| Contributors | p. xiii |
| Preface | p. xv |
| Previous Volumes in Series | p. xvii |
| Formation of the Aqueous Humor: Transport Components and Their Integration | |
| Overview | p. 2 |
| Introduction | p. 2 |
| Structure of Ciliary Epithelium | p. 6 |
| Unidirectional Secretion of Aqueous Humor | p. 6 |
| Potential Unidirectional Reabsorption of Aqueous Humor | p. 18 |
| Regulation of Net Aqueous Humor Secretion | p. 19 |
| Summary of Current Views, Recent Advances, and Future Directions | p. 30 |
| References | p. 33 |
| Ocular Aquaporins and Aqueous Humor Dynamics | |
| Overview | p. 47 |
| Introduction | p. 48 |
| Aquaporins: Discovery, Structure, and Function | p. 48 |
| Ocular Distribution of Aquaporins | p. 50 |
| Aquaporins and Aqueous Humor Dynamics | p. 54 |
| Ion Channel Activity of AQP1 | p. 60 |
| Aquaporin and Ion Channel Interactions | p. 61 |
| Future Directions | p. 64 |
| References | p. 65 |
| The Role of Gap Junction Channels in the Ciliary Body Secretory Epithelium | |
| Overview | p. 71 |
| Introduction | p. 72 |
| General Properties of Connexins Including Those Composing the Ciliary Body Epithelium Gap Junctions | p. 75 |
| Modeling of Fluid Transport by the Ciliary Epithelium | p. 79 |
| Animal Models Support a Role for Gap Junctions in Fluid Transport by Ocular Epithelia | p. 92 |
| References | p. 93 |
| Regional Dependence of Inflow: Lessons from Electron Probe X-ray Microanalysis | |
| Overview | p. 98 |
| Introduction | p. 98 |
| Review of Electron-probe X-ray Microanalysis | p. 99 |
| Total Inflow | p. 103 |
| Topography of Inflow | p. 110 |
| A New Model for Aqueous Humor Production | p. 114 |
| Effect of Timolol on Inflow | p. 117 |
| Future Directions | p. 119 |
| References | p. 119 |
| Functional Modulators Linking Inflow with Outflow of Aqueous Humor | |
| Overview | p. 123 |
| Introduction | p. 124 |
| Sources of Neuropeptides and Peptide Hormones in the AqH | p. 125 |
| Neuroendocrine Characteristics of the Bilayered CE | p. 128 |
| Neuroendocrine Phenotype of the TM | p. 137 |
| Regulation of Neuroendocrine Signals: The Potential Role of Neutral Endopeptidase 24.11 (Neprelysin) | p. 138 |
| Neuroendocrine Signaling in the CE and TM | p. 140 |
| Putative Glutamatergic System in the Inflow-Outflow Axis: Glutamate as a Functional Endocrine/Paracrine Signal Between CE and TM Cells | p. 141 |
| Implications of a Neuroendocrine Signaling in the Anterior Segment of the Eye | p. 145 |
| Summary | p. 150 |
| References | p. 151 |
| Aqueous Humor Outflow Resistance | |
| Overview | p. 161 |
| Introduction | p. 162 |
| The Aqueous Humor | p. 165 |
| Regions of Low Outflow Resistance | p. 165 |
| Regions of Potential Significant Outflow Resistance | p. 171 |
| Endothelial Lining of Schlemm's Canal | p. 178 |
| Summary | p. 186 |
| References | p. 186 |
| Aqueous Humor Dynamics I | |
| Overview | p. 193 |
| Components of Aqueous Humor Dynamics and Measurement Techniques | p. 194 |
| Aqueous Humor Dynamics in Research Animals | p. 218 |
| Summary | p. 222 |
| References | p. 222 |
| Aqueous Humor Dynamics II | |
| Overview | p. 232 |
| Introduction | p. 232 |
| Normal Values of Aqueous Humor Dynamics in Humans | p. 233 |
| Clinical Syndromes | p. 237 |
| Drugs Affecting Aqueous Humor Dynamics | p. 246 |
| Summary | p. 259 |
| References | p. 259 |
| Effects of Circulatory Events on Aqueous Humor Inflow and Intraocular Pressure | |
| Overview | p. 273 |
| Introduction | p. 274 |
| Iop Effects on Ocular Blood Flow | p. 274 |
| Ocular Blood Flow Effects on IOP | p. 275 |
| Ciliary Blood Flow and Aqueous Production | p. 281 |
| Episcleral Venous Pressure and IOP | p. 295 |
| Conclusion | p. 296 |
| References | p. 297 |
| Retinal Ganglion Cells and Glaucoma: Traditional Patterns and New Possibilities | |
| Overview | p. 301 |
| Introduction | p. 302 |
| Influences on Glaucomatous Damage to Ganglion Cells | p. 303 |
| Mechanisms of Ganglion Cell Death | p. 307 |
| Conclusion | p. 315 |
| References | p. 316 |
| What is Functional Genomics Teaching us about Intraocular Pressure Regulation and Glaucoma | |
| Overview | p. 324 |
| Introduction | p. 324 |
| Functional Genomics: Microarrays, Proteomics and Protein Modification | p. 326 |
| Tissues Involved in the Development of Glaucoma. Survey of Microarray Studies | p. 329 |
| The Trabecular Meshwork Tissue: Expressed Genes (CDNA) and Proteins Obtained by Direct Sequencing and Mass Spectrometry | p. 335 |
| The Trabecular Meshwork Tissue: In Search of Genes Responding to Glaucomatous Insults | p. 348 |
| Proposed Molecular Signature of Human Glaucoma | p. 361 |
| References | p. 365 |
| Molecular Approaches to Glaucoma: Intriguing Clues for Pathology | |
| Overview | p. 379 |
| Transforming Growth Factor-B | p. 380 |
| Thrombospondin-1 | p. 383 |
| Connective Tissue Growth Factor | p. 384 |
| Bone Morphogenetic Protein-7 | p. 388 |
| Myocilin | p. 389 |
| Optineurin | p. 403 |
| WD Repeat Domain 36 | p. 410 |
| Conclusion | p. 411 |
| References | p. 411 |
| Outflow Signaling Mechanisms and New Therapeutic Strategies for the Control of Intraocular Pressure | |
| Overview | p. 428 |
| Introduction | p. 428 |
| New Approaches for IOP Lowering | p. 439 |
| Future Therapeutic Opportunities | p. 455 |
| References | p. 457 |
| Index | p. 471 |
| Table of Contents provided by Ingram. All Rights Reserved. |
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