Red Cell Development, 82

Volume 82

By: James Bieker

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Hardcover | 29 February 2008 | Edition Number 1

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227 Pages

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20.32 x 20.32 x 1.91

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1 Ontogeny of Erythropoiesis in the Mammalian Embryo
Kathle en McGrath and James Palis

2 The Erythroblast ic Island
Deepa Manwani and James J Bieker

3 Epigenetic Control of Complex Loci During Erythropoiesis
Ryan J. Wozniak and Emery H. Bresnick

4 The Role of the Epigenetic Signal, DNA Methylation, in Gene Regula tion During Erythroid Development
Gordon D. Ginder, Merlin N. Gnanapragasam, and Omar Y. Mian

5 Three-di mensional Organisation of Gene Expression in Erythroid Cells
Wouter de Laat, Petra Klous, Jurgen Kooren, Daan Noordermeer, Robert-J an Palstra, Marieke Simonis, Erik Splinter, Frank Grosveld

6. Iron Homeostasis and Erythropoiesis
Diedra M. Wrighting and Nancy C. Andrews

7. The Eff ects of Nitric Oxide on Red Cell Development and Phenotype
Vladan P. ?oki? and Alan N. Schechter

8. Diam ond Blackfan Anemia: A Disorder of Red Blood Cell Development<BR id='CRL

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Contributors	p. ix
Preface	p. xi
Ontogeny of Erythropoiesis in the Mammalian Embryo	p. 1
Introduction	p. 2
Primitive Erythropoiesis	p. 4
"Definitive" Erythropoiesis in the Fetus	p. 9
Developmental Origins of Erythropoiesis	p. 11
Conclusions	p. 14
Acknowledgments	p. 15
References	p. 15
The Erythroblastic Island	p. 23
Introduction	p. 24
Composition and Sites of Formation of Erythroblastic Islands	p. 26
Cell-Cell Adhesive Interactions Within Erythroblastic Islands	p. 35
Erythroblastic Island Functions	p. 39
Conclusion	p. 46
Acknowledgments	p. 46
References	p. 46
Epigenetic Control of Complex Loci During Erythropoiesis	p. 55
Introduction	p. 56
Utility of Analyzing Erythropoiesis to Dissect Epigenetic Mechanisms	p. 57
Epigenetic Control of the [beta]-like Globin Genes During Erythropoiesis	p. 58
Epigenetic Control of the Gataz Locus During Erythropoiesis	p. 69
Principles of Epigenetic Control Emerging from Studies of Erythropoiesis	p. 71
Acknowledgments	p. 73
References	p. 73
The Role of the Epigenetic Signal, DNA Methylation, in Gene Regulation During Erythroid Development	p. 85
Introduction	p. 86
DNA Methylation in Erythroid Cell Differentiation	p. 93
The [beta]-Globin Locus: A Model for the Role of DNA Methylation in Developmental Gene Regulation	p. 95
DNA Methylation of the Human [alpha]-Globin Locus	p. 104
DNA Methylation of Other Erythroid-Specific Genes	p. 106
Conclusions and Future Directions	p. 107
Acknowledgments	p. 108
References	p. 108
Three-Dimensional Organization of Gene Expression in Erythroid Cells	p. 117
Introduction: Three-Dimensional Studies in a Historical Context	p. 118
Long-Range Gene Activation and Gene Competition: DNA-Folding Matters?	p. 119
Novel Biochemical Approaches to Study DNA Topology: Insight into the Spatial Organization of the [beta]-Globin Locus	p. 123
The Functional Significance of Long-Range Interactions Between Regulatory Sequences	p. 125
Long-Range Contacts in Other Gene Loci	p. 127
Gene Positioning in the Nucleus: Spatial Coordination of Functionally Related Genes?	p. 129
Future Directions for Studies on Nuclear Architecture: 4C Technology	p. 132
References	p. 134
Iron Homeostasis and Erythropoiesis	p. 141
Introduction	p. 142
Iron Metabolism and Homeostasis	p. 142
Hepcidin	p. 147
Hepcidin and Erythropoeisis	p. 154
Conclusions	p. 158
References	p. 159
Effects of Nitric Oxide on Red Blood Cell Development and Phenotype	p. 169
Nitric Oxide	p. 170
NO Influence on Cell Differentiation	p. 180
NO Interaction with RBCs	p. 187
Effects of NO on Hemoglobin Expression	p. 192
Role of NO During Malaria Pathogenesis	p. 194
Effects of Fetal Hemoglobin Inducers on NO-cGMP Pathway	p. 195
Summary: NO and Erythropoiesis	p. 199
References	p. 200
Diamond Blackfan Anemia: A Disorder of Red Blood Cell Development	p. 217
Introduction	p. 218
Pathophysiology and Genetics: DBA, a Disorder of Ribosome Biosynthesis	p. 220
Other Diseases Linked to Defects in Ribosome Synthesis	p. 223
Ribosome Dysfunction and Red Blood Cell Development	p. 226
DBA Is a Cancer Predisposition Syndrome	p. 230
Treatment and Outcomes	p. 232
Summary	p. 235
References	p. 235
Index	p. 243
Contents of Previous Volumes	p. 249
Table of Contents provided by Ingram. All Rights Reserved.

Red Cell Development, 82

Volume 82

At a Glance

Hardcover

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How to return your order

Defective items

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