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Chemoreception : From Cellular Signaling to Functional Plasticity - Jean-Marc Pequignot


From Cellular Signaling to Functional Plasticity

By: Jean-Marc Pequignot (Editor), Constancio Gonzalez (Editor), Colin A. Nurse (Editor), Nanduri R. Prabhakar (Editor), Yvette Dalmaz (Editor)

Hardcover Published: 31st October 2003
ISBN: 9780306478680
Number Of Pages: 633

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Proceedings of the XVth International Symposium on Arterial Chemoreception held, November 18-22, 2002, in Lyon, France.
During the last decade the fascinating field of oxygen-sensing has evolved from the findings of further oxygen sensing cells both in peripheral and central tissues, of molecules and channels implicated in chemoreception, and of transcriptional factors controlling the expression of a number of genes involved in physiological responses to hypoxia. In order to take into account these new aspects of chemoreception, this volume presents a multidisciplinary approach at the interface of cellular, molecular biology and integrative physiology with the main objective to elucidate the chemosensory processes and associated cardiorespiratory functions in hypoxic/hypercapnic environmental conditions.
Specifically, the volume presents up to date major aspects of the chemoreceptor pathway from molecular and cellular signalling processes in the carotid body and other oxygen-sensing structures to central integration of chemosensory inputs and systemic implications. Because sustained changes in oxygen homeostasis are able to induce morphofunctional remodeling which remains poorly understood but may provide further ways of research in physiology and pathophysiology, two sessions were devoted to the mechanisms involved in the processes of plasticity induced by long-term or intermittent hypoxia during the perinatal period or at adulthood.

Honoring Pierre Dejours His Contribution to the Study of the Role of the Arterial Chemoreceptors in the Regulation of Breathing in Humansp. 1
O[subscript 2] and CO[subscript 2] Sensing Mechanisms in the Peripheral Arterial Chemoreceptors: Membrane Properties, Intracellular Metabolic and Genomic Events
2P Domain K[superscript +] Channels: Novel Pharmacological Targets for Volatile General Anestheticsp. 9
Ca[superscript 2+] Responses to Hypoxia are Mediated by IP[subscript 3]-R on Ca[superscript 2+] Store Depletionp. 25
Functional Identification of Kv[alpha] Subunits Contributing to the O[subscript 2]-sensitive K[superscript +] Current in Rabbit Carotid Body Chemoreceptor Cellsp. 33
Carotid Body Chemoreceptor Activity in Mice Deficient in Selected Subunits of NADPH Oxidasep. 41
Glucose Sensing Cells in the Carotid Bodyp. 47
Effect of Mitochondrial Inhibitors on Type I Cellsp. 55
Ascorbate in the Carotid Bodyp. 59
Studies on Glomus Cell Sensitivity to Hypoxia in Carotid Body Slicesp. 65
An Unusual Cytochrome a[subscript 592] with low PO[subscript 2] Affinity Correlates with Afferent Discharge in the Carotid Bodyp. 75
A Reevaluation of the Mechanisms Involved in the Secretion of Catecholamine Evoked by 2.4 Dinitrophenol From Chemoreceptors Cells of the Rabbit Carotid Bodyp. 85
Enhancing Effect of Vasopressin on the Hyperglycaemic Response to Carotid Body Chemoreceptor Stimulation. Role of Metabolic Variablesp. 95
Immunohistochemical Study of the Carotid Body during Acute Hypoxiap. 109
Effect of HERG-like Potassium Channel Blocker on the Carotid Body Chemoreceptionp. 117
The Effect of Methanandamide on Isolated Type I Cellsp. 123
Doxapram Stimulates Carotid Body with Different Mechanisms from Hypoxic Chemotransductionp. 129
Neuromuscular Blocking Agents and Carotid Body Oxygen Sensingp. 135
O[subscript 2] and CO[subscript 2] Sensing Mechanisms in Airway Chemoreceptors, Pulmonary Artery Smooth Muscle Cells and Other Oxygen-sensing Systems: Membrane Properties, Intracellular Metabolic and Genomic Events
Pulmonary Interstitium: an Introductory Reviewp. 141
Regulation of K[superscript +] Currents by CO in Carotid Body Type 1 Cells and Pulmonary Artery Smooth Muscle Cellsp. 147
Ionotropic Receptors in Pulmonary Neuroepithelial Bodies (NEB) and their Possible Role in Modulation of Hypoxia Signallingp. 155
Mitochondrial Complex II is Essential for Hypoxia-induced ROS Generation and Vasoconstriction in the Pulmonary Vasculaturep. 163
Regulation of the Hypoxia-inducible Transcription Factor HIF-1 by Reactive Oxygen Species in Smooth Muscle Cellsp. 171
O[subscript 2]-sensing Mechanisms in Efferent Neurons to the Rat Carotid Bodyp. 179
Amyloid Peptide-mediated Hypoxic Regulation of Ca[superscript 2+] Channels in PC12 Cellsp. 187
Role of ROS and NO in Hypoxia-induced Increase in Tyrosine Hydroxylase-messenger RNA in PC12 Cellsp. 193
Oxygen Sensing by Human Recombinant Tandem-P Domain Potassium Channelsp. 201
Oxygen Sensing by Human Recombinant Large Conductance Calcium-activated Potassium Channels: Regulation by Acute Hypoxiap. 209
Potential Oxygen Sensing Pathways in the Zebrafish Gillp. 217
Sensory Neurons of Rat and Mice Dorsal Root Ganglia Respond to Hypoxia with Increased NO Generationp. 225
Molecular Mechanisms of Oxygen-induced Regulation of NA[superscript +]/K[superscript +] Pumpp. 231
The Paraganglia of the Rat Superior Laryngeal Nervep. 239
Mechanisms of Communication Between Chemosensory Cells and Chemoafferent Fibers
Dye and Electric Coupling Between Carotid Nerve Terminals and Glomus Cellsp. 247
Neurotransmitter Relationships in the Hypoxia-challenged Cat Carotid Bodyp. 255
Ach Differentially Modulates Voltage-gated K Channels in Glomus Cells between DBA/2J and A/J Strains of Micep. 263
Hypoxic Augmentation of Neuronal Nicotinic Acetylcholine Receptors and Carotid Body Functionp. 269
Cholinergic Actions on Carotid Chemosensory Systemp. 277
Nicotinic Acetylcholine Receptor Channels in Cat Chemoreceptor Cellsp. 285
Hypoxia Does Not Uniformly Facilitate The Release of Multiple Transmitters from the Carotid Bodyp. 291
Expression and Function of Pre-synaptic Neurotransmitter Receptors in the Chemoafferent Pathway of the Rat Carotid Bodyp. 297
Adenosine-Acetylcholine Interactions at the Rat Carotid Bodyp. 305
Diverse Cholinergic Receptors in the Cat Carotid Chemosensory Unitp. 313
Carotid Chemosensory Neurons in the Petrosal Ganglia are Excited by Ach and ATPp. 321
The Use of NK-1 Receptor Null Mice to Assess the Significance of Substance P in the Carotid Body Functionp. 327
Concomitant Effect of Acetylcholine and Dopamine on Carotid Chemosensory Activity in Catecholamine Depleted Catsp. 337
Contribution of Neural and Endothelial Isoforms of the Nitric Oxide Synthase to the Inhibitory Effects of NO on the Cat Carotid Bodyp. 345
Nitric Oxide and Calcium Binding Protein in Hypoxic Rat Carotid Bodyp. 353
Carotid Body Nitric Oxide in Spontaneously Diabetic BB Ratp. 359
Contribution of Dopamine D2 Receptors for the cAMP Levels at the Carotid Bodyp. 367
Brainstem O[subscript 2] and CO[subscript 2] Sensing--Central Integration of Peripheral Chemosensory Inputs
Chemosensitivity of Medullary Respiratory Neurones. A Role for Ionotropic P2X and GABA[subscript A] Receptorsp. 375
Effects of Controller Dynamics on Stimulations of Irregular and Periodic Breathingp. 389
CO[subscript 2]/H[superscript +] Signal Tranduction and Central Ventilatory Controlp. 401
Differential Expression of Intracellular Acidosis in Rat Brainstem Regions in Response to Hypercapnic Ventilationp. 407
Tentative Role of the Na[superscript +]/H[superscript +] Exchanger Type 3 in Central Chemosensitivity of Respirationp. 415
Effect of Losartan Microinjections into the NTS on the Cardiovascular Components of Chemically Evoked Reflexes in a Rabbit Model of Acute Heart Ischemiap. 423
Effects of Acute Hypoxic Conditions on Extracellular Excitatory Amino Acids and Dopamine in the Striatum of Freely-moving Ratsp. 433
Activity of Dorsal Medullary Respiratory Neurons in Awake Ratsp. 445
Cardiovascular and Respiratory Responses to Heme Oxygenase Inhibition in Conscious Ratsp. 455
Peripheral Chemoreceptor Input to Cardiac Vagal Preganglionic Neurons in the Anaesthetized Ratp. 461
Hypoxic Remodelling of Ca[superscript 2+] Homeostasis in Rat Type 1 Cortical Astrocytesp. 467
Effect of CO[subscript 2] on Cardiovascular Regulation in Conscious Ratsp. 473
A6 noradrenergic cell group modulates the hypoxic ventilatory responsep. 481
Ventilatory Chemosensory Drive in Cats, Rats and Guinea Pigsp. 489
Plasticity of Chemosensitivity Processes During Development: Transition at Birth and Delayed Effects
Deletion of Tachykinin NK1 Receptor Gene in Mice Does Not Alter Respiratory Network Maturation but Alters Respiratory Responses to Hypoxiap. 497
Autonomic Ganglion Cells: Likely Source of Acetylcholine in the Rat Carotid Bodyp. 505
Effects of Perinatal Hyperoxia on Carotid Body Chemoreceptors Activity in vitrop. 517
Prenatal Hypoxia and Early Postnatal Maturation of the Chemoafferent Pathwayp. 525
pH Sensitivity of Spinal Cord Rhythm in Fetal Mice in vitrop. 535
Time Dependent Regulation of Dopamine D[subscript 1]- and D[subscript 2]-Receptor Gene Expression in the Carotid Body of Developing Rabbits by Hypoxiap. 541
Ventilatory Response to CO[subscript 2] in New-born Mousep. 549
Long-term Effects of Neonatal Cryoanesthesia on Hypoxic Ventilatory Response in Weaning Rats Depend on Neonatal Testosteronep. 555
Plasticity of Chemosensitive Processes: Acclimatization to Intermittent Versus Chronic Hypoxia in Adult
Systemic and Cellular Responses to Intermittent Hypoxia: Evidence for Oxidative Stress and Mitochondrial Dysfunctionp. 559
Effects of Hypobaric Hypoxia on the Intercellular Coupling of Glomus Cellsp. 565
Oxygen Sensing by Recombinant Large Conductance Calcium-activated Potassium Channels: Regulation by Chronic Hypoxiap. 573
Altered Expression of Vascular Endothelial Growth Factor and FLK-1 Receptor in Chronically Hypoxic Rat Carotid Bodyp. 583
Role of HIF-1 in Physiological Adaptation of the Carotid Body During Chronic Hypoxiap. 593
Carotid body HIF-1[alpha], VEGF and NOS Expression During Aging and Hypoxiap. 603
Rat Carotid Bodies in Systemic Hypoxia. Involvement of Arterial CO[subscript 2] Tension in Morphological Changesp. 611
Immunohistochemical Study of the Carotid Body Just After Arousal From Hibernationp. 619
Indexp. 629
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9780306478680
ISBN-10: 0306478684
Series: Advances in Experimental Medicine and Biology
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 633
Published: 31st October 2003
Country of Publication: US
Dimensions (cm): 24.23 x 19.1  x 4.52
Weight (kg): 1.42

Earn 836 Qantas Points
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