Chemically Imbalanced

The Making and Unmaking of the Serotonin Myth

By: JOANNA MONCRIEFF

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Paperback | 3 September 2026

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For years, we've been led to believe that depression is caused by a chemical imbalance in the brain and antidepressants are the solution. But what if this widely accepted belief has been built on unreliable truths? In Chemically Imbalanced, renowned psychiatrist Joanna Moncrieff takes readers on a thought-provoking journey through the history of the serotonin theory of depression, from its origins in the 1960s to its widespread acceptance in the 1990s. With clarity and compelling evidence, Moncrieff exposes how scientific understanding has been swayed by social and economic forces, leading to misconceptions that have shaped treatment decisions for millions. Accessible yet profoundly insightful, Chemically Imbalanced is essential reading for anyone seeking to make more informed choices about their mental health and understand the forces that shape the way we perceive and treat depression today. AUTHOR: Joanna Moncrieff is Professor of Critical and Social Psychiatry at University College London, and a consultant psychiatrist for the NHS. She is an expert in the field, and in 2022 she was the lead author of a landmark study into the theory of serotonin and depression. She is a founder member and co-chairperson of the Critical Psychiatry Network, an influential network of psychiatrists and other doctors. She has written for The Guardian, Daily Mail, The Conversation, Literary Review, was profiled in the Spectator magazine and has been interviewed for The Guardian's Science Weekly podcast and the Evening Standard's Tech and Science Daily, amongst others.

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