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Published: 31st October 2003
ISBN: 9780306478680
Number Of Pages: 633
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Published: 5th November 2012Proceedings of the XVth International Symposium on Arterial Chemoreception held, November 18-22, 2002, in Lyon, France.
During the last decade the fascinating field of oxygen-sensing has evolved from the findings of further oxygen sensing cells both in peripheral and central tissues, of molecules and channels implicated in chemoreception, and of transcriptional factors controlling the expression of a number of genes involved in physiological responses to hypoxia. In order to take into account these new aspects of chemoreception, this volume presents a multidisciplinary approach at the interface of cellular, molecular biology and integrative physiology with the main objective to elucidate the chemosensory processes and associated cardiorespiratory functions in hypoxic/hypercapnic environmental conditions.
Specifically, the volume presents up to date major aspects of the chemoreceptor pathway from molecular and cellular signalling processes in the carotid body and other oxygen-sensing structures to central integration of chemosensory inputs and systemic implications. Because sustained changes in oxygen homeostasis are able to induce morphofunctional remodeling which remains poorly understood but may provide further ways of research in physiology and pathophysiology, two sessions were devoted to the mechanisms involved in the processes of plasticity induced by long-term or intermittent hypoxia during the perinatal period or at adulthood.
| Honoring Pierre Dejours His Contribution to the Study of the Role of the Arterial Chemoreceptors in the Regulation of Breathing in Humans | p. 1 |
| O[subscript 2] and CO[subscript 2] Sensing Mechanisms in the Peripheral Arterial Chemoreceptors: Membrane Properties, Intracellular Metabolic and Genomic Events | |
| 2P Domain K[superscript +] Channels: Novel Pharmacological Targets for Volatile General Anesthetics | p. 9 |
| Ca[superscript 2+] Responses to Hypoxia are Mediated by IP[subscript 3]-R on Ca[superscript 2+] Store Depletion | p. 25 |
| Functional Identification of Kv[alpha] Subunits Contributing to the O[subscript 2]-sensitive K[superscript +] Current in Rabbit Carotid Body Chemoreceptor Cells | p. 33 |
| Carotid Body Chemoreceptor Activity in Mice Deficient in Selected Subunits of NADPH Oxidase | p. 41 |
| Glucose Sensing Cells in the Carotid Body | p. 47 |
| Effect of Mitochondrial Inhibitors on Type I Cells | p. 55 |
| Ascorbate in the Carotid Body | p. 59 |
| Studies on Glomus Cell Sensitivity to Hypoxia in Carotid Body Slices | p. 65 |
| An Unusual Cytochrome a[subscript 592] with low PO[subscript 2] Affinity Correlates with Afferent Discharge in the Carotid Body | p. 75 |
| A Reevaluation of the Mechanisms Involved in the Secretion of Catecholamine Evoked by 2.4 Dinitrophenol From Chemoreceptors Cells of the Rabbit Carotid Body | p. 85 |
| Enhancing Effect of Vasopressin on the Hyperglycaemic Response to Carotid Body Chemoreceptor Stimulation. Role of Metabolic Variables | p. 95 |
| Immunohistochemical Study of the Carotid Body during Acute Hypoxia | p. 109 |
| Effect of HERG-like Potassium Channel Blocker on the Carotid Body Chemoreception | p. 117 |
| The Effect of Methanandamide on Isolated Type I Cells | p. 123 |
| Doxapram Stimulates Carotid Body with Different Mechanisms from Hypoxic Chemotransduction | p. 129 |
| Neuromuscular Blocking Agents and Carotid Body Oxygen Sensing | p. 135 |
| O[subscript 2] and CO[subscript 2] Sensing Mechanisms in Airway Chemoreceptors, Pulmonary Artery Smooth Muscle Cells and Other Oxygen-sensing Systems: Membrane Properties, Intracellular Metabolic and Genomic Events | |
| Pulmonary Interstitium: an Introductory Review | p. 141 |
| Regulation of K[superscript +] Currents by CO in Carotid Body Type 1 Cells and Pulmonary Artery Smooth Muscle Cells | p. 147 |
| Ionotropic Receptors in Pulmonary Neuroepithelial Bodies (NEB) and their Possible Role in Modulation of Hypoxia Signalling | p. 155 |
| Mitochondrial Complex II is Essential for Hypoxia-induced ROS Generation and Vasoconstriction in the Pulmonary Vasculature | p. 163 |
| Regulation of the Hypoxia-inducible Transcription Factor HIF-1 by Reactive Oxygen Species in Smooth Muscle Cells | p. 171 |
| O[subscript 2]-sensing Mechanisms in Efferent Neurons to the Rat Carotid Body | p. 179 |
| Amyloid Peptide-mediated Hypoxic Regulation of Ca[superscript 2+] Channels in PC12 Cells | p. 187 |
| Role of ROS and NO in Hypoxia-induced Increase in Tyrosine Hydroxylase-messenger RNA in PC12 Cells | p. 193 |
| Oxygen Sensing by Human Recombinant Tandem-P Domain Potassium Channels | p. 201 |
| Oxygen Sensing by Human Recombinant Large Conductance Calcium-activated Potassium Channels: Regulation by Acute Hypoxia | p. 209 |
| Potential Oxygen Sensing Pathways in the Zebrafish Gill | p. 217 |
| Sensory Neurons of Rat and Mice Dorsal Root Ganglia Respond to Hypoxia with Increased NO Generation | p. 225 |
| Molecular Mechanisms of Oxygen-induced Regulation of NA[superscript +]/K[superscript +] Pump | p. 231 |
| The Paraganglia of the Rat Superior Laryngeal Nerve | p. 239 |
| Mechanisms of Communication Between Chemosensory Cells and Chemoafferent Fibers | |
| Dye and Electric Coupling Between Carotid Nerve Terminals and Glomus Cells | p. 247 |
| Neurotransmitter Relationships in the Hypoxia-challenged Cat Carotid Body | p. 255 |
| Ach Differentially Modulates Voltage-gated K Channels in Glomus Cells between DBA/2J and A/J Strains of Mice | p. 263 |
| Hypoxic Augmentation of Neuronal Nicotinic Acetylcholine Receptors and Carotid Body Function | p. 269 |
| Cholinergic Actions on Carotid Chemosensory System | p. 277 |
| Nicotinic Acetylcholine Receptor Channels in Cat Chemoreceptor Cells | p. 285 |
| Hypoxia Does Not Uniformly Facilitate The Release of Multiple Transmitters from the Carotid Body | p. 291 |
| Expression and Function of Pre-synaptic Neurotransmitter Receptors in the Chemoafferent Pathway of the Rat Carotid Body | p. 297 |
| Adenosine-Acetylcholine Interactions at the Rat Carotid Body | p. 305 |
| Diverse Cholinergic Receptors in the Cat Carotid Chemosensory Unit | p. 313 |
| Carotid Chemosensory Neurons in the Petrosal Ganglia are Excited by Ach and ATP | p. 321 |
| The Use of NK-1 Receptor Null Mice to Assess the Significance of Substance P in the Carotid Body Function | p. 327 |
| Concomitant Effect of Acetylcholine and Dopamine on Carotid Chemosensory Activity in Catecholamine Depleted Cats | p. 337 |
| Contribution of Neural and Endothelial Isoforms of the Nitric Oxide Synthase to the Inhibitory Effects of NO on the Cat Carotid Body | p. 345 |
| Nitric Oxide and Calcium Binding Protein in Hypoxic Rat Carotid Body | p. 353 |
| Carotid Body Nitric Oxide in Spontaneously Diabetic BB Rat | p. 359 |
| Contribution of Dopamine D2 Receptors for the cAMP Levels at the Carotid Body | p. 367 |
| Brainstem O[subscript 2] and CO[subscript 2] Sensing--Central Integration of Peripheral Chemosensory Inputs | |
| Chemosensitivity of Medullary Respiratory Neurones. A Role for Ionotropic P2X and GABA[subscript A] Receptors | p. 375 |
| Effects of Controller Dynamics on Stimulations of Irregular and Periodic Breathing | p. 389 |
| CO[subscript 2]/H[superscript +] Signal Tranduction and Central Ventilatory Control | p. 401 |
| Differential Expression of Intracellular Acidosis in Rat Brainstem Regions in Response to Hypercapnic Ventilation | p. 407 |
| Tentative Role of the Na[superscript +]/H[superscript +] Exchanger Type 3 in Central Chemosensitivity of Respiration | p. 415 |
| Effect of Losartan Microinjections into the NTS on the Cardiovascular Components of Chemically Evoked Reflexes in a Rabbit Model of Acute Heart Ischemia | p. 423 |
| Effects of Acute Hypoxic Conditions on Extracellular Excitatory Amino Acids and Dopamine in the Striatum of Freely-moving Rats | p. 433 |
| Activity of Dorsal Medullary Respiratory Neurons in Awake Rats | p. 445 |
| Cardiovascular and Respiratory Responses to Heme Oxygenase Inhibition in Conscious Rats | p. 455 |
| Peripheral Chemoreceptor Input to Cardiac Vagal Preganglionic Neurons in the Anaesthetized Rat | p. 461 |
| Hypoxic Remodelling of Ca[superscript 2+] Homeostasis in Rat Type 1 Cortical Astrocytes | p. 467 |
| Effect of CO[subscript 2] on Cardiovascular Regulation in Conscious Rats | p. 473 |
| A6 noradrenergic cell group modulates the hypoxic ventilatory response | p. 481 |
| Ventilatory Chemosensory Drive in Cats, Rats and Guinea Pigs | p. 489 |
| Plasticity of Chemosensitivity Processes During Development: Transition at Birth and Delayed Effects | |
| Deletion of Tachykinin NK1 Receptor Gene in Mice Does Not Alter Respiratory Network Maturation but Alters Respiratory Responses to Hypoxia | p. 497 |
| Autonomic Ganglion Cells: Likely Source of Acetylcholine in the Rat Carotid Body | p. 505 |
| Effects of Perinatal Hyperoxia on Carotid Body Chemoreceptors Activity in vitro | p. 517 |
| Prenatal Hypoxia and Early Postnatal Maturation of the Chemoafferent Pathway | p. 525 |
| pH Sensitivity of Spinal Cord Rhythm in Fetal Mice in vitro | p. 535 |
| Time Dependent Regulation of Dopamine D[subscript 1]- and D[subscript 2]-Receptor Gene Expression in the Carotid Body of Developing Rabbits by Hypoxia | p. 541 |
| Ventilatory Response to CO[subscript 2] in New-born Mouse | p. 549 |
| Long-term Effects of Neonatal Cryoanesthesia on Hypoxic Ventilatory Response in Weaning Rats Depend on Neonatal Testosterone | p. 555 |
| Plasticity of Chemosensitive Processes: Acclimatization to Intermittent Versus Chronic Hypoxia in Adult | |
| Systemic and Cellular Responses to Intermittent Hypoxia: Evidence for Oxidative Stress and Mitochondrial Dysfunction | p. 559 |
| Effects of Hypobaric Hypoxia on the Intercellular Coupling of Glomus Cells | p. 565 |
| Oxygen Sensing by Recombinant Large Conductance Calcium-activated Potassium Channels: Regulation by Chronic Hypoxia | p. 573 |
| Altered Expression of Vascular Endothelial Growth Factor and FLK-1 Receptor in Chronically Hypoxic Rat Carotid Body | p. 583 |
| Role of HIF-1 in Physiological Adaptation of the Carotid Body During Chronic Hypoxia | p. 593 |
| Carotid body HIF-1[alpha], VEGF and NOS Expression During Aging and Hypoxia | p. 603 |
| Rat Carotid Bodies in Systemic Hypoxia. Involvement of Arterial CO[subscript 2] Tension in Morphological Changes | p. 611 |
| Immunohistochemical Study of the Carotid Body Just After Arousal From Hibernation | p. 619 |
| Index | p. 629 |
| Table of Contents provided by Ingram. All Rights Reserved. |
ISBN: 9780306478680
ISBN-10: 0306478684
Series: Advances in Experimental Medicine and Biology
Audience:
General
Format:
Hardcover
Language:
English
Number Of Pages: 633
Published: 31st October 2003
Publisher: SPRINGER VERLAG GMBH
Country of Publication: US
Dimensions (cm): 24.23 x 19.1
x 4.52
Weight (kg): 1.42
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