This book presents a unified set theory-based framework for spacecraft dynamics and control under multi-source uncertainties and data-sparse conditions. First, it develops reduced-order modeling techniques for high-dimensional spacecraft dynamics by introducing interval and convex set-based uncertainty descriptions, enabling efficient model reduction while rigorously quantifying unknown-but-bounded uncertainties without reliance on large-sample statistical assumptions. Second, the book addresses spacecraft attitude determination, attitude dynamics and control problems under uncertainty, establishing interval and convex set-based formulations for attitude dynamics and different control methods, including optimal control, sliding mode control, and periodic control, and systematically integrating non-probabilistic time-dependent reliability analysis into the dynamics and control design process to simultaneously account for performance and safety requirements. Finally, the proposed methodologies are extended to rigid-flexible coupling spacecraft, where attitude motion and structural vibration interact under uncertain conditions, and set theory-based spacecraft dynamics, optimal control and bounded model predictive control strategies are developed to achieve coordinated attitude-vibration suppression with guaranteed reliability and computational efficiency. Overall, the book provides a systematic methodology that links uncertainty dynamics, control synthesis, and reliability-based design optimization, offering both solid theoretical foundations and practical tools for the dynamics and control of advanced spacecraft operating in uncertain and data-limited environments.