Get Free Shipping on orders over $79
The Histone Code and Beyond : New Approaches to Cancer Therapy - S. L. Berger

The Histone Code and Beyond

New Approaches to Cancer Therapy

By: S. L. Berger (Editor), O. Nakanishi (Editor), B. Haendler (Editor)

Hardcover | 22 February 2006

At a Glance

Hardcover


$169.00

or 4 interest-free payments of $42.25 with

 or 

Ships in 5 to 7 business days

Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.

More in Biochemistry

Pihkal : A Chemical Love Story : A Chemical Love Story - Alexander T. Shulgin
Proteomics : Techniques and Technology - Peter Wyatt
Principles of Protein Chemistry - Nigel Stokes
Plant Chemical Ecology - Nancy Flint

$447.75

Extracellular Matrix Biology - Brian Keathley
Nectaries and Nectar - Leyla Monique

$464.75

New Insights into Vitamin D - John Edwards
Tihkal : The Continuation - Alexander Shulgin

RRP $54.99

$43.75

20%
OFF
V is for Venom : Agatha Christie's Chemicals of Death - Kathryn Harkup
Linear Algebra: A Modern Introduction : 4th Edition - David Poole

RRP $189.95

$152.75

20%
OFF