Complex Interventions in Health

Foreword 1. The Complex Interventions Framework 2. Knowledge for Healthcare Practice 3. The Value of Mixed Methods for Researching Complex Interventions 4. The Critical Importance of Patient and Public Involvement for Research into Complex Interventions Part 1: Developing Complex Interventions Part 1 Introduction 5. Systematic Reviews of the Effects of Interventions 6. Advanced Approaches to Evidence Synthesis and its Application to Intervention Design 7. Exploring Complexity in Systematic Reviews of Complex Interventions 8. The Synthesis of Qualitative Data 9. Building a Case for Mixed Method Reviews 10. Development of Complex Interventions: Outcome Modelling 11. Designing Interventions to Change Health-related Behaviour 12. Modelling Process and Outcomes in Complex Interventions Part 2: Investigating the Feasibility and Undertaking Pilot Testing of Complex Interventions: An Introduction Part 2 Introduction 13. Pilot Studies and Feasibility Studies for Complex Interventions: An Introduction 14. How to Use Feasibility and Pilot Trials to Test Alternative Methodologies and Methodological Procedures Prior to Full Scale Trials 15. How to Use Feasibility Studies to Derive Parameter Estimates in Order to Power a Full Trial16. Addressing Issues in Recruitment and Retention Using Feasibility and Pilot Trials 17. Testing the Waters: Piloting a Complex Intervention 18. Feasibility in Practice: Undertaking a Feasibility Study to Answer Procedural, Methodological and Clinical Questions Prior to a Full-scale Evaluation Part 3: Evaluation of Complex Interventions Part 3 Introduction 19. Individually and Cluster Randomised Trials 20. Stepped Wedge, Natural Experiments and Interrupted Time Series Analysis Design 21. Non-standard and Preference Designs 22. Single-subject Designs 23. Process Evaluation of Complex Interventions: A Summary of Medical Research Council Guidance 24. Intervention Fidelity in Clinical Trials 25. Qualitative Process Evaluation for Complex Interventions 26. Economic Evaluations of Complex Interventions Part 4: Implementation of Complex Interventions Part 4 Introduction 27. Implementation Issues: Towards a Systematic and Stepwise Approach 28. Why do Barriers and Facilitators Matter? 29. How to Arrive at an Implementation Plan 30. Applying Normalization Process Theory to the Implementation of Complex Interventions 31. Action Research for the Implementation of Complex Interventions 32. Systems Modelling for Improving Healthcare 33. A Few Final Thoughts