The Solid-State Mindset

Lessons, Surprises, and Strategies from the Front Lines of Drug Development

By: VÃctor M. DÃaz PÃ©rez

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Paperback | 31 January 2026

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Paperback

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22.9 x 15.2 x 0.67

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Drugs don't fail because their chemistry is wrong-they fail because their physical reality is misunderstood.
Most molecules entering development today are poorly soluble, structurally complex, and polymorphically rich. They behave unpredictably under stress, at scale, or in formulation-unless their solid-state landscape is understood from the start.
The Solid-State Mindset is a practical, insightful journey through the science that underpins every successful small-molecule program:

polymorphism and crystallisation
solubility and dissolution
amorphous materials and particle engineering
early formulation and preclinical vehicles
CMC strategy and regulatory expectations
solid-form IP, risk management, and the hidden business consequences

Drawing on years of hands-on experience in the pharmaceutical industry, Vctor M. Daz P©rez brings together real case studies-including ritonavir, paroxetine, and gatifloxacin-along with clear explanations of the physical chemistry behind them.
This book is not a manual. It is a perspective, a way of thinking that helps scientists, founders, CMC leaders, and generic manufacturers make better decisions, earlier, with fewer surprises.
If you work with small molecules, this book will change how you see your drug.

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