Thrombin: Physiology and Disease

Physiology and Disease

By: Michael E. Maragoudakis (Editor), Nikos E. Tsopanoglou (Editor)

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Hardcover | 1 December 1979

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Hardcover
284 Pages

Dimensions(cm)
23.5 x 15.24 x 1.27

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In addition to its central role in blood coagulation, it has become increasingly apparent that thrombin and thrombin receptors are involved in many other physiological processes and can contribute to a variety of disease states such as tumor progression and metastasis, inflammation, neurological disorders and cardiovascular complications. This book is a collection of reviews of up-to-date information on the above topics by leaders in these fields.

This book will be of value to researchers and academic professionals both in basic and clinical science who are interested in the fields of biochemistry, biophysics, cell biology, pharmacology, cancer, inflammation, angiogenesis, cardiovascular system and neuronal system. These areas of research are prime target areas for drug development by many pharmaceutical and biotechnology companies.

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Thrombin: Structure, Functions, and Regulation	p. 1
Thrombin: To PAR or Not to PAR, and the Regulation of Inflammation	p. 19
Regulation of Thrombin Receptor Signaling	p. 47
Thrombin and Activated Protein C: Integrated to Regulate Vascular Physiology	p. 63
The Role of Thrombin in Vascular Development	p. 81
The Role of Thrombin in Angiogenesis	p. 93
Thrombin and Thrombin Peptides in Wound Heating and Tissue Repair	p. 115
The Role of Thrombin and Thrombin Receptors in the Brain	p. 133
The Role of Thrombin in Tumor Biology	p. 161
The Role of Thrombin and its Receptors in Epithelial Malignancies: Lessons from a Transgenic Mouse Model and Transcriptional Regulation	p. 173
Anti-thrombotic Therapy in Cancer Patients	p. 189
Thrombin Receptor Modulators: Medicinal Chemistry, Biological Evaluation, and Clinical Application	p. 205
Novel Anticoagulant Therapy: Principle and Practice	p. 237
Index	p. 259
Table of Contents provided by Blackwell. All Rights Reserved.

Thrombin: Physiology and Disease

Physiology and Disease

At a Glance

Hardcover

Shipping

How to return your order

Defective items

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