Understanding Complex Systems

An Introduction to Complex Systems Biology

By: Kunihiko Kaneko

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Hardcover | 3 August 2006

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388 Pages

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24.13 x 15.88 x 1.91

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What is life? What type of system is life? How can we understand life? Or what does "understanding life" really mean? Sixty years since the publication of What Is Life? by Schrodinger ] and after the rise and success of molecular biology, have we reached the answer to these questions? In the recent years, I have often been asked by young researchers and students in biology: "I am afraid that such basic questions on a life system itself are not answered by the main-stream approach of c- rent biology that elucidates molecules and genes. We need some alternative approach. WhatamItodo?"Theyaresatis?edneitherwiththecurrenttrend in bioinformatics nor with the detailed computer models, and are striving for a framework complementary to molecular biology, a one that does not rely on enumerative approach. Responding to these voices, I have explained approaches my colleagues and I have been taking both theoretically and experimentally, in lectures and seminars. Although they show much interest, introduction of these rather interdisciplinary style of research is not easy, let alone discussing how we can understand life. Of course they ask for some books that describe a theoretical basis of our approach and the summaries of the recent studies. My desire to answer these requests from the students and researchers was the main force that had driven me to write the present book. On the other hand, those working in nonlinear dynamics and theoretical physicshavestrivedtosetupanoveltheoreticalframeworkthatiscompatible with biological systems.

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Published: 25th November 2010

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How should living systems be studied?	p. 1
Constructive biology	p. 37
Basic concepts in dynamical systems	p. 47
Origin of bioinformation	p. 81
Origin of a cell with recursive growth	p. 111
Universal statistics of a cell with recursive growth	p. 135
Cell differentiation and development	p. 159
Irreversible differentiation from stem cell and robust development	p. 193
Pattern formation and origin of positional information	p. 227
Genetic evolution with phenotypic fluctuations	p. 255
Speciation as a fixation of phenotypic differentiation	p. 281
Conclusion	p. 315
Table of Contents provided by Blackwell. All Rights Reserved.

Understanding Complex Systems

An Introduction to Complex Systems Biology

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Hardcover

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