epigenetic Landscape	p. 399
Epigenetic Regulation of Cancer Stem Cell Gene Expression	p. 419
Role of Epigenetic Mechanisms in the Vascular Complications of Diabetes	p. 435
Epigenetic Changes in Inflammatory, and Autoimmune Diseases	p. 455
Epigenetic Regulation of HTV-1 Persistence and Evolving Strategies for Virus Eradication	p. 479
Epigenetics in Parkinson's and Alzheimer's Diseases	p. 507
Cellular Redox, Epigenetics and Diseases	p. 527
Understanding of Epigenetics: A Chemical Biology Approach and Epigenetic Therapy
Stem Cell Plasticity in Development and Cancer: Epigenetic Origin of Cancer Stem Cells	p. 545
Histone Acetylation as a Therapeutic Target	p. 567
DNA Methylation and Cancer	p. 597
Role of Epigenetics in Inflammation-Associated Diseases	p. 627
Plasmodium falciparum: Epigenetic Control of var Gene Regulation and Disease	p. 659
Index	p. 683
Table of Contents provided by Ingram. All Rights Reserved.

Epigenetics

Development and Disease

At a Glance

Hardcover

Shipping

How to return your order

Defective items

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