Chapter 1
FROM "AUTISM RESEARCH BETWEEN PSYCHOLOGY AND NEUROSCIENCE" TO "A PERSPECTIVE ON THE NEUROBIOLOGICAL BASIS OF AUTISM AND NEW FRONTIERS".
Chapter 2
THE ROLE OF BDNF IN THE ONSET OF AUTISM
⢠The Thesis I Proposed
⢠The Role of BDNF
⢠The BDNF Dysfunction/Disregulation Thesis
⢠The Basis of Genetic Susceptibility
⢠Experimental Evidence (Updated)
⢠A Unified Proposal
⢠The Central Role of BDNF
⢠A Different Definition of Autism
Chapter 3
THE ORIGIN OF CONNECTOPATHY: A CIRCUIT HYPOTHESIS OF NEUROINFLAMMATION AND BDNF DYSREGULATION IN THE ONSET OF AUTISM
⢠Autism as a Connectopathy
⢠The Neuroinflammatory Hypothesis
⢠Patterns of the Neuroinflammatory Process
Chapter 4
GENETICS, EPIGENETICS AND ENVIRONMENT IN AUTISM
⢠From Genetic Susceptibility To Epigenetics
⢠The Immune System Of The Brain And Its Relationship With The Digestive System
⢠Gastrointestinal Problems In Autistic People
Chapter 5
GENETIC RESEARCH INTO AUTISM: THE âGENETIC SUSCEPTIBILITY BASISâ
⢠Molecular Genetics and the Emergence of the âAutism Spectrumâ
⢠"De Novo" Mutations
⢠The Overall State of Autism Genetics Research
⢠Major Genes Involved in Autism
Chapter 6
THE CENTRAL ROLE OF SHANK FAMILY GENES IN INFLAMMATION AND AUTISM
⢠The SHANK Protein Family
⢠The Shank-Inflammation Link
⢠Shank-Zinc Correlation
⢠Synaptic assembly of ProSAP1/Shank2 and ProSAP2/Shank3 proteins is affected by Zn2+ deficiency
Chapter 7
CEREBRAL CHARACTERISTICS IN AUTISM AND THE ROLE OF SHANK FAMILY GENES
⢠The Role of Shank Family Genes in Synaptic Configuration
⢠The Association Of The AMPA Receptor With Dysfunction The Cerebro-Cerebellar Circuit in Autism
⢠AMPA Receptors And Dendritic Compartment Physiology
⢠Phelan Mcdermid syndrome, 22q13 deletion And Other Autistic Etiologies Related To SHANK3
⢠Cerebellar Involvement in Autism
⢠Cerebellar Anatomy And Neuronal Specification
Chapter 8
SHANK GENES, ZINC AND GLUTAMATE RECEPTORS IN THE AETIOLOGY OF AUTISM
⢠NMDAR and Synaptic Plasticity
⢠Zinc and NMDAR
⢠Pathological Effects on NMDAR Receptors
⢠Role of SHANKs with NMDAR in Autism Spectrum Disorders
Chapter 9
DOPAMINE RECEPTORS IN THE ETIOLOGY OF AUTISM
⢠Dopamine BDNF and Autism Ontogenesis
⢠Mesolimbic DAergic Social Reward, Brain Excitatory-Inhibitory Balance and Autism
⢠Dysregulated Neurotransmitter Signaling in Autism
⢠DAergic Dysregulation and Neurocognitive Manifestations in Autism
Chapter 10
THE ROLE OF ZINC AND THE IMMUNE SYSTEM IN THE AETIOLOGY OF AUTISM
⢠The Role Of Zinc
⢠Zinc's Role in the Immune System
⢠Zinc-Serotonin Interaction
⢠Zinc and the Immune System
⢠The Relationship Between Zinc's Role in Metabolism And the Comorbidities of Autism
⢠Sensory Perception, Food Selectivity And Zn In Autistic People
⢠Biomarkers of Autism
⢠Zinc And Microbiota In Autism
Chapter 11
INFLAMMATORY PROCESSES IN THE PATHOGENESIS OF AUTISM
⢠Microglia-Mediated Neuroinflammation
⢠Neuroinflammation in Autism
⢠The Role of H3R in Microglial Activation And Neuroinflammation in Autism
Chapter 12
THE ROLE OF ZINC IN INFLAMMATION PROCESS IN THE AETIOLOGY OF AUTISM
⢠The Role of Zinc
⢠NF-κB and Other Signaling Pathways
⢠Oxidative Stress
⢠Zinc Status and Inflammatory Cytokines
⢠Zinc in Infection and Nutritional Immunity
⢠Zinc as a Critical Component of the Membrane Barrier
Chapter 13
PRENATAL INFECTION AND INFLAMMATION IN THE AETIOLOGY OF AUTISM
⢠MicroRNA Dysregulation in the Pathophysiology of Autism
Chapter 14
THE ROLE OF METALS AND TRACE ELEMENTS IN THE AETIOLOGY OF AUTISM
⢠Trace Elements Characteristics And Their Roles in Biological Functions
⢠The Role of Trace Metals in Autism
⢠Individual Elements
⢠Trace Metal Homeostasis and Autism
⢠Mechanisms Involved in Environmental Influence On Neurodevelopment
Chapter 15
PATHOMECHANISM OF METALS IN AUTISM
⢠Association Between Autism And Metals
⢠Pathomechanisms of Heavy Metal Overload in Autism
⢠Oxidative Stress and Mitochondrial Dysfunction
⢠Neuroinflammation
⢠Axonal Demyelination
⢠Competition with Essential Metals and Specifically Zinc
⢠Toxic Metals That Cause Zinc Deficiency
⢠Deficiencies
Chapter 16
THE ROLE OF SUSCEPTIBILITY-INDUCING COFACTORS IN THE AETIOLOGY OF AUTISM: ACETAMINOPHEN, PARACETAMOL AND GLYSOPHATE
⢠Acetaminophen Metabolism
⢠Acetaminophen and Glyphosate Emergencies
⢠The Role of Vasostatin1 in the Neuroinflammatory Process
Chapter 17
NEW DIAGNOSTIC TOOLS (NOT ONLY) FOR AUTISM
⢠How Artificial Intelligence and Machine Learning Can Contribute to Research and Diagnosis
⢠The TBM
⢠The Quantum Magnetic Resonance Analyzer (QMRA)
⢠Gaming
Chapter 18
NEW THERAPEUTIC INTERVENTION TOOLS (NOT ONLY) FOR AUTISM
⢠The Zn-Shankopathies Relationship
⢠Shank3 Lithium Treatment
⢠Zinc Deficiencies and Supplements
⢠Other Pathways of Action on Neurotransmitters and Histamine
⢠Choline Supplementation
Chapter 19 CONCLUSIONS
INDEX
⢠Names Index
⢠Word-Subjects Index
