Conquering RAS

SECTION I: RAS CANCER BIOLOGY 1. Ras and RASSF effector proteins / Jessica N. Mezzanotte and Geoffrey J. Clark 2. Ras and the Hippo pathway in cancer / Eric O'Neill 3. The Many Roles of RalGTPases in Ras-driven Cancer / David F. Kashatus 4. The biology, prognostic relevance and targeted treatment of Ras pathway positive childhood acute lymphoblastic leukemia / Julie Anne Elizabeth Irving 5. Oncogenic KRAS and the Inflammatory Microenvironment in Pancreatic Cancer / Hui-Hua Chang, Andrea Schmidt and Guido Eibl 6. Activation of Ras by Post-Translational Modifications / Shengyan Xiang, Wenlong Bai, Gerold Bepler and Xiaohong Zhang 7. Cross talk between Snail and mutant K-ras contributes to pancreatic cancer progression / Christina R. Chow, Kazumi Ebine, Holly Z. Hattaway, Krishan Kumar and Hidayatullah G. Munshi SECTION II: NOVEL THERAPEUTIC APPROACHES TARGETING RAS AND RELATED PATHWAYS 8. Search for Inhibitors of Ras-Driven Cancers / Adam B. Keeton and Gary A. Piazza 9. GTP-competitive inhibitors of RAS family members / John C. Hunter and Kenneth D. Westover 10. Next generation strategies to target RAF / Darrin D. Stuart 11. Targeting metabolic vulnerabilities in Ras-mutant cells / Aparna D Rao and Grant A McArthur 12. Blocking SIAH proteolysis, an important K-RAS vulnerability, to control and eradicate K-RAS-driven metastatic cancer / Robert Van Sciver, Monicah M. Njogu, Andrew J. Isbell, Justin J. Odanga, Minglei Bian, Elizaveta Svyatova, Lauren L. Siewertsz van Reesema, Vasilena Zheleva, Jamie L. Eisner, Jamie K. Bruflat, Rebecca L. Schmidt, Angela M. Tang-Tan, and Amy H. Tang 13. Extracellular signal-regulated kinases (ERK1 and ERK2) Inhibitors / Ahmad Samatar 14. Targeting Rho, Rac, CDC42 GTPase effector p21 activated kinases in cancer / Asfar Sohail Azmi; Philip A. Philip