Understanding Ageing

By: Robin Holliday

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Paperback | 12 June 1995

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224 Pages

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22.9 x 15.1 x 1.4

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This book presents a completely novel approach to the understanding of ageing, which many believe is an unsolved problem in biology. It explains why ageing exists in animals, and reviews our understanding of it at the biological level. This includes a discussion of the origins and evolution of ageing. The book is not a review of research on ageing, but instead draws on material from a wide range of disciplines, including the very extensive biomedical information about age-related diseases in humans. Understanding Ageing argues that much research needs to be done on the cellular and molecular aspects of ageing, if the origins of these diseases are to be understood, and their prevention made possible. This thought-provoking book will appeal to all students and researchers who are interested in ageing, whether they are working in the clinical or basic research sphere.

Industry Reviews

'Robin Holliday offers a superb overview with emphasis on the cellular and molecular biology of ageing ...' Nature 'Holliday writes in a direct and energetic style that makes his text highly readable. I would certainly recommend it to students ... an excellent text.' Linda Partridge, Elsevier Trends in Ecology and Evolution

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Preface	p. ix
Author's note	p. xi
Acknowledgements	p. xiii
Introduction	p. 1
The evolved anatomical and physiological design of mammals	p. 12
Maintenance of the adult organism	p. 21
DNA repair	p. 21
Accuracy in the synthesis of macromolecules	p. 24
Defence against oxygen free radicals	p. 27
Removal of defective proteins	p. 29
The immune response	p. 31
Toxic chemicals and detoxification	p. 33
Wound healing	p. 34
Stability of differentiated cells	p. 36
Temperature control	p. 38
Physiological homeostasis	p. 39
Order and disorder	p. 39
Theories of ageing	p. 41
Somatic mutations and DNA damage	p. 41
Protein errors	p. 47
Protein modifications	p. 54
Oxygen free radicals and mitochondria	p. 56
Immunological theory	p. 59
Dysdifferentiation or epigenetic theory	p. 61
Toxicity	p. 64
Endocrine and programme theories	p. 65
Conclusions	p. 65
Cellular ageing	p. 67
The finite lifespan of cells in culture	p. 67
Transplantation experiments	p. 74
Stem cells and commitment to senescence	p. 75
Mechanisms of cellular ageing	p. 77
The immortalisation of somatic cells	p. 82
Non-dividing cells	p. 83
Apoptosis	p. 85
Genetic programmes for ageing	p. 87
The preservation of the germ line	p. 87
Ageing of the germ line?	p. 89
Regulated changes in somatic cells	p. 90
The concept of programmed ageing	p. 91
Programmed death following reproduction	p. 92
Gene mutations that change lifespan	p. 93
Microbial models	p. 95
Genes and ageing	p. 97
The evolution of longevity	p. 99
Early theories of the evolution of ageing	p. 99
The disposable soma theory	p. 101
Comparative studies of the efficiency of maintenance	p. 104
Fecundity and longevity	p. 111
Environmental effects on ageing	p. 115
Primate evolution	p. 117
Ageing is an adaptation	p. 120
Human disease and ageing	p. 122
The brain, vision and hearing	p. 123
The vascular system	p. 126
Renal function	p. 128
Late-onset diabetes	p. 129
Osteoarthritis and osteoporosis	p. 130
Skin	p. 131
The immune system	p. 132
Cancer	p. 133
Premature ageing syndromes	p. 136
Conclusions	p. 138
A better understanding of ageing	p. 139
Ageing and Darwinism	p. 139
Immortality	p. 140
Replacement of parts	p. 141
Modulation of longevity	p. 142
Single or multiple causes?	p. 144
Molecular biology of ageing	p. 147
Biomedical research and age-related disease	p. 149
Notes	p. 153
References	p. 173
Author index	p. 193
Subject index	p. 198
Table of Contents provided by Syndetics. All Rights Reserved.

Understanding Ageing

At a Glance

Paperback

Industry Reviews

Shipping

How to return your order

Defective items

You Can Find This Book In

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