| Symposium Participants | |
| Foreword | |
| Introduction | |
| Biological Rhythms Workshop I: Introduction to Chronobiology | p. 1 |
| Biological Rhythms Workshop IA: Molecular Basis of Rhythms Generation | p. 7 |
| Biological Rhythms Workshop IB: Neurophysiology of SCN Pacemaker Function | p. 21 |
| Biological Rhythms Workshop IC: Sleep and Rhythms | p. 35 |
| Clockworks | |
| A Cyanobacterial Circadian Clock Based on the Kai Oscillator | p. 47 |
| A Circadian Clock in Neurospora: How Genes and Proteins Cooperate to Produce a Sustained, Entrainable, and Compensated Biological Oscillator with a Period of about a Day | p. 57 |
| A PER/TIM/DBT Interval Timer for Drosophila s Circadian Clock | p. 69 |
| Transcriptional Feedback and Definition of the Circadian Pacemaker in Drosophila and Animals | p. 75 |
| Genetic and Molecular Analysis of the Central and Peripheral Circadian Clockwork of Mice | p. 85 |
| The Multiple Facets of Per2 | p. 95 |
| Chromatin Remodeling and Circadian Control: Master Regulator CLOCK Is an Enzyme | p. 105 |
| The Ancestral Circadian Clock of Monarch Butterflies: Role in Time-compensated Sun Compass Orientation | p. 113 |
| Structure and Function of Animal Cryptochromes | p. 119 |
| Structure Function Analysis of Mammalian Cryptochromes | p. 133 |
| Posttranscriptional and Posttranslational Mechanisms | |
| The Gonyaulax Clock at 50: Translational Control of Circadian Expression | p. 141 |
| Posttranscriptional Regulation of Mammalian Circadian Clock Output | p. 145 |
| Biological Clocks and the Coordination Theory of RNA Operons and Regulons | p. 157 |
| Role of Phosphorylation in the Mammalian Circadian Clock | p. 167 |
| Posttranslational Regulation of Neurospora Circadian Clock by CK1a-dependent Phosphorylation | p. 177 |
| Posttranslational Control of the Neurospora Circadian Clock | p. 185 |
| Posttranslational Photomodulation of Circadian Amplitude | p. 193 |
| Genetics of Rhythms | |
| Circadian Output, Input, and Intracellular Oscillators: Insights into the Circadian Systems of Single Cells | p. 201 |
| Principles and Problems Revolving Round Rhythm-related Genetic Variants | p. 215 |
| Synchronization of the Drosophila Circadian Clock by Temperature Cycles | p. 233 |
| What Is There Left to Learn about the Drosophila Clock? | p. 243 |
| Genetics and Neurobiology of Circadian Clocks in Mammals | p. 251 |
| The Biology of the Circadian Ck1e tau Mutation in Mice and Syrian Hamsters: A Tale of Two Species | p. 261 |
| Novel Insights from Genetic and Molecular Characterization of the Human Clock | p. 273 |
| Entrainment and Peripheral Clocks | |
| Circadian Entrainment of Neurospora crassa | p. 279 |
| Constant Darkness Is a Mammalian Biological Signal | p. 287 |
| Entrainment of the Human Circadian Clock | p. 293 |
| Peripheral Clocks: Keeping Up with the Master Clock | p. 301 |
| Physiological Importance of a Circadian Clock Outside the Suprachiasmatic Nucleus | p. 307 |
| Regulation of Circadian Gene Expression in Liver by Systemic Signals and Hepatocyte Oscillators | p. 319 |
| Systems Approaches to Biological Clocks | |
| Integrating the Circadian Oscillator into the Life of the Cyanobacterial Cell | p. 331 |
| The Yeast Metabolic Cycle: Insights into the Life of a Eukaryotic Cell | p. 339 |
| Complexity of the Neurospora crassa Circadian Clock System: Multiple Loops and Oscillators | p. 345 |
| The Diurnal Project: Diurnal and Circadian Expression Profiling, Model-based Pattern Matching, and Promoter Analysis | p. 353 |
| Systems Biology of Mammalian Circadian Clocks | p. 365 |
| High-resolution Time Course Analysis of Gene Expression from Pituitary | p. 381 |
| Nuclear Receptors, Metabolism, and the Circadian Clock | p. 387 |
| Models | |
| Bacterial Circadian Programs | p. 395 |
| Stochastic Phase Oscillators and Circadian Bioluminescence Recordings | p. 405 |
| Reversible Protein Phosphorylation Regulates Circadian Rhythms | p. 413 |
| Evolution of the Clock from Yeast to Man by Period Doubling Folds in the Cellular Oscillator | p. 421 |
| Development, Proliferation, and Aging | |
| Intracellular Developmental Timers | p. 431 |
| Transcriptional Feedback Loop Regulation, Function, and Ontogeny in Drosophila | p. 437 |
| Building the Spine: The Vertebrate Segmentation Clock | p. 445 |
| Ultradian Oscillators in Somite Segmentation and Other Biological Events | p. 451 |
| The Role of Circadian Regulation in Cancer | p. 459 |
| Cross-talks between Circadian Timing System and Cell Division Cycle Determine Cancer Biology and Therapeutics | p. 465 |
| The Clock Proteins, Aging, and Tumorigenesis | p. 477 |
| Sirtuins in Aging and Disease | p. 483 |
| Identification of Caenorhabditis elegans Genes Regulating Longevity Using Enhanced RNAi-sensitive Strains | p. 489 |
| Neuroanatomy and Circuits | |
| Circadian Photoreception in Vertebrates | p. 499 |
| Multiple Photoreceptors Contribute to Nonimage-forming Visual Functions Predominantly through Melanopsin-containing Retinal Ganglion Cells | p. 509 |
| The Lateral and Dorsal Neurons of Drosophila melanogaster: New Insights about Their Morphology and Function | p. 517 |
| Exploring Spatiotemporal Organization of SCN Circuits | p. 527 |
| Inducible Clocks: Living in an Unpredictable World | p. 543 |
| Suprachiasmatic Nucleus Clock Time in the Mammalian Circadian System | p. 551 |
| Sleep, Seasons, and Mood | |
| Molecular Analysis of Sleep:Wake Cycles in Drosophila | p. 557 |
| Neurohormonal and Neuromodulatory Control of Sleep in Drosophila? | p. 565 |
| Molecular Analysis of Sleep | p. 573 |
| Sleep and Circadian Rhythms in Humans | p. 579 |
| Thermosensitive Splicing of a Clock Gene and Seasonal Adaptation | p. 599 |
| Endogenous Circannual Clock and HP Complex in a Hibernation Control System | p. 607 |
| On the Chronobiology of Cohabitation | p. 615 |
| Melatonin and Human Chronobiology | p. 623 |
| A Role for the Clock Gene in Bipolar Disorder | p. 637 |
| The Possible Interplay of Synaptic and Clock Genes in Autism Spectrum Disorders | p. 645 |
| Summary. Circadian Clocks: 50 Years On | p. 655 |
| Author Index | p. 661 |
| Subject Index | p. 663 |
| Table of Contents provided by Blackwell. All Rights Reserved. |
