Structure-Function Relationships of Human Pathogenic Viruses

By: Andreas Holzenberg, Elke Bogner, A. Holzenburg

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Hardcover | 30 April 2002

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552 Pages

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22.86 x 15.24 x 3.81

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Structure-Function Relationships of Human Pathogenic Viruses provides information on the mechanisms by which viruses enter the cell, replicate, package their DNA into capsids and mature into new virions. The relation between structural features and the pathogenicity and oncogenicity of some of the most relevant human viral pathogens are demonstrated and the acquisition of defense mechanisms through virus-host interactions are presented. In contrast to textbooks, this volume combines timely research data to provide a holistic view of viral pathogenesis.

Furthermore Structure-Function Relationships of Human Pathogenic Viruses illustrates in a single volume the fundamental processes involved in viral life cycles using up-to-date information from research laboratories around the world. Knowledge of these processes is crucial to develop rationales for the design of future drugs. The timeliness of the data and the comprehensive yet concise approach this book takes in order to present the world of viral pathogens should make it a frontrunner in higher education and R&D.

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Epstein Barr Virus Glycoproteins and Their Roles in Virus Entry and Egress	p. 3
Structure and Function of Viral Glycoproteins in Membrane Fusion	p. 25
Viral RNA-directed Polymerases: Structure and Function Relationships	p. 57
Marburg Virus Replication and Nucleocapsid Formation: Different Jobs, Same Players	p. 89
Packaging DNA into Herpesvirus Capsids	p. 111
From Concatemeric DNA into Unit-length Genomes - a Miracle or Clever Genes?	p. 155
Role of Envelope Proteins in Measles Virus Assembly	p. 173
The Predominant Varicella-zoster Virus gE and gI Glycoprotein Complex	p. 195
Expression Strategy and Function of the Filoviral Glycoproteins	p. 225
Prions: When Proteins Take a Wrong Turn	p. 255
Human Immunodeficiency Virus: From Virus Structure to Pathogenesis	p. 295
The Role of Hemagglutinin and Neuraminidase in Influenza Virus Pathogenesis	p. 331
Rhadinovirus Pathogenesis	p. 349
Interaction of Papillomaviral Oncoproteins with Cellular Factors	p. 431
Cytomegalovirus Glycoprotein Interacting with MHC Class I Molecules and MHC-encoded Peptide Transporter	p. 465
Regulation of Cellular Genes by Cytomegalovirus	p. 485
Index	p. 509
Table of Contents provided by Blackwell. All Rights Reserved.

Structure-Function Relationships of Human Pathogenic Viruses

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