Ectoparasites

List of Contributors VII

Foreword XIII

Preface XV

Part One Strategies & Resistance 1

1 Comparison of Antiâectoparasite and Antiâendoparasite Therapies and Control Strategies 3
Debra J. Woods*, Tom L. McTier, and Andrew A. DeRosa

2 vaccination Against Ticks 25
Theo P.M. Schetters*

3 Blocking Transmission of vectorâborne Diseases  43
Sandra SchorderetâWeber, Sandra Noack, Paul M. Selzer, and Ronald Kaminsky*

4 The Threat and Reality of Drug Resistance in the Cattle Tick Rhipicephalus (Boophilus) microplus  95
Heinz Sager*, L©onore Lovis, Christian Epe, and Ronald Kaminsky

5 Monitoring Drug Sensitivity in Cattle Ticks 109
Leonore Lovis, Christian Epe, Ronald Kaminsky, and Heinz Sager*

6 New Developments in the Control of Human Lice 119
John M. Clark*

Part Two Screens & Models 139

7 Molecular Targets to Impair Blood Meal Processing in Ticks 141
Petr Kop¡Äek*, Jan Perner, Daniel Sojka, Radek Å ­ma, and OndÅej HajduÅ¡ek

8 Wholeâorganism Screens for Ectoparasites 167
Jeffrey N. Clark* and Cedric J. Pearce

9 In vitro Feeding Methods for Hematophagous Arthropods and Their Application in Drug Discovery 187
Ard M. Nijhof* and Katharine R. Tyson

10 Testing in Laboratory Animal Models for Ectoparasiticide Discovery and Development 205
Sandra SchorderetâWeber* and Ronald Kaminsky

11 Testing in Target Hosts for Ectoparasiticide Discovery and Development 223
Jeffrey N. Clark*

Part Three Isoxazolines 243

12 Isoxazolines: A Novel Chemotype Highly Effective on Ectoparasites 245
Tina Weber and Paul M. Selzer*

13 The Discovery of Afoxolaner: A New Ectoparasiticide for Dogs  259
Ming Xu, Jeffrey K. Long, George P. Lahm*, Wesley L. Shoop, Daniel Cordova, Ty Wagerle, Ben K. Smith, Thomas F. Pahutski, Rafael Shapiro, Michael Mahaffey, Eric J. Hartline, Brandon R. Gould, Molly E. Waddell, Richard G. McDowell, John B. Kinney, Gail S. Jones, Robert F. Dietrich, Mark E. Schroeder, Daniel F. Rhoades, Eric A. Benner, and Pat N. Confalone

14 Development of Afoxolaner as a New Ectoparasiticide for Dogs 273
Laura Letendre*, Diane Larsen, and Mark Soll

15 Discovery, Development, and Commercialization of Sarolaner (Simparica®), A Novel Oral Isoxazoline Ectoparasiticide for Dogs 295
Debra J. Woods* and Tom L. McTier

16 Isoxazolines: Preeminent Ectoparasiticides of the Early Twentyâfirst Century 319
Alan Long*

Index 353