Ernst Schering Foundation Symposium Proceedings

Kinases as Molecular Signaltransducers and Pharmacological Drug Targets in Inflammation

By: Gottfried Baier (Editor), Burkhart Schraven (Editor), Ulrich Zugel (Editor)

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Hardcover | 11 April 2008

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Hardcover
204 Pages

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20.96 x 14.61 x 1.52

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Protein phosphorylation is an essential post-translational modification that modulates cell-cell communication. Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation, migration, differentiation, and metabolism. The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity. Inhibitors that target protein kinases have proven efficacious in clinical settings and their continued development is the current focus of many drug discovery groups.

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Non-Fiction Science Biology, Life Sciences Biochemistry Medicine Other Branches of Medicine Pharmacology Pre-Clinical Medicine & Basic Sciences Life Sciences in General Genetics excluding Medical Clinical & Internal Medicine Diseases & Disorders

Immunology

Proteomics-Based Strategies in Kinase Drug Discovery	p. 1
PKC Isotype Functions in T Lymphocytes	p. 29
Systems Biology of T Cell Activation	p. 43
Solving the IRAK-4 Enigma: Application of Kinase-Dead Knock-In Mice	p. 63
Sensing, Presenting, and Regulating PAMPS	p. 83
Migration, Cell-Cell Interaction and Adhesion in the Immune System	p. 97
The Role of Diacylglycerol Kinases in T Cell Anergy	p. 139
Molecular Mechanisms that Control Leukocyte Extravasation Through Endothelial Cell Contacts	p. 151
Fragment-Based Drug Discovery Using Rational Design	p. 169
Table of Contents provided by Blackwell. All Rights Reserved.

Ernst Schering Foundation Symposium Proceedings

Kinases as Molecular Signaltransducers and Pharmacological Drug Targets in Inflammation

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

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